Results 91 to 100 of about 37,349 (239)

Targeting IRF3 as a YAP agonist therapy against gastric cancer

, 2018
The Hippo pathway plays a vital role in tissue homeostasis and tumorigenesis. The transcription factor IRF3 is essential for innate antiviral immunity. In this study, we discovered IRF3 as an agonist of Yes-associated protein (YAP).
Zhaocai Zhou, Shi Jiao, Jingmin Guan, Wenjia Wang, Yunfeng Cheng, Min Chen, Yugong Wang, Chuanchuan Li   +7 more
core   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Interferon Regulatory Factor 3 Exacerbates the Severity of COVID-19 in Mice

Critical Care Explorations
CONTEXT:. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019, causing the COVID-19 pandemic. While most infected people experienced mild illness, others progressed to severe disease, characterized by hyperinflammation and ...
Wendy E. Walker, PhD, Luiz F. Garcia, MS, Pedro M. Palermo, PhD, Nawar Hakim, MD, Dinesh G. Goswami, PhD, Alok K. Dwivedi, PhD, Douglas M. Watts, PhD   +6 more
doaj   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Zebrafish mylipb attenuates antiviral innate immunity through two synergistic mechanisms targeting transcription factor irf3.

PLoS Pathogens
IFN regulatory factor 3 (IRF3) is the transcription factor crucial for the production of type I IFN in viral defence and inflammatory responses. The activity of IRF3 is strictly modulated by post-translational modifications (PTMs) to effectively protect ...
Zhi Li, Jun Li, Ziyi Li, Yanan Song, Yanyi Wang, Chunling Wang, Le Yuan, Wuhan Xiao, Jing Wang   +8 more
doaj   +1 more source

Effects of IRF3 siRNA on inflammatory cytokines gene expression.

, 2015
BEAS-2B cells were transfected with IRF3 siRNA (solid bars) or a random oligomer negative control (shadowed bars). After 24 hours of transfection, the siRNA transfection mix was replaced with a fresh LHC-9 medium.
Noriyuki Enomoto (322372), Tomoyuki Fujisawa (552309), Yutaro Nakamura (552307), Kazutaka Mori (254785), Katsumasa Yamanaka (801517), Masato Maekawa (552311), Takafumi Suda (509192), Hideki Kusagaya (801516), Dai Hashimoto (552308), Naoki Inui (552310)   +9 more
core   +1 more source

Phosphorylation of IRF3 at Y107 mediated by BLK is essential for virus-triggered innate antiviral response.

, 2023
(A) Effects of BLK and BLK(K269A) on SeV- or EMCV-induced transcription of downstream antiviral genes. U87MG cells (2 × 105) were transfected with BLK or BLK(K269A) plasmids for 24 h.
Ji-Yan Zhang (551912), Hai-Xue Zheng (544167), Zi-Xiang Zhu (17271371), Yi-Zhuo Wang (9724460), Xu-Xu Fan (17271368), Yan-Yi Wang (3930020), Dan-Shi Pei (17271380), Wei-Wei Li (276638), Xue-Jing Cao (17271374), Zhao-Yu Zhu (17271377)   +9 more
core   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source