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Iron overload disorders

Hepatology Communications, 2022
Iron overload disorders represent a variety of conditions that lead to increased total body iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron saturation can be commonly encountered in the evaluation of elevated liver ...
Christine C. Hsu, Nizar H. Senussi, Kleber Y. Fertrin, Kris V. Kowdley   +3 more
doaj   +4 more sources

Baicalein Alleviates Iron Overload-Induced Ferroptosis and Osteogenic Blockade in Osteoblasts by Activating the Nrf2/GPX4 Pathway [PDF]

BME Frontiers
Objective: This study aimed to investigate the protective effects and underlying mechanisms of baicalein against iron overload-induced osteoblast dysfunction and bone loss.
Zengfeng Guo, Ningfeng Zhang, Junshen Huang, Wang Zhang, Yawei Hu, Shaochu Chen, Ming Gong, Jianhua Zhou, Jiancheng Yang, Jiawen Wu   +9 more
doaj   +2 more sources

Inherited iron overload disorders [PDF]

Translational Gastroenterology and Hepatology, 2020
Hereditary iron overload includes several disorders characterized by iron accumulation in tissues, organs, or even single cells or subcellular compartments. They are determined by mutations in genes directly involved in hepcidin regulation, cellular iron uptake, management and export, iron transport and storage.
Piperno, Alberto, Pelucchi, Sara, Mariani, Raffaella   +2 more
openaire   +4 more sources

Cardiac injury caused by iron overload in thalassemia [PDF]

Frontiers in Pediatrics
Cardiac iron overload affects approximately 25% of patients with β-thalassemia major, which is associated with increased morbidity and mortality.
Chunxi Fu, Chunxi Fu, Xue Yang, Xue Yang
doaj   +2 more sources

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke [PDF]

Advanced Science
Iron accumulation and ferroptosis occur in the brain following ischemic stroke. However, the relationship between iron overload and cell type‐specific fates remains largely unclear.
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
doaj   +2 more sources

Oxidative stress induces mitochondrial iron overload and ferroptotic cell death

Scientific Reports, 2023
Oxidative stress has been shown to induce cell death in a wide range of human diseases including cardiac ischemia/reperfusion injury, drug induced cardiotoxicity, and heart failure. However, the mechanism of cell death induced by oxidative stress remains
Yi Chen, Xiaoyun Guo, Yachang Zeng, Xiaoliang Mo, Siqi Hong, Hui He, Jing Li, Sulail Fatima, Qinghang Liu   +8 more
semanticscholar   +1 more source

Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR.

Radiology, 2023
Accumulation of excess iron in the body, or systemic iron overload, results from a variety of causes. The concentration of iron in the liver is linearly related to the total body iron stores and, for this reason, quantification of liver iron ...
S. Reeder, T. Yokoo, M. França, D. Hernando, Á. Alberich-Bayarri, J. Alústiza, Y. Gandon, B. Henninger, C. Hillenbrand, K. Jhaveri, M. Karçaaltınçaba, J. Kühn, A. Mojtahed, S. Serai, Richard Ward, John C. Wood, J. Yamamura, L. Martí-Bonmatí   +17 more
semanticscholar   +1 more source

Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2/System xc-/GPX4 axis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
BACKGROUND Iron homeostasis plays a positive role in articular cartilage health. Excessive iron or iron overload can induce oxidative stress damage in chondrocytes and ferroptosis cell death, advancing knee osteoarthritis (KOA).
Qi He, Junzheng Yang, Zhaofeng Pan, Gangyu Zhang, Baihao Chen, Shaocong Li, Jiacong Xiao, Fengjin Tan, Zihao Wang, Peng Chen, Haibin Wang   +10 more
semanticscholar   +1 more source

Iron Chelators in Treatment of Iron Overload

Journal of Toxicology, 2022
Patients suffering from iron overload can experience serious complications. In such patients, various organs, such as endocrine glands and liver, can be damaged.
Sarina Entezari, Seyedeh Mona Haghi, Narges Norouzkhani, Barsa Sahebnazar, Fatemeh Vosoughian, Diba Akbarzadeh, Muhammad Islampanah, Navid Naghsh, Mohammad Abbasalizadeh, N. Deravi   +9 more
semanticscholar   +1 more source

Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.

Free Radical Biology & Medicine, 2022
Iron overload is a common phenomenon in the elderly population. Many clinical studies have indicated an association between iron overload and the incidence and pathological progression of intervertebral disc degeneration (IVDD).
Wenchao Wang, Xingzhi Jing, Ting Du, Jiabin Ren, Xiaoyang Liu, Feifei Chen, Yuandong Shao, Shengyao Sun, Guihe Yang, Xingang Cui   +9 more
semanticscholar   +1 more source