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Hepatology Communications, 2022 Iron overload disorders represent a variety of conditions that lead to increased total body iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron saturation can be commonly encountered in the evaluation of elevated liver ...
Christine C. Hsu +3 more
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Cardiac injury caused by iron overload in thalassemia [PDF]
Frontiers in PediatricsCardiac iron overload affects approximately 25% of patients with β-thalassemia major, which is associated with increased morbidity and mortality.
Chunxi Fu, Chunxi Fu, Xue Yang, Xue Yang
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Iron overload in Montpelier [PDF]
Gut, 2001 See article on page 836 Since the original discovery of the haemochromatosis gene (HFE) in 1996,1 there have been two genetic mutations that have dominated clinical studies. The C282Y mutation (845 G→A) has attracted the most attention as the majority of typical haemochromatosis patients are homozygotes for this mutation. This has increasingly led to
Paul C. Adams
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Nrf2 activators for the treatment of rare iron overload diseases: From bench to bedside [PDF]
Redox BiologyIron overload and related oxidative damage are seen in many rare diseases, due to mutation of iron homeostasis-related genes. As a core regulator on cellular antioxidant reaction, Nrf2 can also decrease systemic and cellular iron levels by regulating ...
Yimin Dong +5 more
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Iron overload is not the same everywhere: Particularities of iron-metabolism gene mutations in Brazil and a proposal for the investigation and management of iron overload in this population [PDF]
Hematology, Transfusion and Cell TherapyThere is no physiological mechanism for the excretion of iron in humans, and excess iron may lead to severe tissue damage if not adequately treated.
Paula de Melo Campos +3 more
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The role of mitochondria in iron overload-induced damage [PDF]
Journal of Translational MedicineIron overload is a pathological condition characterized by the abnormal accumulation of iron within the body, which may result from excessive iron intake, disorders of iron metabolism, or specific disease states.
Yangyang Zhao +2 more
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Parkin inhibits iron overload-induced cardiomyocyte ferroptosis by ubiquitinating ACSL4 and modulating PUFA-phospholipids metabolism [PDF]
Acta Pharmaceutica Sinica BIron overload is strongly associated with heart disease. Ferroptosis is a new form of regulated cell death indicated in cardiac ischemia–reperfusion (I/R) injury.
Dandan Xiao +12 more
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Insights into Imaging, 2022 Objectives Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients.
Basant Mohamed Raief Mosaad +5 more
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Case Reports in Oncology, 2020 Secondary iron overload is a common complication in the context of hematological diseases, as iron accumulates due to different mechanisms including chronic transfusion, increased gastrointestinal absorption, chronic hemolysis and underlying genetic ...
Mohammad Ali +2 more
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