Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway [PDF]
Communications Biology, 2023 Iron-sulfur clusters are essential for life and defects in their biosynthesis lead to human diseases. The mechanism of cluster assembly and delivery to cytosolic and nuclear client proteins via the cytosolic iron-sulfur cluster assembly (CIA) pathway is ...
Sheena Vasquez +7 more
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Crystallographic characterization of the high-potential iron-sulfur protein in the oxidized state at 0.8 Å resolution. [PDF]
PLoS ONE, 2017 High-potential iron-sulfur protein (HiPIP) is a soluble electron carrier protein of photosynthetic bacteria with an Fe4S4 cluster. Although structural changes accompanying the electron transfer are important for understanding of the functional mechanism,
Hiraku Ohno +6 more
doaj +1 more source
Sulfur Administration in Fe–S Cluster Homeostasis
Antioxidants, 2021 Mitochondria are the key organelles of Fe–S cluster synthesis. They contain the enzyme cysteine desulfurase, a scaffold protein, iron and electron donors, and specific chaperons all required for the formation of Fe–S clusters.
Leszek Rydz +2 more
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Biophysical Characterization of Iron-Sulfur Proteins
Bio-Protocol, 2021 Iron-sulfur proteins are primordial catalysts and biological electron carriers that today drive major metabolic pathways across all forms of life. They can access a diversity of oxidation states and can mediate electron transfer over an extended range of
Bhanu Jagilinki +4 more
doaj +1 more source
Iron–Sulfur Cluster Biogenesis and Iron Homeostasis in Cyanobacteria
Frontiers in Microbiology, 2020 Iron–sulfur (Fe–S) clusters are ancient and ubiquitous cofactors and are involved in many important biological processes. Unlike the non-photosynthetic bacteria, cyanobacteria have developed the sulfur utilization factor (SUF) mechanism as their main ...
Fudan Gao
doaj +1 more source
UV-light-driven prebiotic synthesis of iron–sulfur clusters [PDF]
, 2017 Iron–sulfur clusters are ancient cofactors that play a fundamental role in metabolism and may have impacted the prebiotic chemistry that led to life.
Bonfio, Claudia +13 more
core +1 more source
Interaction of the Streptomyces Wbl protein WhiD with the principal sigma factor σHrdB depends on the WhiD [4Fe-4S] cluster [PDF]
, 2020 The bacterial protein WhiD belongs to the Wbl family of iron–sulfur [Fe-S] proteins present only in the actinomycetes. In Streptomyces coelicolor, it is required for the late stages of sporulation, but precisely how it functions is unknown.
Bush, Matthew +4 more
core +1 more source
Frontiers in Neuroscience, 2022 Friedreich’s ataxia (FRDA) is the most prevalent autosomic recessive ataxia and is associated with a severe cardiac hypertrophy and less frequently diabetes.
Beata Monfort +3 more
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Iron–sulfur clusters: from metals through mitochondria biogenesis to disease [PDF]
, 2018 Iron–sulfur clusters are ubiquitous inorganic co-factors that contribute to a wide range of cell pathways including the maintenance of DNA integrity, regulation of gene expression and protein translation, energy production, and antiviral response ...
Cardenas-Rodriguez, Mauricio +2 more
core +1 more source
Description of peptide bond planarity from high-resolution neutron crystallography
Biophysics and Physicobiology, 2023 Neutron crystallography is a highly effective method for visualizing hydrogen atoms in proteins. In our recent study, we successfully determined the high-resolution (1.2 Å) neutron structure of high-potential iron-sulfur protein, refining the coordinates
Yuya Hanazono +3 more
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