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Iron Chelating Agents for the Treatment of Iron Overload
Coordination Chemistry Reviews, 2008The importance of iron chelators in medicine has significantly increased in recent years. Iron is essential for life but it is also potentially more toxic than other trace elements. This is because we lack effective means to protect human cells against iron overload and because of the role of iron in the generation of free radicals. In order to protect
Guido Crisponi, Maurizio Remelli
exaly +2 more sources
Applied Microbiology and Biotechnology, 2012 International audienceThe introduction of various iron-chelating agents to the Magnetospirillum magneticum strain AMB-1 bacterial growth medium stimulated the growth of M.
Edouard Alphandéry +2 more
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Potential of Application of Iron Chelating Agents in Ophthalmic Diseases [PDF]
Seminars in Ophthalmology, 2021 The investigations discussed in this review indicate that iron may exacerbate different eye diseases. Therefore, it is plausible that reducing cellular or body iron stores could influence disease pathogenesis, so it is logical to consider the iron chelators' potential protective role in the various ophthalmic diseases in the form of topical eye drops ...
Joseph B Ciolino
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Silybin, a new iron-chelating agent
Journal of Inorganic Biochemistry, 2001Silybin, a natural occurring flavolignan isolated from the fruits of Silibum marianum, has been reported to exert antioxidant and free radical scavenging abilities. It was suggested to act also as an iron chelator. The complexation and protonation equilibria of the ferric complex of this compound have been studied by potentiometric, spectrophotometric ...
BORSARI, Marco +6 more
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A Rapid Assay for Evaluation of Iron-Chelating Agents in Rats [PDF]
Blood, 1981 Abstract The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hepatocytes ...
Ca Finch, M J Pippard
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Iron-Chelating Agents in Non-Iron Overload Conditions
Annals of Internal Medicine, 1994To review the current clinical experience with iron chelators in non-iron overload conditions.The English-language literature was searched from 1983 through 1992 manually and using MEDLINE.Original articles, case reports, and abstracts addressing iron chelation.Selected reports that described clinical applications of iron chelators in non-iron overload
E E, Voest, G, Vreugdenhil, J J, Marx
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Iron mobilization from ferritin by chelating agents
Journal of Inorganic Biochemistry, 1980The release of iron from horse spleen ferritin by the chelating agents desferrioxamine B, rhodotorulic acid, 2,3-dihydroxybenzoate, 2,2'-bipyridyl and pyridine-2-aldehyde-2-pyridyl hydrazone (Paphy) has been studied in vitro. Ferritin prepared by classical procedures involving thermal denaturation releases its iron less effectively than ferritin ...
Crichton, Robert +2 more
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Iron chelators as therapeutic iron depletion agents
Expert Opinion on Therapeutic Patents, 2006The great promise of iron depletion as a therapeutic strategy for various diseases, including iron overload, cancers, Alzheimer’s disease, Parkinson’s disease, tuberculosis, HIV, and fungal and malaria infection, has stimulated research on the development of iron chelators as iron depletion agents.
Noah Birch, Xiang Wang, Hyun-Soon Chong
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