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Orchestration of Iron Homeostasis
New England Journal of Medicine, 2005The characterization of newly identified genes has led investigators to challenge previous models of the regulation of iron homeostasis in health and its dysregulation in disease. Drs. Robert Fleming and Bruce Bacon describe hepcidin and iron homeostasis.
Robert E Fleming, Bruce R Bacon
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Iron Homeostasis and Organismal Aging
Ageing Research Reviews, 2021Iron is indispensable for normal body functions across species because of its critical roles in red blood cell function and many essential proteins and enzymes required for numerous physiological processes. Regulation of iron homeostasis is an intricate process involving multiple modulators at the systemic, cellular, and molecular levels. Interestingly,
Rui Xiao +2 more
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Annual Review of Physiology, 2007
Iron is needed by all mammalian cells but is toxic in excess. Specialized transport mechanisms conduct iron across cellular membranes. These are regulated to ensure homeostasis both systemically in living organisms and within individual cells. Over the past decade, major advances have been made in identifying and characterizing the proteins involved in
Nancy C, Andrews, Paul J, Schmidt
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Iron is needed by all mammalian cells but is toxic in excess. Specialized transport mechanisms conduct iron across cellular membranes. These are regulated to ensure homeostasis both systemically in living organisms and within individual cells. Over the past decade, major advances have been made in identifying and characterizing the proteins involved in
Nancy C, Andrews, Paul J, Schmidt
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Journal of Inorganic Biochemistry, 1992
The anatomical and cellular distribution of non-haem iron, ferritin, transferrin, and the transferrin receptor have been studied in postmortem human brain and these studies, together with data on the uptake and transport of labeled iron, by the rat brain, have been used to elucidate the role of iron and other metal ions in certain neurological ...
C M, Morris +8 more
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The anatomical and cellular distribution of non-haem iron, ferritin, transferrin, and the transferrin receptor have been studied in postmortem human brain and these studies, together with data on the uptake and transport of labeled iron, by the rat brain, have been used to elucidate the role of iron and other metal ions in certain neurological ...
C M, Morris +8 more
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Comprehensive Physiology, 2013
Abstract Iron is an essential nutrient that is tightly regulated. A principal function of the liver is the regulation of iron homeostasis. The liver senses changes in systemic iron requirements and can regulate iron concentrations in a robust and rapid manner. The last 10 years have led to the discovery of several
Erik R, Anderson, Yatrik M, Shah
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Abstract Iron is an essential nutrient that is tightly regulated. A principal function of the liver is the regulation of iron homeostasis. The liver senses changes in systemic iron requirements and can regulate iron concentrations in a robust and rapid manner. The last 10 years have led to the discovery of several
Erik R, Anderson, Yatrik M, Shah
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Current Opinion in Clinical Nutrition & Metabolic Care, 2016
Iron is essential for normal cellular function and many diseases result from disturbances in iron homeostasis. This review describes some of the recent key advances in iron transport and its regulation, how this relates to iron-related disorders, and emerging therapies for these diseases.The iron-regulatory hormone hepcidin and its target, the iron ...
Shanshan, Guo +2 more
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Iron is essential for normal cellular function and many diseases result from disturbances in iron homeostasis. This review describes some of the recent key advances in iron transport and its regulation, how this relates to iron-related disorders, and emerging therapies for these diseases.The iron-regulatory hormone hepcidin and its target, the iron ...
Shanshan, Guo +2 more
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Iron Homeostasis in the Neonate
Pediatrics, 2009The regulation of the availability of micronutrients is particularly critical during periods of rapid growth and differentiation such as the fetal and neonatal stages. Both iron deficiency and excess during the early weeks of life can have severe effects on neurodevelopment that may persist into adulthood and may not be corrected by restoration of ...
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Science's STKE, 2001
Hemochromatosis (HH) is a human disease characterized by an overload of iron in the plasma and multiple organs. The mouse model of HH is the result of a mutation in the HFE gene, which encodes a protein that interacts with the transferrin receptor.
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Hemochromatosis (HH) is a human disease characterized by an overload of iron in the plasma and multiple organs. The mouse model of HH is the result of a mutation in the HFE gene, which encodes a protein that interacts with the transferrin receptor.
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Physiological Reviews, 2013
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.
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The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.
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Homing in on iron homeostasis in plants
Trends in Plant Science, 2009Iron is essential for plants but is not readily accessible and is also potentially toxic. As plants are a major dietary source of iron worldwide, understanding plant iron homeostasis is pivotal for improving not only crop yields but also human nutrition.
Jeeyon, Jeong, Mary Lou, Guerinot
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