Results 11 to 20 of about 48,493 (287)
Asian Journal of Transfusion Science, 2020 Iron overload-associated organ damage in transfusion-dependent anemias is a well-known phenomenon. Here, we discuss a case of 28-year-old, poorly chelated thalassemia major patient, whose blood workup revealed pancytopenia and moderately raised serum ...
Maria Ali, Sidra Asad Ali, Huma Mansoori
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundSex‐related differences in cardiac function and iron metabolism exist in humans and experimental animals. Male patients and preclinical animal models are more susceptible to cardiomyopathies and heart failure.
Subhash K. Das +6 more
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Iron overload and chelation [PDF]
Hematology, 2005 Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication.
Z. Ioav Cabantchik +3 more
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Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow
Brazilian Journal of Medical and Biological Research, 2017 Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with
J.C. Shen, Y.C. Zhang, M.F. Zhao
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The Egyptian Journal of Radiology and Nuclear Medicine, 2018 Aim of the study: The aim of this study was to assess the utility of MRI as a non-invasive technique for grading of the hepatic and cardiac iron overload in Thalassemia patients in a cohort of patients in Alexandria, Egypt.
Sara K. Elfawal +2 more
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Orchestrated regulation of iron trafficking proteins in the kidney during iron overload facilitates systemic iron retention. [PDF]
PLoS ONE, 2018 The exact route of iron through the kidney and its regulation during iron overload are not completely elucidated. Under physiologic conditions, non-transferrin and transferrin bound iron passes the glomerular filter and is reabsorbed through kidney ...
Avital Weiss +11 more
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Revista Brasileira de Hematologia e Hemoterapia, 2013 OBJECTIVE: The aim of this study was to evaluate the impact of iron overload on the profile of interleukin-10 levels, biochemical parameters and oxidative stress in sickle cell anemia patients.
Maritza Cavalcante Barbosa +5 more
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Antioxidants, 2022 Hemoglobin and iron overload is considered the major contributor to intracerebral hemorrhage (ICH)-induced brain injury. Accumulation of iron in the brain leads to microglia activation, inflammation and cell loss.
Giuseppe Carota +15 more
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Iron overload and immunity [PDF]
World Journal of Gastroenterology, 2007 Progress in the characterization of genes involved in the control of iron homeostasis in humans and in mice has improved the definition of iron overload and of the cells affected by it. The cell involved in iron overload with the greatest effect on immunity is the macrophage.
Maria de Sousa, Graça Porto
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Current Review of Iron Overload and Related Complications in Hematopoietic Stem Cell Transplantation
Turkish Journal of Hematology, 2017 Iron overload is an adverse prognostic factor for patients undergoing hematopoietic stem cell transplantation (HSCT). In the HSCT setting, pretransplant and early posttransplant ferritin and transferrin saturation were found to be highly elevated due to ...
Erden Atilla +2 more
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