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Chicken viperin inhibits fowl adenovirus serotype 4 replication and affects related innate immune signaling pathways. [PDF]
Poult SciWan L +12 more
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IRF7: Activation, Regulation, Modification and Function [PDF]
Genes and Immunity, 2011 Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I interferons (IFNs) against pathogenic infections, which activate IRF7 by triggering signaling cascades from pathogen recognition receptors (PRRs) that recognize pathogenic nucleic
Shunbin Ning, Glen N. Barber, J S Pagano
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Protein Phosphatase 1 Abrogates IRF7-Mediated Type I IFN Response in Antiviral Immunity [PDF]
European Journal of Immunology, 2016 Interferon (IFN) regulatory factor 7 (IRF7) plays a key role in the production of IFN‐α in response to viral infection, and phosphorylation at IRF7 C‐terminal serine sites is prelude to its function.
Shunbin Ning, Ling Wang, Juan Zhao
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Virology, 2018 Seneca Valley Virus (SVV) is a newly emerged virus belonging to the family Picornaviridae. Basic knowledge of the immunological response to SVV is limited. To date, one study has demonstrated that SVV 3Cpro mediates the cleavage of host MAVS, TRIF, and TANK at specific sites and consequently escapes the host's antiviral innate immunity.
Haixue Zheng, Zixiang Zhu, Huisheng Liu
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TARBP2 Inhibits IRF7 Activation by Suppressing TRAF6-Mediated K63-Linked Ubiquitination of IRF7
Molecular Immunology, 2019Interferon regulatory factor 7 (IRF7), a crucial regulator of type I interferons (IFNs), plays a crucial role in resistance to viral infection. The abnormal production of type I IFNs is associated with many types of disease, such as cancer and inflammatory disorders.
Changqing, Liangguo Xu, Weiying Wang
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ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7
Circulation Research, 2022Background: ADAR1 (adenosine deaminase acting on RNA-1)-mediated adenosine to inosine (A-to-I) RNA editing plays an essential role for distinguishing endogenous from exogenous RNAs, preventing autoinflammatory ADAR1 also regulates cellular processes by recoding specific mRNAs, thereby altering protein functions, but may also ...
Claudia Garcia-Gonzalez +11 more
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