Results 21 to 30 of about 81,735 (304)
Down the Iron Path: Mitochondrial Iron Homeostasis and Beyond
Cells, 2021 Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent. Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate these cofactors along with iron ions into mitochondrial proteins that support ...
Jonathan V. Dietz +2 more
doaj +1 more source
Clinical and genetic aspects of defects in the mitochondrial iron-sulfur cluster synthesis pathway [PDF]
, 2018 Iron-sulfur clusters are evolutionarily conserved biological structures which play an important role as cofactor for multiple enzymes in eukaryotic cells.
Van Coster, Rudy, Vanlander, Arnaud
core +2 more sources
Cluster and fold stability of E. coli ISC-type ferredoxin.
PLoS ONE, 2013 Iron-sulfur clusters are essential protein prosthetic groups that provide their redox potential to several different metabolic pathways. Formation of iron-sulfur clusters is assisted by a specialised machine that comprises, among other proteins, a ...
Robert Yan +6 more
doaj +1 more source
Crystallographic snapshots of sulfur insertion by lipoyl synthase [PDF]
, 2018 Lipoyl synthase (LipA) catalyzes the insertion of two sulfur atoms at the unactivated C6 and C8 positions of a protein-bound octanoyl chain to produce the lipoyl cofactor. To activate its substrate for sulfur insertion, LipA uses a [4Fe-4S] cluster and S-
Booker, Squire J. +5 more
core +1 more source
Insights from 125Te and 57Fe nuclear resonance vibrational spectroscopy: a [4Fe-4Te] cluster from two points of view. [PDF]
, 2019 Iron-sulfur clusters are common building blocks for electron transport and active sites of metalloproteins. Their comprehensive investigation is crucial for understanding these enzymes, which play important roles in modern biomimetic catalysis and ...
Apfel, Ulf-Peter +8 more
core +2 more sources
Spectral decomposition of iron-sulfur clusters
Analytical Biochemistry, 2021 The near universal availability of UV-Visible spectrophotometers makes this instrument a highly exploited tool for the inexpensive, rapid examination of iron-sulfur clusters. Yet, the analysis of iron-sulfur cluster reconstitution experiments by UV-Vis spectroscopy is notoriously difficult due to the presence of broad, ill-defined peaks. Other types of
Isaiah O. Betinol +2 more
openaire +3 more sources
Structural Basis of RICs Iron Donation for Iron-Sulfur Cluster Biogenesis
Frontiers in Microbiology, 2021 Escherichia coli YtfE is a di-iron protein of the widespread Repair of Iron Centers proteins (RIC) family that has the capacity to donate iron, which is a crucial component of the biogenesis of the ubiquitous family of iron-sulfur proteins.
Liliana S. O. Silva +4 more
doaj +1 more source
Biomolecules, 2021 Maintaining iron homeostasis is fundamental for almost all living beings, and its deregulation correlates with severe and debilitating pathologies.
Cécilia Hognon +5 more
doaj +1 more source
Sensing iron availability via the fragile [4Fe-4S] cluster of the bacterial transcriptional repressor RirA [PDF]
, 2017 Rhizobial iron regulator A (RirA) is a global regulator of iron homeostasis in many nitrogen-fixing Rhizobia and related species of α-proteobacteria.
Agar +67 more
core +1 more source
Lights on Iron-Sulfur Clusters
Chemistry & Biology, 2009 The biogenesis of iron-sulfur proteins within a living cell is traditionally investigated by enzyme activity measurements and radiolabeling techniques. In this issue of Chemistry and Biology, Hoff et al. introduce a non-invasive fluorescence-based method to trace the formation of iron-sulfur clusters at high sensitivity.
Lillig, C., Lill, R.
openaire +3 more sources