Results 11 to 20 of about 1,317,788 (302)

The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading

Insights into Imaging, 2022
Objectives Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients.
Basant Mohamed Raief Mosaad, Ahmed Samir Ibrahim, Mohamed G. Mansour, Mohsen Saleh ElAlfy, Fatma Soliman Elsayed Ebeid, Emad H. Abdeldayem   +5 more
doaj   +1 more source

PPARα alleviates iron overload‐induced ferroptosis in mouse liver

EMBO Reports, 2022
Ferroptosis is an iron‐dependent form of non‐apoptotic cell death implicated in liver, brain, kidney, and heart pathology. How ferroptosis is regulated remains poorly understood. Here, we show that PPARα suppresses ferroptosis by promoting the expression
Guowei Xing, Lihua Meng, Shiyao Cao, Shenghui Liu, Jiayan Wu, Qian Li, Wendong Huang, Lisheng Zhang   +7 more
semanticscholar   +1 more source

Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis

Redox Biology, 2021
Ferroptosis plays a role in several diseases such as iron overload-induced liver diseases. Manipulation of ferroptosis has been explored as a potential therapeutic strategy to treat related diseases.
Aimin Wu, B. Feng, Jie Yu, Lijun Yan, L. Che, Y. Zhuo, Yuheng Luo, B. Yu, De Wu, Daiwen Chen   +9 more
semanticscholar   +1 more source

The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis

Biomolecules, 2022
Ferroptosis is a new type of cell death caused by iron-dependent lipid peroxidation. In recent years, it has been found that ferroptosis can promote the progression of atherosclerosis (AS).
Jiedong Ma, Hongqi Zhang, Yufei Chen, Xiaojin Liu, Jiamin Tian, Wei Shen   +5 more
semanticscholar   +1 more source

Iron overload in the motor cortex induces neuronal ferroptosis following spinal cord injury

Redox Biology, 2021
Motor neuron death is supposed to result in primary motor cortex atrophy after spinal cord injury (SCI), which is relevant to poorer motor recovery for patients with SCI. However, the exact mechanisms of motor neuron death remain elusive.
Zhou Feng, Ling-xia Min, Hui Chen, W. Deng, M. Tan, Hong-liang Liu, J. Hou   +6 more
semanticscholar   +1 more source

Iron Overload, Oxidative Stress, and Ferroptosis in the Failing Heart and Liver

Antioxidants, 2021
Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the impairment of redox homeostasis and cellular death. Iron overload is often associated with haematological diseases which require regular blood transfusion/phlebotomy, and ...
D. Mancardi, Mariarosa Mezzanotte, E. Arrigo, A. Barinotti, A. Roetto   +4 more
semanticscholar   +1 more source

Iron Overload Is Associated With Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis

Frontiers in Cell and Developmental Biology, 2021
Objective: Iron overload is common in elderly people which is associated with an increased prevalence of osteoarthritis (OA), but the exact role of iron in the development of OA has not been established.
Xingzhi Jing, Jiamin Lin, Ting Du, Zhensong Jiang, Tao Li, Guodong Wang, Xiaoyang Liu, Xingang Cui, Kai Sun   +8 more
semanticscholar   +1 more source

Iron Overload in a Patient with Non-Transfusion-Dependent Hemoglobin H Disease and Borderline Serum Ferritin: Can We Rely on Serum Ferritin for Monitoring in This Group of Patients?

Case Reports in Oncology, 2020
Secondary iron overload is a common complication in the context of hematological diseases, as iron accumulates due to different mechanisms including chronic transfusion, increased gastrointestinal absorption, chronic hemolysis and underlying genetic ...
Mohammad Ali, Mohamed A. Yassin, Maya Aldeeb   +2 more
doaj   +1 more source

The Evaluation Of Iron Deficiency And Iron Overload.

Deutsches Ärzteblatt International, 2021
BACKGROUND In the western world, 2-5% of women of child-bearing age suffer from irondeficiency anemia. Iron overload due to chronic treatment with blood transfusions or hereditary hemochromatosis is much rarer. METHODS This review is based on pertinent
N. Gattermann, M. Muckenthaler, A. Kulozik, G. Metzgeroth, J. Hastka   +4 more
semanticscholar   +1 more source

The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation

International Journal of Molecular Sciences, 2022
Intestinal homeostasis is maintained through the interplay of the intestinal mucosa, local and systemic immune factors, and the microbial content of the gut.
Caiyun Huo, Guiping Li, Yanxin Hu, Huiling Sun   +3 more
semanticscholar   +1 more source