Results 261 to 270 of about 1,598,338 (286)

Regulation of iron homeostasis by microRNAs

Cellular and Molecular Life Sciences, 2012
Iron homeostasis is maintained at the cellular and systemic levels to assure adequate iron supply while preventing iron overload. The identification of genes mutated in patients with iron-related disorders or animal models with imbalances of iron homeostasis gave insight into the molecular mechanisms underlying processes critical for balancing iron ...
Mirco, Castoldi, Martina U, Muckenthaler
openaire   +2 more sources

Regulation of mammalian iron homeostasis

Current Opinion in Clinical Nutrition and Metabolic Care, 2000
Iron homeostasis is regulated with respect to uptake, storage and utilization. Newer work is presented that defines proteins responsible for iron transport, sequestration and sensing, and that addresses their regulation at the cellular and organismal levels by ambient iron concentrations, demand for erythropoiesis, body iron burden, and redox stimuli.
B D, Schneider, E A, Leibold
openaire   +2 more sources

Cellular Iron Homeostasis

Iron is an essential nutrient for all eukaryotic cells, yet it is potentially toxic. Cells have elegant systems coordinating the uptake, use, storage, and export of this metal while also responding to extracellular cues for regulating uptake and efflux.
Caroline C, Philpott, Esther G, Meyron-Holtz   +1 more
openaire   +2 more sources

Iron homeostasis in chronic inflammation

Acta Physiologica Hungarica, 2007
Inflammation induced anemia and resistance to erythropoietin are common features in patients with chronic kidney disease (CKD). Elevated levels of cytokines and enhanced oxidative stress, conditions associated with inflammatory states, are implicated in the development of anemia.
Balla, J., Jeney, V., Varga, Zs., Komódi, E., Nagy, E., Balla, Gy.   +5 more
openaire   +3 more sources

Metabolic surgery and iron homeostasis

Obesity Reviews, 2018
SummaryIron deficiency and anaemia after metabolic surgery, potentially modifiable nutritional complications, are becoming an increasing cause for concern as prevalence increases with time and there is limited evidence supporting the effectiveness of the current guidelines for prophylactic oral iron supplementation and treatment for deficiency ...
Peter N. Benotti, G Craig Wood, Christopher D. Still, Glenn S. Gerhard, David D. Rolston, Bruce R. Bistrian   +5 more
openaire   +2 more sources

Pregnancy and iron homeostasis: an update

Nutrition Reviews, 2013
It has been nearly 15 years since the first review on pregnancy and iron deficiency was published in Nutrition Reviews. Many unresolved issues raised in that seminal review have been addressed. New proteins involved in nonheme and heme iron transport have been identified in the enterocyte, and information on the roles of these proteins in the placenta ...
Chang, Cao, Kimberly O, O'Brien
openaire   +2 more sources

A genetic view of iron homeostasis

Seminars in Hematology, 2002
Inherited disorders of iron metabolism are invariably disorders of iron balance or distribution. This review describes the proteins known to be involved in establishing and maintaining iron balance, and discusses regulation of iron homeostasis in the context of three cell types: intestinal enterocytes, reticuloendothelial macrophages, and hepatocytes ...
openaire   +2 more sources

Regulation of systemic iron homeostasis

Current Opinion in Hematology, 2013
The circulating peptide hepcidin modulates systemic iron balance by limiting the absorption of dietary iron and the release of iron from macrophage stores. Recent studies conducted in humans, animal models, and tissue culture systems have enhanced our understanding of the molecular mechanisms by which hepcidin levels are altered in response to iron ...
openaire   +2 more sources

Cytokines, Iron Homeostasis, and Cancer

1994
Iron is of central importance to all, from bacteria to higher eukaryotes.1–3 It is critical for such important cellular processes as DNA synthesis, cellular respiration, and oxygen transport. However, iron also is a catalytic participant in the generation of damaging oxygen free radicals.
F M, Torti, S V, Torti
openaire   +2 more sources

Iron-homeostasis and obesity

Journal of Trace Elements in Medicine and Biology, 2015
Christiane, Becker, Klaus, Schümann
openaire   +2 more sources