Results 61 to 70 of about 910,855 (274)

Down-regulation of senescence marker protein 30 by iron-specific chelator deferoxamine drives cell senescence

, 2018
To our knowledge, this is the first study to report down-regulation of senescence marker protein 30 (SMP30) by iron-specific chelator deferoxamine (DFO) on FAO cell senescence, using a DNA microarray.
Nobuaki Hanawa (4901986), Rie Katsumata-Tsuboi (3703813), Mariko Uehara (3422516), Hirofumi Inoue (283053), Shi-Ichi Katsumata (4901989), Nobuyuki Takahashi (184337)   +5 more
core   +2 more sources

Growth curves of WT WP3 and the fur mutant in liquid 2216E with or without 60 µM iron chelator under aerobic conditions.

, 2013
(▪) WT WP3, (•) fur mutant, (▴) WT WP3 with 60 µM iron chelator, and (▾) fur mutant with 60 µM iron chelator. The data represent averages of triplicate cultures.
Xin-Wei Yang (122701), Ying He (125930), Xiang Xiao (44417), Jun Xu (45543), Feng-Ping Wang (466709)   +4 more
core   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Fenofibrate prevents iron induced activation of canonical Wnt/β-catenin and oxidative stress signaling in the retina

npj Aging and Mechanisms of Disease, 2020
Accumulating evidence strongly implicates iron in the pathogenesis of aging and disease. Iron levels have been found to increase with age in both the human and mouse retinas.
Ashok Mandala, Austin Armstrong, Becky Girresch, Jiyao Zhu, Aruna Chilakala, Sanmathi Chavalmane, Kapil Chaudhary, Pratim Biswas, Judith Ogilvie, Jaya P. Gnana-Prakasam   +9 more
doaj   +1 more source

“Limiting access to iron decreases infection of Atlantic salmon SHK-1 cells with bacterium Piscirickettsia salmonis”

BMC Veterinary Research, 2021
Background Vertebrate hosts limit the availability of iron to microbial pathogens in order to nutritionally starve the invaders. The impact of iron deficiency induced by the iron chelator deferoxamine mesylate (DFO) was investigated in Atlantic salmon ...
Rodrigo Díaz, José Troncoso, Eva Jakob, Stanko Skugor   +3 more
doaj   +1 more source

Deferitazole, a new orally active iron chelator

, 2015
Following a systematic search of desferrithiocin analogs, a polyether derivative, deferitazole (formerly FBS0701), has entered into phase 1 and 2 clinical trials with promising biological properties.
Abbate, Vincenzo; id_orcid, Hider, Robert Charles, Harland, Rachel, Kong, Xiaole, Luker, Tim, Conlon, Kelly   +5 more
core   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Complex interaction of deferasirox and Pythium insidiosum: iron-dependent attenuation of growth in vitro and immunotherapy-like enhancement of immune responses in vivo. [PDF]

PLoS ONE, 2015
Pythium insidiosum iron acquisition mechanisms are unknown. We previously showed that the iron chelator deferasirox had weak activity in vitro and in rabbits with experimental pythiosis. Here we show that deferasirox causes damage to P. insidiosum hyphae
Régis A Zanette, Paula E R Bitencourt, Dimitrios P Kontoyiannis, Rafael A Fighera, Mariana M Flores, Glaucia D Kommers, Priscila S Silva, Aline Ludwig, Maria B Moretto, Sydney H Alves, Janio M Santurio   +10 more
doaj   +1 more source

Ultrasound‐Activated Ce(IV)‐Integrated Biomimetic Nanoplatform for Oxygenation‐Reinforced Gas‐Sonodynamic Ferroptosis and cGAS–STING‐Driven Antitumor Immunity

Advanced Science, EarlyView.
A Ce(IV)‐integrated biomimetic nanoplatform coordinates tumor oxygenation, ultrasound‐triggered carbon monoxide release, sonodynamic therapy, ferroptosis amplification, and cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) immune activation.
Mengli Ma, Yingying Wu, Yunjie Wang, Yang Li, Yijia Zhang, Zhibo Zhang, Jinzhi Peng, Xiangyu Wu, Yi Luo, Weijing Zhang, Xin Ye, Weisong Lai, Shengyu Wang, Dan Du, Wengang Li, Nan Zheng, Fanghong Luo, Ting Wu   +17 more
wiley   +1 more source

Deferiprone as adjunctive treatment for patients with invasive mucormycosis: A retrospective case series

Infectious Disease Reports, 2018
Mucormycosis is a life-threatening disease requiring multimodal treatment with antifungals and surgery. The mortality rate remains high, prompting consideration of alternative treatment strategies. Deferiprone has in vitro activity against Mucorales, but
Maria N. Chitasombat, Pimjai Niparuck
doaj   +1 more source