Results 241 to 250 of about 2,116,690 (282)

The Effect of Chelating Agents on Cellular Iron Metabolism

Clinical Science, 1976
1. The effect of iron chelators on iron uptake, ferritin and total protein synthesis was studied in cultured Chang cells. Desferrioxamine depressed ferritin synthesis and completely inhibited iron uptake by ferritin protein. Rhodotorulic acid reduced iron uptake by the cells but had little effect on ferritin synthesis.
G P, White, R, Bailey-Wood, A, Jacobs
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Iron Chelating Agents in Clinical Practice

Coordination Chemistry Reviews, 1999
Abstract The relevance of iron chelators in medicine has increased in recent years. Iron is essential for life but it is also potentially more toxic than other trace elements. This is due to the lack of effective means to protect human cells against iron overload and to the role of iron in the generation of free radicals. To protect patients from the
Gavino Faa, Guido Crisponi
exaly   +3 more sources

Mobilization of ferritin iron in erythroblasts by chelating agents

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1985
Intracellular ferritin in newt (Triturus cristatus) erythroblasts was accessible to the chelating effects of EDTA and pyridoxal phosphate. EDTA (0.5-1 mM) promoted release of radioactive iron from ferritin of pulse-labelled erythroblasts during chase incubation, but its continuous presence was not necessary for ferritin iron mobilization.
J A, Grasso, T J, Hillis, J A, Mooney-Frank   +2 more
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EFFECT OF AN IRON‐CHELATING AGENT ON LYMPHOCYTE PROLIFERATION

Australian Journal of Experimental Biology and Medical Science, 1984
SummaryThe effect of the iron‐chelating: agent desferrioxamine on lymphocyte proliferation has been studied. Desferrioxamine at concentrations of 15 μM totally inhibited the proliferation of Concanavalin A‐stimulated lymphocytes, whereas iron‐saturated desferrioxamine was ineffective.
N, Bowern, I A, Ramshaw, P, Badenoch-Jones, P C, Doherty   +3 more
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Chelating Agents for the Treatment of Systemic Iron Overload

Current Medicinal Chemistry, 2012
The first successful therapeutic iron chelator was desferrioxamine which was introduced in the late 1960's by Ciba (now Novartis). Desferrioxamine has been an extremely successful compound having received the MMW "Pharmaceutical of the year" award for 1991. It is a life saving and a life - prolonging drug which improves the quality of life.
Ma, Yongmin, Zhou, T., Kong, X., Hider, R. C.   +3 more
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Antioxidant and Iron-chelating Agents in Cerebral Vasospasm

Neurosurgery, 1995
Prior work in our laboratory showed that the perivascular application of deferoxamine (an antioxidant and iron-chelating agent) inhibited delayed arterial narrowing after chronic blood exposure in a rat femoral artery model of vasospasm. To determine which of these mechanisms was operant in vasospasm, we compared deferoxamine with two agents (ascorbic ...
Z, Luo, T, Harada, S, London, C, Gajdusek, M R, Mayberg   +4 more
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Iron mobilization from transferrin by therapeutic iron chelating agents

Biochimica et Biophysica Acta (BBA) - General Subjects, 2012
The bacteriostatic activity of the transferrin family has been known since the early 1960's. The possession of high affinity iron(III)-binding sites and the existence of a specific membrane-bound receptor, have led to the present understanding of serum transferrin acting as the major iron transporter between cells in vertebrate systems.
Evans, Robert W., Kong, Xiaole, Hider, Robert C.   +2 more
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Iron-chelating agents and the reductive removal of iron from transferrin

Biochemical Pharmacology, 1980
Abstract 2-Formylpyridine thiosemicarbazone, a strong iron (II) and iron(III)-chelating agent, removed iron from transferrin only under reductive conditions. The reaction required a bicarbonate-labilizing anion such as nitrilotriacetate in order for reduction and release of iron to the thiosemicarbazone to occur.
E, Ankel, D H, Petering
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Iron chelating agents with clinical potential

Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences, 1992
Synopsis:Iron is a critically important metal for a wide variety of cellular events. The element holds this central position by virtue of its facile redox chemistry and the high affinity of both redox states (iron II and iron III) for oxygen. These same properties also render iron toxic when levels exceed the normal binding capacity of the cell.
R. C. Hider, S. Singh, J. B. Porter
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The Behaviour of Iron Chelating Agents with Plants

Journal of Experimental Botany, 1965
The absorption by normal and iron-deficient bean plants of Fe and of ethylene diamine-bis-(orthohydroxyphenylacetic acid) (EDHPA) is described; and the metabolism in plants of this chelating agent and of ethylenediaminetetra-acetic acid (EDTA) is examined using 14C-labelled compounds.
D. G. HILL-COTTINGHAM, C. P. LLOYD-JONES
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