Results 31 to 40 of about 129,076 (346)

Bismuth coordination networks containing deferiprone: synthesis, characterisation, stability and antibacterial activity [PDF]

, 2015
A series of bismuth–dicarboxylate–deferiprone coordination networks have been prepared and structurally characterised. The new compounds have been demonstrated to release the iron overload drug deferiprone on treatment with PBS and have also been shown ...
An, Andrew D. Burrows, Andrews, Bland, Burrows, Furukawa, Gavin W. Roffe, Ge, Ge, Henry J. Windle, Horcajada, Janiak, John Spencer, Li, Lin, Lou, Mary F. Mahon, Miller, Monika Jurcic, Sandrine Pierrat, Schindler, Sox, Su, Tamames-Tabar, Thirumurugan, Thirumurugan, Thompson, Wibowo, Yang   +28 more
core   +1 more source

Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice

Journal of Advanced Research
Introduction: Iron overload disrupts gut microbiota and induces ferroptosis, contributing to colitis. However, whether gut microbiota directly drives iron overload-induced colitis and its underlying mechanism remain unclear.
Ke Gu, Aimin Wu, Chen Liu, Bing Yu, Jun He, Xin Lai, Junzhou Chen, Yuheng Luo, Hui Yan, Ping Zheng, Junqiu Luo, Junning Pu, Quyuan Wang, Huifen Wang, Daiwen Chen   +14 more
doaj   +1 more source

A European survey on the detection and management of iron overload in transfusion-dependent patients with MDS [PDF]

, 2011
International audienceTo better understand the detection and management of iron overload in transfusion-dependent patients with myelodysplastic syndromes (MDS), a 15-min web- or paper-based survey was conducted among 338 European physicians from 27 ...
Fenaux, Pierre,, Giagounidis, Aristoteles, Ille, Susanne, Leto Di Priolo, Susanna   +3 more
core   +4 more sources

Current Review of Iron Overload and Related Complications in Hematopoietic Stem Cell Transplantation

Turkish Journal of Hematology, 2017
Iron overload is an adverse prognostic factor for patients undergoing hematopoietic stem cell transplantation (HSCT). In the HSCT setting, pretransplant and early posttransplant ferritin and transferrin saturation were found to be highly elevated due to ...
Erden Atilla, Selami K. Toprak, Taner Demirer   +2 more
doaj   +1 more source

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis [PDF]

, 2014
Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional ...
Anderson, Denise, Benyamin, Beben, Broer, Linda, Esko, Tonu, Franke, Lude, Goegele, Martin, Haeldin, Jonas, Jolley, Jennifer, Kiemeney, Lambertus A., Kutalik, Zoltan, Luan, Jian'an, Meitinger, Thomas, Mihailov, Evelin, Milani, Lili, Peters, Annette, Podmore, Clara, Radhakrishnan, Aparna, Rendon, Augusto, Ried, Janina S., Sambrook, Jennifer, Sanna, Serena, Sweep, Fred C., Tanaka, Toshiko, Thiery, Joachim, Traglia, Michela, van der Meer, Peter, Vermeulen, Sita H., Waldenberger, Melanie, Wang, Fudi, Westra, Harm-Jan, Winkelmann, Juliane   +30 more
core   +1 more source

Iron Overload in Patients with Chronic Lymphocytic Leukemia Complicated by Autoimmune Hemolytic Anemia: A Case Report

Case Reports in Oncology, 2020
Iron overload is commonly seen in the context of hematological diseases in patients who require frequent transfusions. On the other hand, an association between autoimmune hemolytic anemia complicating chronic lymphocytic leukemia and iron overload is ...
Mohammad Ali, Mohamed A. Yassin
doaj   +1 more source

Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress [PDF]

, 2019
York University ...
Jahng, James Won Suk, Pantopoulos, Kostas, Song, Erfei, Sung, Hye Kyoung, Sweeney, Gary   +4 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Hospitalization causes due to iron overload in beta-Thalassemia in Gorgan, Iran [PDF]

, 2011
Objective: To evaluate causes of hospitalization (due to complications of iron overload and other causes) in beta-Thalassemic patients. Methodology: This study was performed on 244 patients with major beta-Thalassemia admitted in Taleghani hospital of ...
Jahazi, A., Mirbehbahani, N., Rahnama, M.S.   +2 more
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source