Results 21 to 30 of about 129,076 (346)

Assessment of hepatic and cardiac iron overload in thalassemia patients by magnetic resonance imaging: Our experience in Alexandria University

The Egyptian Journal of Radiology and Nuclear Medicine, 2018
Aim of the study: The aim of this study was to assess the utility of MRI as a non-invasive technique for grading of the hepatic and cardiac iron overload in Thalassemia patients in a cohort of patients in Alexandria, Egypt.
Sara K. Elfawal, Doaa M. Emara, Ahmed A. Shehata   +2 more
doaj   +1 more source

Identification of erythroferrone as an erythroid regulator of iron metabolism. [PDF]

, 2014
Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.
Ganz, Tomas, Jung, Grace, Kautz, Léon, Nemeth, Elizabeta, Rivella, Stefano, Valore, Erika V   +5 more
core   +1 more source

Iron Overload Favors the Elimination of Leishmania [PDF]

, 2013
Iron plays a central role in host-parasite interactions, since both intervenients need iron for survival and growth, but are sensitive to iron-mediated toxicity. The host’s iron overload is often associated with susceptibility to infection. However, it
Appelberg, Rui, Gomes Pereira, Sandra Isabel, Gomes, Maria Salomé, Rodrigues, Pedro Nuno, Rosa, Gustavo, Teixeira, Carlos Miguel, Tomás, Ana, Vale-Costa, Sílvia   +7 more
core   +4 more sources

Neuroprotective Role of α-Lipoic Acid in Iron-Overload-Mediated Toxicity and Inflammation in In Vitro and In Vivo Models

Antioxidants, 2022
Hemoglobin and iron overload is considered the major contributor to intracerebral hemorrhage (ICH)-induced brain injury. Accumulation of iron in the brain leads to microglia activation, inflammation and cell loss.
Giuseppe Carota, Alfio Distefano, Mariarita Spampinato, Cesarina Giallongo, Giuseppe Broggi, Lucia Longhitano, Giuseppe A. Palumbo, Rosalba Parenti, Rosario Caltabiano, Sebastiano Giallongo, Michelino Di Rosa, Riccardo Polosa, Vincenzo Bramanti, Nunzio Vicario, Giovanni Li Volti, Daniele Tibullo   +15 more
doaj   +1 more source

Orchestrated regulation of iron trafficking proteins in the kidney during iron overload facilitates systemic iron retention. [PDF]

PLoS ONE, 2018
The exact route of iron through the kidney and its regulation during iron overload are not completely elucidated. Under physiologic conditions, non-transferrin and transferrin bound iron passes the glomerular filter and is reabsorbed through kidney ...
Avital Weiss, Lior Spektor, Lyora A Cohen, Lena Lifshitz, Inbar Magid Gold, De-Liang Zhang, Marianna Truman-Rosentsvit, Yael Leichtmann-Bardoogo, Abraham Nyska, Sefi Addadi, Tracey A Rouault, Esther G Meyron-Holtz   +11 more
doaj   +1 more source

Iron overload across the spectrum of non-transfusion-dependent thalassaemias: role of erythropoiesis, splenectomy and transfusions [PDF]

, 2017
Non-transfusion-dependent thalassaemias (NTDT) encompass a spectrum of anaemias rarely requiring blood transfusions. Increased iron absorption, driven by hepcidin suppression secondary to erythron expansion, initially causes intrahepatic iron overload ...
Bansal, Brissot, Cabantchik, Dussiot, Esposito, Fucharoen, Fucharoen, Galanello, Galanello, Gardenghi, Harteveld, Kautz, Lal, Lal, Loreal, Musallam, Musallam, Musallam, Musallam, O'Donnell, Origa, Pakbaz, Pasricha, Pippard, Pootrakul, Porter, Premawardhena, Rees, Ricchi, St Pierre, Taher, Taher, Taher, Taher, Taher, Taher, Tanno, Tanno, Vichinsky, Vichinsky, Walter, Weatherall, Worwood   +42 more
core   +1 more source

Impact of iron overload on interleukin-10 levels, biochemical parameters and oxidative stress in patients with sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia, 2013
OBJECTIVE: The aim of this study was to evaluate the impact of iron overload on the profile of interleukin-10 levels, biochemical parameters and oxidative stress in sickle cell anemia patients.
Maritza Cavalcante Barbosa, Talyta Ellen Jesus dos Santos, Geane Félix de Souza, Lívia Coêlho de Assis, Max Victor Carioca Freitas, Romélia Pinheiro Gonçalves   +5 more
doaj   +3 more sources

Is iron overload associated with worse outcomes in patients with chronic liver disease undergoing liver transplantation?

Revista de Investigación Clínica
Background: Iron overload is frequent in patients with chronic liver disease, associated with shorter survival after liver transplantation in patients with hereditary hemochromatosis.
Sergio Rodriguez-Rodriguez, Antonio Olivas-Martínez, Jesus Delgado-de la Mora, Braulio Martinez-Benitez, Ignacio García-Juarez, Roberta Demichelis-Gómez   +5 more
doaj   +1 more source

Baroreflex function in conscious rats submitted to iron overload [PDF]

, 2005
Our hypothesis is that iron accumulated in tissue, rather than in serum, may compromise cardiovascular control. Male Fischer 344 rats weighing 180 to 220 g were divided into 2 groups.
Cardoso, Leonardo Máximo, Chianca-Junior, Deoclécio Alves, Colombari, Eduardo, Moraes, Márcio Flávio Dutra, Pedrosa, Maria Lúcia Silva, Silva, Marcelo Eustáquio   +5 more
core   +1 more source

Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine

Journal of Toxicology, 2018
Objective. The aim of our study is to compare the role of the new natural alternative (Quercetin) with the current iron-chelation therapy (Deferoxamine (DFO)) in the effect of iron overload on small intestinal tissues and to investigate the possible ...
Arwa A. El-Sheikh, Shimaa Hamed Ameen, Samaa Salah AbdEl-Fatah   +2 more
doaj   +1 more source