Results 221 to 230 of about 3,189,219 (271)

Case Report on Acquired Hepatocerebral Degeneration

Progress in Neurology and Psychiatry, Volume 30, Issue 4, November 2026.
ABSTRACT Acquired hepatocerebral degeneration (AHD) is an uncommon neurological manifestation of chronic liver disease, most often associated with portosystemic shunting. The disorder is characterised by a combination of movement abnormalities, cognitive decline, and psychiatric disturbance. Manganese accumulation within the basal ganglia, secondary to
Aamir Khan, Odai Jumma, Taram Nayab
wiley   +1 more source

Liver iron concentration and renal dysfunction in β-thalassemia: a case series and exploratory clinical observations. [PDF]

Ann Hematol
Kabbara F, Charbel N, El Khoury S, Klim J, Ismail G, Ismail F, Fawaz H, Koussa S, Taher A.   +8 more
europepmc   +1 more source

A generalizable method for the purification and biophysical characterization of bacterial membrane receptors

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Membrane‐embedded bacterial receptors are challenging to express and purify in soluble form, yet their isolated domains are essential tools for structural and ligand‐discovery studies. Pseudomonas aeruginosa relies on the TonB‐dependent heme receptor HasR for iron acquisition, a process central to its pathogenicity.
Federico Bosetto, Maria Zacharopoulou, Mark Bycroft, Monika Kish, Giovanna Zinzalla, Pamela J. E. Rowling, Stephen H. McLaughlin, Jonathan J. Phillips, Laura S. Itzhaki, Ioanna Mela   +9 more
wiley   +1 more source

The role of iron in normal and impaired testicular function

Andrology, Volume 14, Issue 8, Page 2373-2387, November 2026.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Analysis of various electrocardiographic and echocardiographic parameters in beta thalassemia patients with iron overload. [PDF]

Ann Pediatr Cardiol
Girija H, Sridhar A, Muthukumaran CS, Ramkishore S, Ganesan R, Mahitha V, Arun V.   +6 more
europepmc   +1 more source

Contemporary Management of Thalassemia: A Perspective on Current Standards and the Emergence of FDA-Approved Oral Therapy. [PDF]

Health Sci Rep
Zainab F, Hasan AH, Abid MH, Abid MA.
europepmc   +1 more source

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Iron chelation therapy

European Journal of Haematology, 2023
AbstractIron overload is a pathological condition resulting from a congenital impairment of its regulation, increased intestinal iron absorption secondary to bone marrow erythroid hyperplasia, or a chronic transfusional regimen. In normal conditions, intracellular and systemic mechanisms contribute to maintaining iron balance.
Antonella Bruzzese, Enrica Antonia Martino, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Carlo Bova, Gianfranco Filippelli, Isabella Capodanno, Antonino Neri, Fortunato Morabito, Massimo Gentile, Ernesto Vigna   +11 more
openaire   +2 more sources

Iron chelators in cancer therapy

BioMetals, 2020
Iron chelators have long been a target of interest as anticancer agents. Iron is an important cellular resource involved in cell replication, metabolism and growth. Iron metabolism is modulated in cancer cells reflecting their increased replicative demands.
Ola Ibrahim, Jeff O’Sullivan
openaire   +2 more sources

Iron-Chelating Therapy

CRC Critical Reviews in Clinical Laboratory Sciences, 1988
Because of the catalytic action of iron in one-electron redox reactions, it has a key role in the formation of harmful oxygen derivatives and production of peroxidative damage to vital cellular structures. The clinical manifestations of iron overload may be prevented and even reversed by the effective administration of the iron-chelating drug ...
Chaim Hershko, David J. Weatherall, Clement Finch   +2 more
openaire   +2 more sources

CHELATE IRON THERAPY

Journal of the American Medical Association, 1958
Administration of effective doses of iron in the treatment of iron deficiency anemia is complicated by the fact that iron compounds are not innocuous. Toxicity experiments on dogs and rabbits are here summarized; they showed that the concentration of iron attained in the animal's serum determined the severity of the acute symptoms.
M, FRANKLIN, W G, ROHSE, J, DE LA HUERGA, C R, KEMP   +3 more
openaire   +2 more sources