Results 31 to 40 of about 1,317,788 (302)

Assessment of hepatic and cardiac iron overload in thalassemia patients by magnetic resonance imaging: Our experience in Alexandria University

The Egyptian Journal of Radiology and Nuclear Medicine, 2018
Aim of the study: The aim of this study was to assess the utility of MRI as a non-invasive technique for grading of the hepatic and cardiac iron overload in Thalassemia patients in a cohort of patients in Alexandria, Egypt.
Sara K. Elfawal, Doaa M. Emara, Ahmed A. Shehata   +2 more
doaj   +1 more source

Orchestrated regulation of iron trafficking proteins in the kidney during iron overload facilitates systemic iron retention. [PDF]

PLoS ONE, 2018
The exact route of iron through the kidney and its regulation during iron overload are not completely elucidated. Under physiologic conditions, non-transferrin and transferrin bound iron passes the glomerular filter and is reabsorbed through kidney ...
Avital Weiss, Lior Spektor, Lyora A Cohen, Lena Lifshitz, Inbar Magid Gold, De-Liang Zhang, Marianna Truman-Rosentsvit, Yael Leichtmann-Bardoogo, Abraham Nyska, Sefi Addadi, Tracey A Rouault, Esther G Meyron-Holtz   +11 more
doaj   +1 more source

Neuroprotective Role of α-Lipoic Acid in Iron-Overload-Mediated Toxicity and Inflammation in In Vitro and In Vivo Models

Antioxidants, 2022
Hemoglobin and iron overload is considered the major contributor to intracerebral hemorrhage (ICH)-induced brain injury. Accumulation of iron in the brain leads to microglia activation, inflammation and cell loss.
Giuseppe Carota, Alfio Distefano, Mariarita Spampinato, Cesarina Giallongo, Giuseppe Broggi, Lucia Longhitano, Giuseppe A. Palumbo, Rosalba Parenti, Rosario Caltabiano, Sebastiano Giallongo, Michelino Di Rosa, Riccardo Polosa, Vincenzo Bramanti, Nunzio Vicario, Giovanni Li Volti, Daniele Tibullo   +15 more
doaj   +1 more source

Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload

Molecular Metabolism, 2021
Objective The molecular pathogenesis of late complications associated with type 2 diabetes mellitus (T2DM) is not yet fully understood. While high glucose levels indicated by increased HbA1c only poorly explain disease progression and late complications,
S. Altamura, K. Müdder, A. Schlotterer, T. Fleming, Elena Heidenreich, Ruiyue Qiu, H. Hammes, P. Nawroth, M. Muckenthaler   +8 more
semanticscholar   +1 more source

Impact of iron overload on interleukin-10 levels, biochemical parameters and oxidative stress in patients with sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia, 2013
OBJECTIVE: The aim of this study was to evaluate the impact of iron overload on the profile of interleukin-10 levels, biochemical parameters and oxidative stress in sickle cell anemia patients.
Maritza Cavalcante Barbosa, Talyta Ellen Jesus dos Santos, Geane Félix de Souza, Lívia Coêlho de Assis, Max Victor Carioca Freitas, Romélia Pinheiro Gonçalves   +5 more
doaj   +3 more sources

Is iron overload associated with worse outcomes in patients with chronic liver disease undergoing liver transplantation?

Revista de Investigación Clínica
Background: Iron overload is frequent in patients with chronic liver disease, associated with shorter survival after liver transplantation in patients with hereditary hemochromatosis.
Sergio Rodriguez-Rodriguez, Antonio Olivas-Martínez, Jesus Delgado-de la Mora, Braulio Martinez-Benitez, Ignacio García-Juarez, Roberta Demichelis-Gómez   +5 more
doaj   +1 more source

Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine

Journal of Toxicology, 2018
Objective. The aim of our study is to compare the role of the new natural alternative (Quercetin) with the current iron-chelation therapy (Deferoxamine (DFO)) in the effect of iron overload on small intestinal tissues and to investigate the possible ...
Arwa A. El-Sheikh, Shimaa Hamed Ameen, Samaa Salah AbdEl-Fatah   +2 more
doaj   +1 more source

Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis

American Journal of Transplantation, 2020
Hepatic ischemia‐reperfusion (I/R) injury is a major problem in liver transplantation (LT). Although hepatocyte cell death is the initial event in hepatic I/R injury, the underlying mechanism remains unclear.
N. Yamada, T. Karasawa, T. Wakiya, Ai Sadatomo, Homare Ito, Ryouta Kamata, Sachiko Watanabe, T. Komada, Hiroaki Kimura, Y. Sanada, Y. Sakuma, K. Mizuta, N. Ohno, N. Sata, Masafumi Takahashi   +14 more
semanticscholar   +1 more source

Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice

Journal of Advanced Research
Introduction: Iron overload disrupts gut microbiota and induces ferroptosis, contributing to colitis. However, whether gut microbiota directly drives iron overload-induced colitis and its underlying mechanism remain unclear.
Ke Gu, Aimin Wu, Chen Liu, Bing Yu, Jun He, Xin Lai, Junzhou Chen, Yuheng Luo, Hui Yan, Ping Zheng, Junqiu Luo, Junning Pu, Quyuan Wang, Huifen Wang, Daiwen Chen   +14 more
doaj   +1 more source

Curcumin Attenuates Iron Accumulation and Oxidative Stress in the Liver and Spleen of Chronic Iron-Overloaded Rats. [PDF]

PLoS ONE, 2015
Iron overload is now recognized as a health problem in industrialized countries, as excessive iron is highly toxic for liver and spleen. The potential use of curcumin as an iron chelator has not been clearly identified experimentally in iron overload ...
Farid A Badria, Ahmed S Ibrahim, Adel F Badria, Ahmed A Elmarakby   +3 more
doaj   +1 more source