Results 201 to 210 of about 24,207 (226)

IRF7 Promotes Glioma Cell Invasion by Inhibiting AGO2 Expression

Tumor Biology, 2015
Interferon regulatory factor 7 (IRF7) is the master transcription factor that plays a pivotal role in the transcriptional activation of type I interferon genes in the inflammatory response. Our previous study revealed that IRF7 is an important regulator of tumor progression via the expression of inflammatory cytokines in glioma.
Xiong Jin, Hyunggee Kim, Seon Yong Lee
exaly   +3 more sources

Knockout of IRF7 Highlights Its Modulator Function of Host Response Against Avian Influenza Virus and the Involvement of MAPK and TOR Signaling Pathways in Chicken [PDF]

Genes, 2020
Interferon regulatory factor 7 (IRF7) is known as the master transcription factor of the type I interferon response in mammalian species along with IRF3.
Huaijun Zhou, Colin Kern, Tae Hyun Kim
exaly   +2 more sources

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IRF7, a functional factor associates with systemic lupus erythematosus

Cytokine, 2012
Systemic lupus erythematosus is an autoimmune disease attributing to a combination of genetic and environmental factors. Abnormal expression/function of type I interferons has been demonstrated with the pathogenesis of SLE, especially IFN-α, which can be regulated by IFN regulatory factor 7 (IRF7).
Wang-Dong, Xu, Yu-Jing, Zhang, Ke, Xu, Yu, Zhai, Bao-Zhu, Li, Hai-Feng, Pan, Dong-Qing, Ye   +6 more
openaire   +2 more sources

IRF7 suppresses hematopoietic regeneration under stress via CXCR4

Stem Cells, 2020
Abstract Hematopoietic stem cells (HSCs) maintain quiescence under steady state; however, they are compelled to proliferate and expand to replenish the blood system under stress. The molecular basis underlying stress hematopoiesis remains to be fully understood.
Ying-Ying Chen, Yu-Feng Liu, Yong-Dong Liu, Xiao-Hui Deng, Jie Zhou   +4 more
openaire   +2 more sources

Functions of the Two Zebrafish MAVS Variants Are Opposite in the Induction of IFN1 by Targeting IRF7

Fish and Shellfish Immunology, 2015
IFNs create the first line of host cells to defense viral infection, however, unrestricted expression of IFN can be hazardous to the host. IRF7 is the master regulator of type I IFN expression.
Shun Li, Yong-An Zhang, Long-Feng Lü
exaly   +2 more sources

Insight into the role of IRF7 in skin and connective tissue diseases

Experimental Dermatology
AbstractInterferons (IFNs) are signalling proteins primarily involved in initiating innate immune responses against pathogens and promoting the maturation of immune cells. Interferon Regulatory Factor 7 (IRF7) plays a pivotal role in the IFNs signalling pathway.
Lian Wang, Fengjuan Yang, Jing Ye, Lu Zhang, Xian Jiang   +4 more
openaire   +2 more sources

Non-Transcriptional IRF7 Interacts With NF-κB to Inhibit Viral Inflammation

Journal of Biological Chemistry
Interferon (IFN) regulatory factors (IRF) are key transcription factors in cellular antiviral responses. IRF7, a virus-inducible IRF, expressed primarily in myeloid cells, is required for transcriptional induction of interferon α and antiviral genes. IRF7 is activated by virus-induced phosphorylation in the cytoplasm, leading to its translocation to ...
Sonam Popli, Saurabh Chattopadhyay, Ritu Chakravarti   +2 more
exaly   +3 more sources

SGIV VP82 inhibits the interferon response by degradation of IRF3 and IRF7

Fish & Shellfish Immunology
During virus-host co-evolution, viruses have developed multiple strategies to dampen IFN response and prevent its antiviral activity in host cells. To date, the interactions between host IFN response and the immune evasion strategies exploited by fish iridoviruses still remain largely uncertain.
Yu, Wang, Shanxing, Liu, Wenji, Wang, Lin, Liu, Yin, Zhao, Qiwei, Qin, Xiaohong, Huang, Youhua, Huang   +7 more
openaire   +2 more sources

Evolutionary and functional conservation of IRF7 in the Tibetan frog Nanorana parkeri

Molecular Biology Reports
The production of interferons (IFNs) is essential for the control of viral infections, and interferon regulatory factor 7 (IRF7) is considered as a vital regulator for the transcription of type I IFNs. Amphibians appear to possess a highly expanded type I IFN repertoire, consisting of intron-containing genes as observed in fish, and intronless genes as
Qing Wang, Bo Li, Xin Na Sun, Zhen Gan
openaire   +2 more sources

IRF7 in peripheral monocytes drives BBB disruption in anti-NMDAR encephalitis

Brain, Behavior, and Immunity
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe neurological disorder characterized by the presence of autoantibodies against the NMDAR and blood-brain barrier (BBB) disruption. This study investigates the involvement of monocytes and interferon regulatory factor 7 (IRF7) in BBB leakage of this disease.
Qihui Li, Li Xiao, Jianfang Li, Yu Huang, Shishi Shen, Huilu Li, Fuhua Peng, Huichang He, Shen Huang, Jian Sun, Wei Qiu, Wei Cai, Yaqing Shu   +12 more
openaire   +2 more sources