Results 31 to 40 of about 6,410 (167)

Establishing the Role of Iridoids as Potential Kirsten Rat Sarcoma Viral Oncogene Homolog G12C Inhibitors Using Molecular Docking; Molecular Docking Simulation; Molecular Mechanics Poisson–Boltzmann Surface Area; Frontier Molecular Orbital Theory; Molecular Electrostatic Potential; and Absorption, Distribution, Metabolism, Excretion, and Toxicity Analysis

Molecules, 2023
The RAS gene family is one of the most frequently mutated oncogenes in human cancers. In KRAS, mutations of G12D and G12C are common. Here, 52 iridoids were selected and docked against 8AFB (KRAS G12C receptor) using Sotorasib as the standard. As per the
Mubarak A. Alamri, Abdullah S. Alawam, Mohammed Merae Alshahrani, Sarkar M. A. Kawsar, Prinsa, Supriyo Saha   +5 more
doaj   +1 more source

Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome

Cellular Physiology and Biochemistry, 2017
Background/Aims: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women, and it is usually characterized by chronic inflammation, oxidative stress, and altered microRNA expression. The aim of this study is to investigate how the effects
Tao Zuo, Minghui Zhu, Wenming Xu, Zhixia Wang, Hang Song   +4 more
doaj   +1 more source

The genus Vitex: An overview of iridoids as chemotaxonomic marker

Beni-Suef University Journal of Basic and Applied Sciences, 2018
In our continuing work on Vitex genus, the phytochemical investigation of leaves of Vitex grandifolia led to the isolation of two iridoids known in the literature as agnuside and bartsioside.
M. Oluwasesan Bello, Ahmed A. Zaki, Sinmisola Aloko, Pius S. Fasinu, E. Oluwatoyin Bello, Usman L. Ajao, Olubunmi S. Oguntoye   +6 more
doaj   +1 more source

Synthesis of Non-natural Aza-Iridoids via Ynamides and Molecular Networking-Based Tracing of Their In Planta Bioconversion

, 2022
A synthesis of new-to-nature aza-iridoids via ynamides is presented. ZrCl4 proved to be the best acid to perform this transformation. Various ynamides were accommodated, and seco-iridoids could be obtained as well.
Clément Gommenginger (12536064), Nicolas Navrot (5465141), David Elser (12536070), Baptiste Moegle (12536061), Laurence Miesch (4448011), Emmanuel Gaquerel (200665), Asmaa Belabbes (12536067), Claire Villette (555604), Maxime Hourtoule (12308149)   +8 more
core   +1 more source

The occurrence of iridoids in plants

Acta Societatis Botanicorum Poloniae, 2014
The occurrence of iridoids (iridoid glucosides, secoiridoids, valtrates, iridoids Plumeria) in the taxa of plants and their taxonomic significance are refered.
Emilia Andrzejewska-Golec
doaj   +1 more source

Iridoids in Hydrangeaceae [PDF]

, 2016
The content of glycosides in Kirengeshoma palmata and Jamesia americana (Hydrangeaceae) have been investigated. The former contains loganin and secoiridoids, including the alkaloid demethylalangiside.
Gousiadou, Chryssoula, Gotfredsen, Charlotte Held, Jensen, Søren Rosendal, Li, Hong-Qing   +3 more
core   +1 more source

Iridoids and seco‐iridoids from the leaves of Cephalanthus glabratus (Spreng.) K.Schum

, 2020
In this work, the first phytochemical analysis on Cephalanthus glabratus (Spreng.) K.Schum. regarding its composition in iridoids was reported. The analysis was carried out by following current usual methodologies in the extraction, separation and ...
Lamberto Tomassini, Sebastiano Foddai, Claudio Frezza, Antonio Ventrone, Mauro Serafini   +4 more
core   +1 more source

Iridoids and bis-iridoids from Patrinia scabiosaefolia

, 2017
Ten new iridoids, patriscabioins A–J (1–10), and three unique bis-iridoids, patriscabiobisins A–C (11–13), together with seven known analogues, have been identified from whole plants of Patrinia scabiosaefolia.
Bo Hou, Liu Yang, Jun Zhou, Jin-Yu Li, Jiang-Miao Hu, Zhen-Hua Liu, Rui-Jing Ma   +6 more
core   +1 more source

Iridoid terpenoids: a class of promising compounds to regulate blood glucose

Food & Medicine Homology
Iridoids derived from plants have demonstrated promising effects in regulating glycemic levels, which have captured the attention of researchers. Thus, an overview of iridoids with hypoglycemic activity, with a particular focus on their potential ...
Wen-Jing Guo, Yu Zhang, Hassan Elsayed, Chang-Qin Li, Xiao-Yu Chen   +4 more
doaj   +1 more source

IRIDOIDS FROM MENTZELIA-CORDIFOLIA

, 1995
From the aerial parts of Mentzelia cordifolia, 11 known compounds, seven phenolics and four iridoids have been identified. In addition, two new iridoids, i.e, mentzefoliol and glucosylmentzefoliol, have been isolated and characterized.
Anna Rita Bilia, MORELLI, IVANO, NICOLETTI M., CATALANO, SERENA, Guido Flamini, Serena Catalano, NICOLETTI, Marcello, BILIA A. R., FLAMINI, GUIDO, Ivano Morelli   +9 more
core   +1 more source