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Functional characterization of an IRF7 homologue in large yellow croaker (Larimichthys crocea)
Fish & Shellfish ImmunologyInterferon regulatory factor 7 (IRF7) functions as a central orchestrator of type I interferon (IFN) responses in mammals, yet the functional mechanisms of its homologue in teleost remains incompletely understood. Here, we characterized an IRF7 homologue (LcIRF7) in large yellow croaker (Larimichthys crocea).
Wenxing Li +4 more
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MEKK3 Activates IRF7 to Trigger a Potent Type I Interferon Induction in Response to TLR7/9 Signaling
Molecular Immunology, 2021Ao Chen, Xiang Zhou, Miaomiao Cai
exaly
Expression of IRG1 in Microglia and its Effects on Hif1α and IRF7
Upon exposure to LPS and IFNγ, IRG1 (immune-responsive gene 1) expression highly increases in macrophages and microglia. It regulates immunometabolism in the cell and so is involved in metabolic and inflammatory changes cells go through under inflammatory conditions. Some of the major transcription factors that regulate cell metabolism and inflammatoryRubavičiūtė, Estera +1 more
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BUD13 Promotes a Type I Interferon Response by Countering Intron Retention in Irf7
Molecular Cell, 2019David Baltimore +2 more
exaly