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Iron overload disorders

Hepatology Communications, 2022
Iron overload disorders represent a variety of conditions that lead to increased total body iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron saturation can be commonly encountered in the evaluation of elevated liver ...
Christine C. Hsu, Nizar H. Senussi, Kleber Y. Fertrin, Kris V. Kowdley   +3 more
doaj   +3 more sources

Cardiac injury caused by iron overload in thalassemia [PDF]

Frontiers in Pediatrics
Cardiac iron overload affects approximately 25% of patients with β-thalassemia major, which is associated with increased morbidity and mortality.
Chunxi Fu, Chunxi Fu, Xue Yang, Xue Yang
doaj   +2 more sources

Iron overload is not the same everywhere: Particularities of iron-metabolism gene mutations in Brazil and a proposal for the investigation and management of iron overload in this population [PDF]

Hematology, Transfusion and Cell Therapy
There is no physiological mechanism for the excretion of iron in humans, and excess iron may lead to severe tissue damage if not adequately treated.
Paula de Melo Campos, Ana Carolina Toreli, Dulcinéia Martins de Albuquerque, Fernando Ferreira Costa   +3 more
doaj   +2 more sources

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke [PDF]

Advanced Science
Iron accumulation and ferroptosis occur in the brain following ischemic stroke. However, the relationship between iron overload and cell type‐specific fates remains largely unclear.
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
doaj   +2 more sources

The role of mitochondria in iron overload-induced damage [PDF]

Journal of Translational Medicine
Iron overload is a pathological condition characterized by the abnormal accumulation of iron within the body, which may result from excessive iron intake, disorders of iron metabolism, or specific disease states.
Yangyang Zhao, Mengjiao Yang, Xiaoxue Liang   +2 more
doaj   +2 more sources

The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading

Insights into Imaging, 2022
Objectives Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients.
Basant Mohamed Raief Mosaad, Ahmed Samir Ibrahim, Mohamed G. Mansour, Mohsen Saleh ElAlfy, Fatma Soliman Elsayed Ebeid, Emad H. Abdeldayem   +5 more
doaj   +1 more source

Iron Overload in a Patient with Non-Transfusion-Dependent Hemoglobin H Disease and Borderline Serum Ferritin: Can We Rely on Serum Ferritin for Monitoring in This Group of Patients?

Case Reports in Oncology, 2020
Secondary iron overload is a common complication in the context of hematological diseases, as iron accumulates due to different mechanisms including chronic transfusion, increased gastrointestinal absorption, chronic hemolysis and underlying genetic ...
Mohammad Ali, Mohamed A. Yassin, Maya Aldeeb   +2 more
doaj   +1 more source

Extensive iron overload in bone marrow: A cause of pancytopenia in a thalassemia major patient – A case report

Asian Journal of Transfusion Science, 2020
Iron overload-associated organ damage in transfusion-dependent anemias is a well-known phenomenon. Here, we discuss a case of 28-year-old, poorly chelated thalassemia major patient, whose blood workup revealed pancytopenia and moderately raised serum ...
Maria Ali, Sidra Asad Ali, Huma Mansoori
doaj   +1 more source

Females Are Protected From Iron‐Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundSex‐related differences in cardiac function and iron metabolism exist in humans and experimental animals. Male patients and preclinical animal models are more susceptible to cardiomyopathies and heart failure.
Subhash K. Das, Vaibhav B. Patel, Ratnadeep Basu, Wang Wang, Jessica DesAulniers, Zamaneh Kassiri, Gavin Y. Oudit   +6 more
doaj   +1 more source

Iron-overload myopathy [PDF]

International Journal of Hematology, 2011
A 66-year-old male patient presented with a 4-month history of progressive muscle weakness. Twelve years prior to presentation he was evaluated for fatigue, weight loss, new-onset diabetes and elevated liver enzymes and was diagnosed with hereditary hemochromatosis, homozygous for the C282Y mutation in the HFE gene.
Javier, Munoz, Natalia, Ferrari, Philip, Kuriakose   +2 more
openaire   +2 more sources