Results 71 to 80 of about 37,349 (239)

BPLF1 mitigates TBK1-induced dimerization of IRF3.

, 2023
IRF3 dimerization assay by native PAGE. BPLF1 and mutant C61A were transiently overexpressed in HEK293 cells together with TBK1 and V5-IRF3. Cells were harvested 48 hours after transfection.
Aradhana Bharti (14660028), Michael G. Botelho (14660034), Wai-Yin Lui (14660025), Dong-Yan Jin (8897), Kit-San Yuen (14660037), Sonia Jangra (11933249), Nok-Hei Mickey Wong (14660031)   +6 more
core   +1 more source

IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis

Advanced Science, EarlyView.
The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui, Yuening Sun, Ziyang Liu, Xuntao Lai, Yunshu Zhao, Yan'er Wang, Yuanming He, Fang Xu, Du Feng, Longlong Liu, Zhenqian Huang, Lijie Xing, Xinliang Mao   +12 more
wiley   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Pivotal role for the ESCRT-II complex subunit EAP30/SNF8 in IRF3-dependent innate antiviral defense.

PLoS Pathogens, 2017
The activation of interferon (IFN)-regulatory factor-3 (IRF3), characterized by phosphorylation and nuclear translocation of the latent transcription factor, is central to initiating innate antiviral responses.
Kattareeya Kumthip, Darong Yang, Nan L Li, Yunzhi Zhang, Meiyun Fan, Aarti Sethuraman, Kui Li   +6 more
doaj   +1 more source

Host innate immune response to influenza A virus infection : role of LGP2 and importance of NS1:CPSF30 interaction for virulence [PDF]

, 2013
textInfluenza A viruses can cause a highly contagious respiratory illness in humans. Immediately after virus infection the innate immune response is initiated by binding of viral RNA species to RIG-I that leads to activation of IRF3 and NF-κB ...
Malur, Meghana
core  

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

IRF3 is activated by EV71-derived RNA.

, 2013
(A) HeLa cells were transfected with 2 µg of poly(I:C), cellular total RNA of HeLa cells, or total RNA from EV71-infected HeLa cells for 20 h. The activation of IRF3 was analyzed by immunoblotting using anti-phospho-IRF3, anti-MDA5, anti-RIG-I, and anti ...
Shin-Ru Shih (110819), Sue-Jane Lin (409066), Rei-Lin Kuo (409064), Li-Ting Kao (409065), Robert Yung-Liang Wang (409067)   +4 more
core   +1 more source

NOG1 did not affect the interaction between IRF3 and CBP.

, 2023
(A) THP1 cells transfected with 150 nM of NOG1 or NC siRNA were immunoprecipitated with anti-IRF3 antibody. The impact of NOG1 on IRF3 binding onto IFN-β promoter was analyzed by quantitative ChIP assay.
Weijun Cao (122575), Haixue Zheng (286790), Zixiang Zhu (280085), Fan Yang (1413), Huisheng Liu (408091), Xiangtao Liu (286800), Qiao Xue (431091), Zhaoning Xue (14564656)   +7 more
core   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation [PDF]

, 2016
Cytosolic RNA/DNA sensing elicits primary defense against viral pathogens. Interferon regulatory factor 3 (IRF3), a key signal mediator/transcriptional factor of the antiviral-sensing pathway, is indispensible for interferon production and antiviral ...
Zhou, Yao, Feng, Xin-Hua, Wu, Shiying, Zou, Jian, Zhang, Qian, Xia, Zongping, Jin, Qiuheng, Plouffe, Steven W, Liu, Shengduo, Meng, Fansen, Zhou, Ruyuan, Song, Hai, Ye, Sheng, Guan, Kun-Liang, Zhao, Bin, Xu, Pinglong   +15 more
core   +1 more source