Results 251 to 260 of about 2,116,690 (282)
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Iron chelators as therapeutic agents for the treatment of cancer
Critical Reviews in Oncology/Hematology, 2002A wide variety of studies in vitro, in vivo, and in clinical trials have demonstrated that the chelator currently used to treat iron overload disease, desferrioxamine, has anti-proliferative effects against both leukemia and neuroblastoma. However, the efficacy of desferrioxamine is severely limited due to its poor ability to permeate cell membranes ...
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Potential of iron chelators as effective antiproliferative agents
Canadian Journal of Physiology and Pharmacology, 1997Initially the impetus to develop iron (Fe) chelators for clinical use was based upon the need for a drug to treat Fe-overload diseases such as beta-thalassemia. However, it has become clear that Fe chelators may be useful for the treatment of a wide variety of disease states, including cancer, malaria, and free radical mediated injury.
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Determination of Iron Chelating Agents by Analytical Methods: A Review
Critical Reviews in Analytical Chemistry, 2019Acute iron poisoning and chronic iron overload consequences in significant morbidity and mortality worldwide. Treatment of acute iron poisoning and chronic iron overload can be challenging and care providers are often tackled with management dilemmas. Iron chelating agents are commonly prescribed for patients with iron deficiency anemia. In this review
Aamir, Malik +4 more
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Effect of iron-chelating agents on inhibitors of ribonucleotide reductase
Biochemical Pharmacology, 1981Abstract Ribonucleotide reductase from Ehrlich tumor cells is inhibited by hydroxyurea (HU), guanazole (GZ), pyrazolo-imidazole (IMPY), 1-formylisoquinoline thiosemicarbazone (IQ), 4-methyl-5-aminoisoquinoline thiosemicarbazone (MAIQ). and the dialdehydes of inosine and 5′-deoxyinosine.
J G, Cory, L, Lasater, A, Sato
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Inhibition of bacteria by lactoferrin and other iron-chelating agents
Biochimica et Biophysica Acta (BBA) - General Subjects, 1968When not fully saturated with iron, bovine, human and goat lactoferrins were bacteriostatic for Bacillus stearothermophilus and Bacillus subtilis in both the presence and absence of trace amounts of metals. Bovine lactoferrin inhibited the germination of spores and the growth of vegetative cells of B. stearothermophilus.
J D, Oram, B, Reiter
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Glycosyl‐Curcuminoids as Potential New Chelating Agents in Iron Overload Chelation Therapy
European Journal of Inorganic Chemistry, 2004AbstractThe iron(III) chelating ability of some glycosyl derivatives of curcuminoids is tested by means of UV, potentiometric and NMR studies. The pKa of the ligands and the stability constants of their Fe3+ and Ga3+ complexes are evaluated by UV spectroscopy. The only metal binding site of the ligand is the β‐dioxo moiety; the glycosyl moiety does not
B. Arezzini +5 more
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British Journal of Haematology, 1982
Fifteen compounds with a high affinity to ferric iron have been screened for in vivo iron-chelating efficiency in a rat model. One of the most potent of these drugs was ethylenediamine-N,N'-bis(o-hydroxyphenylglycine) (EHPG). EHPG-induced iron excretion was up to 8 times higher than iron excretion induced by identical doses of desferrioxamine (DF ...
C, Hershko, R W, Grady, G, Link
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Fifteen compounds with a high affinity to ferric iron have been screened for in vivo iron-chelating efficiency in a rat model. One of the most potent of these drugs was ethylenediamine-N,N'-bis(o-hydroxyphenylglycine) (EHPG). EHPG-induced iron excretion was up to 8 times higher than iron excretion induced by identical doses of desferrioxamine (DF ...
C, Hershko, R W, Grady, G, Link
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Combined Use of Reducing Agents and Biodegradable Chelating Agent for Iron Rust Removal
Journal of Oleo Science, 2022Masaru Oya
exaly
Determination of Iron Chelating Agents by Analytical Methods: A Review
Critical Reviews in Analytical Chemistry, 2020Sandip D Firke +2 more
exaly