CHIR99021 Maintenance of the Cell Stemness by Regulating Cellular Iron Metabolism
Antioxidants, 2023 CHIR99021 is an aminopyrimidine derivative, which can efficiently inhibit the activity of glycogen synthesis kinase 3α (GSK-3α) and GSK-3β. As an essential component of stem cell culture medium, it plays an important role in maintaining cell stemness ...
Yingying Han +8 more
doaj +1 more source
Snapshot of iron response in by gene network reconstruction [PDF]
, 2009 Background Iron homeostasis of Shewanella oneidensis, a γ-proteobacterium possessing high iron content, is regulated by a global transcription factor Fur.
Yunfeng Yang +11 more
core +1 more source
Inflammation, dysregulated iron metabolism, and cardiovascular disease
Frontiers in Aging, 2023 Iron is an essential trace element associated with both pathologic deficiency and toxic overload. Thus, systemic and cell iron metabolism are highly controlled processes regulated by protein expression and localization, as well as turnover, through the ...
Shaina L. Rosenblum
doaj +1 more source
Identification of erythroferrone as an erythroid regulator of iron metabolism. [PDF]
, 2014 Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.
Ganz, Tomas +5 more
core +1 more source
Low Dose Daily Iron Supplementation Improves Iron Status and Appetite but not Anemia, Whereas Quarterly Anthelminthic Treatment Improves Growth, Appetite and Anemia in Zanzibari Preschool Children. [PDF]
, 2004 Iron deficiency and helminth infections are two common conditions of children in developing countries. The consequences of helminth infection in young children are not well described, and the efficacy of low dose iron supplementation is not well ...
Adam +53 more
core +1 more source
Iron Metabolism in Normal and Pathological Pregnancies and Fetal Consequences
Metabolites, 2022 Iron is required for energy production, DNA synthesis, and cell proliferation, mainly as a component of the prosthetic group in hemoproteins and as part of iron-sulfur clusters.
Charles Mégier +3 more
doaj +1 more source
Remnants of an ancient metabolism without phosphate [PDF]
, 2017 Phosphate is essential for all living systems, serving as a building block of genetic and metabolic machinery. However, it is unclear how phosphate could have assumed these central roles on primordial Earth, given its poor geochemical accessibility.
Goldford, Joshua E. +3 more
core +1 more source
De Toro, Alfonso; Ceballos, René (eds.) (2014).Frida Kahlo ‘revisitada’: Estrategias transmediales- transculturales - transpicturales. Hildesheim; Zürich; New York: Georg Olms Verlag, pp. 193 [PDF]
, 2015 Iron is an essential element, since it is a component of many macromolecules involved in diverse physiological and cellular functions, including oxygen transport, cellular growth, and metabolism.
Rishi, G. +3 more
core +2 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE [PDF]
, 2000 The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.
Andrews, Nancy C. +5 more
core +1 more source