Results 211 to 220 of about 32,727 (251)
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Chelation of iron within the erythrocytic Plasmodium falciparum parasite by iron chelators
Molecular and Biochemical Parasitology, 1999To examine the site of action of antimalarial iron chelators, iron ligands were added to control erythrocytes and to erythrocytes parasitized with Plasmodium falciparum, and the concentration of intracellular labile iron was monitored with the fluorescent probe, calcein.
M, Loyevsky +5 more
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Hematology/Oncology Clinics of North America, 2008
Effective chelation therapy can prevent or reverse organ toxicity related to iron overload, yet cardiac complications and premature death continue to occur, largely related to difficulties with compliance in patients who receive parenteral therapy. The use of oral chelators may be able to overcome these difficulties and improve patient outcomes.
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Effective chelation therapy can prevent or reverse organ toxicity related to iron overload, yet cardiac complications and premature death continue to occur, largely related to difficulties with compliance in patients who receive parenteral therapy. The use of oral chelators may be able to overcome these difficulties and improve patient outcomes.
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Iron Chelation in Chemotherapy
2003Publisher Summary This chapter discusses the way accumulation of excessive amounts of iron results in the loss of tissue and organ functions. Excessive iron in specific tissue sites promotes infection, neoplasia, cardiomyopathy, arthropathy, and an array of endocrine and neurodegenerative diseases.
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Blood Reviews, 2002
In patients with transfusion-dependent anemias, iron accumulation is fatal in the absence of chelating therapy. Extended survival, free of most complications of iron overload is observed in patients treated with early, adequate parenteral deferoxamine.
L, Merson, N, Olivier
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In patients with transfusion-dependent anemias, iron accumulation is fatal in the absence of chelating therapy. Extended survival, free of most complications of iron overload is observed in patients treated with early, adequate parenteral deferoxamine.
L, Merson, N, Olivier
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Combined iron chelation therapy
Annals of the New York Academy of Sciences, 2010Patients with thalassemia major accumulate body iron over time as a consequence of continuous red blood cell transfusions which cause hepatic, endocrine, and cardiac complications. Despite the availability of three iron chelators, some patients fail to respond adequately to monotherapy with any of them. Combination therapy, consisting in the use of two
Galanello Renzo +5 more
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Iron Chelates in Soybean Exudate
Science, 1962Soybean exudates contain iron compounds which can be separated electrophoretically into anodic bands and eluted with water. Chromatography of the water extracts separated iron from chelating agents which were identified as malic acid and malonic acid. Hence organic acids seem to function in the translocation of iron in plants.
L O, Tiffin, J C, Brown
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Iron Chelators for the Treatment of Cancer
Current Medicinal Chemistry, 2012The study of iron chelators as anti-tumor agents is still in its infancy. Iron is important for cellular proliferation and this is demonstrated by observations that iron-depletion results in cell cycle arrest and also apoptosis. In addition, many iron chelators are known to inhibit ribonucleotide reductase, the iron-containing enzyme that is the rate ...
Yu, Yu +6 more
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International Journal for Vitamin and Nutrition Research, 2004
Iron amino acid chelates, such as iron glycinate chelates, have been developed to be used as food fortificants and therapeutic agents in the prevention and treatment of iron deficiency anemia. Ferrous bis-glycine chelate (FeBC), ferric tris-glycine chelate, ferric glycinate, and ferrous bis-glycinate hydrochloride are available commercially.
Eva, Hertrampf, Manuel, Olivares
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Iron amino acid chelates, such as iron glycinate chelates, have been developed to be used as food fortificants and therapeutic agents in the prevention and treatment of iron deficiency anemia. Ferrous bis-glycine chelate (FeBC), ferric tris-glycine chelate, ferric glycinate, and ferrous bis-glycinate hydrochloride are available commercially.
Eva, Hertrampf, Manuel, Olivares
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Iron Toxicity and Chelation Therapy
International Journal of Hematology, 2002Iron is an essential mineral for normal cellular physiology, but an excess can result in cell injury. Iron in low-molecular-weight forms may play a catalytic role in the initiation of free radical reactions. The resulting oxyradicals have the potential to damage cellular lipids, nucleic acids, proteins, and carbohydrates; the result is wide-ranging ...
Robert S, Britton +2 more
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Iron Chelation for Iron Overload in Thalassemia.
Metal ions in life sciences, 2019This chapter is devoted to the chelation treatment of transfusion-dependent thalassemia patients. After a brief overview on the pathophysiology of iron overload and on the methods to quantify it in different organs, the chelation therapy is discussed, giving particular attention to the chemical and biomedical requisites.
Guido Crisponi +2 more
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