Results 21 to 30 of about 1,317,788 (302)
Asian Journal of Transfusion Science, 2020 Iron overload-associated organ damage in transfusion-dependent anemias is a well-known phenomenon. Here, we discuss a case of 28-year-old, poorly chelated thalassemia major patient, whose blood workup revealed pancytopenia and moderately raised serum ...
Maria Ali, Sidra Asad Ali, Huma Mansoori
doaj +1 more source
Advancement of science, 2022 Excess iron accumulation occurs in organs of patients with certain genetic disorders or after repeated transfusions. No physiological mechanism is available to excrete excess iron and iron overload to promote lipid peroxidation to induce ferroptosis ...
Wenya Feng +8 more
semanticscholar +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundSex‐related differences in cardiac function and iron metabolism exist in humans and experimental animals. Male patients and preclinical animal models are more susceptible to cardiomyopathies and heart failure.
Subhash K. Das +6 more
doaj +1 more source
International Journal of Hematology, 2011 A 66-year-old male patient presented with a 4-month history of progressive muscle weakness. Twelve years prior to presentation he was evaluated for fatigue, weight loss, new-onset diabetes and elevated liver enzymes and was diagnosed with hereditary hemochromatosis, homozygous for the C282Y mutation in the HFE gene.
Javier, Munoz +2 more
openaire +2 more sources
Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms
Frontiers in Cell and Developmental Biology, 2022 There are multiple diseases or conditions such as hereditary hemochromatosis, hemophilia, thalassemia, sickle cell disease, aging, and estrogen deficiency that can cause iron overload in the human body.
Chenhui Cai, Wenhui Hu, T. Chu
semanticscholar +1 more source
Role of Flavonoids in the Treatment of Iron Overload
Frontiers in Cell and Developmental Biology, 2021 Iron overload, a high risk factor for many diseases, is seen in almost all human chronic and common diseases. Iron chelating agents are often used for treatment but, at present, most of these have a narrow scope of application, obvious side effects, and ...
Xiaoming Wang +5 more
semanticscholar +1 more source
Macrophage extracellular traps aggravate iron overload‐related liver ischaemia/reperfusion injury
British Journal of Pharmacology, 2021 Macrophages regulate iron homeostasis in the liver and play important role in hepatic ischaemia/reperfusion (I/R) injury. This study investigates the role of macrophages in iron overload‐related hepatocyte damage during liver I/R.
Shan Wu +9 more
semanticscholar +1 more source
Iron Overload Induces Oxidative Stress, Cell Cycle Arrest and Apoptosis in Chondrocytes
Frontiers in Cell and Developmental Biology, 2022 Clinical and experimental evidence point to the presence of considerable links between arthropathy, osteoarthritis (OA) in particular, and iron overload possibly due to oxidative stress and tissue damage.
A. Karim +5 more
semanticscholar +1 more source
Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow
Brazilian Journal of Medical and Biological Research, 2017 Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with
J.C. Shen, Y.C. Zhang, M.F. Zhao
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Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1
Cell Death Discovery, 2021 Endometriosis is one of the most common disorders that causes infertility in women. Iron is overloaded in endometriosis peritoneal fluid (PF), with harmful effects on early embryo development.
Shishi Li +11 more
semanticscholar +1 more source