Results 211 to 220 of about 1,598,338 (286)

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

Endosomal TPC1-mediated Ca²⁺ nanodomains regulate transferrin receptor trafficking and iron homeostasis. [PDF]

Proc Natl Acad Sci U S A
Burton WJ, Lin A, Morgan AJ, Davis LC, Chen CC, Galione A.   +5 more
europepmc   +1 more source

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

Candidatus Bartonella xiongi influences iron homeostasis in the hematophagous mite Dermanyssus gallinae, affecting its reproduction. [PDF]

Commun Biol
Sun T, Liu Q, Wang P, Zhang Y, Chen W, Su D, Guo X, Wang B, Pan B.   +8 more
europepmc   +1 more source

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source

PEDV envelope protein promotes viral replication by remodeling host iron homeostasis via the TRIM28-KLF15-FPN axis. [PDF]

J Virol
Hu L, Tian R, Gao L, Xu N, Li P, Wang L, Fu X, Rong Z, Du M, Ma Y, Cheng Y, Han L, Ran X, Guan G, Zhou T, Chang L, Zhao X, Du Q, Huang Y, Tong D, Zhu M.   +20 more
europepmc   +1 more source

NDFIP2 Suppresses Colorectal Cancer Metastasis Through DDX3X‐Dependent R‐Loop Remodeling and GNG13 Transcriptional Activation

Advanced Science, EarlyView.
NDFIP2 recruits NEDD4 to promote K48‐linked ubiquitination and proteasomal degradation of DDX3X, leading to R‐loop accumulation and CTCF‐dependent suppression of GNG13 transcription. Consequently, PI3K/AKT signaling, EMT, stemness, and colorectal cancer metastasis are inhibited.
Enjian Zhang, Yanfang Li, Jiaxin Shu, Shang Xu, Heng Lv, Chong Zhang, Pengbo Zhang, Nai Wu, Shuai Gong, Xiuzhong Zhang, Zeqiang Ren, Xin Liu, Yi Zhang   +12 more
wiley   +1 more source

Participation of the Transcriptional Regulator Fur in Modulating Biofilm Formation of the Salmonid Pathogen <i>Yersinia ruckeri</i>: Beyond Iron Homeostasis. [PDF]

Int J Mol Sci
Peñaloza D, Barros MJ, Cabezas-Mera F, Acuña LG, Vásquez-Arriagada P, Parra F, Queraltó C, Silva C, Díaz S, Ubilla C, Moya-Beltrán A, Silva A, Nevermann J, Parada P, Gil F, Fuentes JA, Calderón IL.   +16 more
europepmc   +1 more source

The Interplay Between Molybdopterin Synthase and Metal Metabolism Contributes to Pathogenicity in Acinetobacter baumannii

Advanced Science, EarlyView.
Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao, Wenbo He, Zhenlin Ouyang, Ruochen Wang, Jiaxin Zhang, Xin Liu, Yiting Jing, Qinyue Yu, Xiaoyu He, Qian Qin, Litao Guo, Peter M. Hwang, Fang Zheng, Yurong Wen   +13 more
wiley   +1 more source