Results 31 to 40 of about 53,613 (303)

MOFs and COFs in Electronics: Bridging the Gap between Intrinsic Properties and Measured Performance

Advanced Functional Materials, EarlyView.
Metal‐organic frameworks (MOFs) and covalent organic frameworks (COFs) hold promise for advanced electronics. However, discrepancies in reported electrical conductivities highlight the importance of measurement methodologies. This review explores intrinsic charge transport mechanisms and extrinsic factors influencing performance, and critically ...
Jonas F. Pöhls, R. Thomas Weitz
wiley   +1 more source

A novel circPIK3C2A/miR‐31‐5p/TFRC axis drives ferroptosis and accelerates myocardial injury

MedComm
Iron overload is common in cardiovascular disease, it is also the factor that drives ferroptosis. Noncoding RNAs play an important role in heart disease; however, their regulatory role in iron overload‐mediated ferroptosis remains much unknown.
Shuo Miao, Lanting Yang, Tao Xu, Zhantao Liu, Yixiao Zhang, Lin Ding, Wei Ding, Xiang Ao, Jianxun Wang   +8 more
doaj   +1 more source

Parkin inhibits iron overload-induced cardiomyocyte ferroptosis by ubiquitinating ACSL4 and modulating PUFA-phospholipids metabolism

Acta Pharmaceutica Sinica B
Iron overload is strongly associated with heart disease. Ferroptosis is a new form of regulated cell death indicated in cardiac ischemia–reperfusion (I/R) injury.
Dandan Xiao, Wenguang Chang, Xiang Ao, Lin Ye, Weiwei Wu, Lin Song, Xiaosu Yuan, Luxin Feng, Peiyan Wang, Yu Wang, Yi Jia, Xiaopeng Tang, Jianxun Wang   +12 more
doaj   +1 more source

Evaluating renal iron overload in diabetes mellitus by blood oxygen level-dependent magnetic resonance imaging: a longitudinal experimental study

BMC Medical Imaging, 2022
Background Iron overload plays a critical role in the pathogenesis of diabetic nephropathy. Non-invasive evaluation of renal iron overload in diabetes in the management and intervention of diabetic nephropathy is of great significance.
Weiwei Geng, Liang Pan, Liwen Shen, Yuanyuan Sha, Jun Sun, Shengnan Yu, Jianguo Qiu, Wei Xing   +7 more
doaj   +1 more source

Inherited iron overload disorders [PDF]

Translational Gastroenterology and Hepatology, 2020
Hereditary iron overload includes several disorders characterized by iron accumulation in tissues, organs, or even single cells or subcellular compartments. They are determined by mutations in genes directly involved in hepcidin regulation, cellular iron uptake, management and export, iron transport and storage.
Piperno, Alberto, Pelucchi, Sara, Mariani, Raffaella   +2 more
openaire   +3 more sources

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

The corrected QT interval prolongation in adolescents with cardiac iron overload β-thalassemia major

The Turkish Journal of Pediatrics, 2020
Background and Objectives. Iron-induced cardiomyopathy remains the leading cause of mortality in β-thalassemia major patients. The T2* magnetic resonance imaging (MRI) technique is the gold standard for iron load detection, yet it is expensive and
Najib Advani, Ahmad Kautsar, Murti Andriastuti   +2 more
doaj   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review

Health Science Reports
Background and Aims Chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. This scoping review aimed to study
Abdulqadir J. Nashwan, Mohammad T. Abuawwad, Jaber H. Jaradat, Anas Ibraheem, Mohamed A. Yassin, Mohammad J. J. Taha   +5 more
doaj   +1 more source