Results 101 to 110 of about 16,503 (251)

Isatin: Role in stress and anxiety

Stress, 2005
(Indoledione 2,3) isatin is an endogenous indole found both in mammalian brain and peripheral tissues. Isatin concentration in blood can exceed 1 microM and tissue concentrations vary from < 0.1 to 10 microM. Its level in the brain and periphery is increased by stress. Isatin has a wide spectrum of behavioural and metabolic effects. It is anxiogenic at
Vivette Glover, Natalia Igosheva, Alexei Medvedev, Michèle Crumeyrolle-Arias   +3 more
openaire   +3 more sources

Molecular docking and synthesis of N-alkyl-isatin-3-imino aromatic amine derivatives and their antileishmanial and cytotoxic activities

Research in Pharmaceutical Sciences
Background and purpose: Isatin derivatives have excited attention due to their biological attractions, especially, anticancer properties. Isatin analogs such as semaxanib and sunitinib were exposed to tyrosine kinase inhibitory properties.
Farshid Hassanzadeh, Seyed Hossein Hejazi, Elham Jafari, Atefeh Mohammadi fard, Hojjat Sadeghi-aliabadi   +4 more
doaj   +1 more source

THE SYNTHESIS OF NEW SPIROLACTONES FROM SUBSTITUTED ISATINS [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2015
Interaction of N-ethyl isatin 3 with dimethyl acetylenedicarboxylate in the presence triphenylphosphine has led to good selectivity of methyl 1'-ethyl-4-methoxy-2',5-dioxo-5H-spiro[furan-2,3'-indoline]-3-carboxylate 4 formation.
Natalia Sucman, Vsevolod Pogrebnoi, Mykola Obushak, Elena Melnic, Victor Kravtsov, Fliur Macaev   +5 more
doaj  

Daganatos sejtek rezisztenciáját gátló vegyületek fejlesztése = Development of compounds targeting multidrug resistant cancer [PDF]

, 2009
A korszerű daganatellenes terápia jelentős sikerei ellenére a kemoterápiával szemben fellépő rezisztencia (multidrog rezisztencia, MDR) továbbra is megoldásra váró klinikai kihívás.
Szakács, Gergely
core  

Evaluation of the Antibacterial Activity of Isatin against Campylobacter jejuni and Campylobacter coli Strains

Applied Microbiology
Antibiotic resistance, particularly against fluoroquinolones and macrolides, has emerged globally among thermophilic Campylobacters (Campylobacter jejuni and Campylobacter coli), giving rise to concerns about the efficacy of antibiotic treatment of these
Claudia B. Barroso, Liliane M. Seki, Wagner T. C. Esteves, Michele C. Nascimento, Aurea Echevarria   +4 more
doaj   +1 more source

The Effect of Neurotoxin MPTP and Neuroprotector Isatin on the Profile of Ubiquitinated Brain Mitochondrial Proteins

Cells, 2018
Mitochondria are a crucial target for the actions of neurotoxins, causing symptoms of Parkinson’s disease in various experimental animal models, and also neuroprotectors.
Olga Buneeva, Arthur Kopylov, Inga Kapitsa, Elena Ivanova, Victor Zgoda, Alexei Medvedev   +5 more
doaj   +1 more source

Visualising substrate-fingermark interactions: Solid-state NMR spectroscopy of amino acid reagent development on cellulose substrates [PDF]

, 2015
© 2015 Elsevier Ireland Ltd. Most spectroscopic studies of the reaction products formed by ninhydrin, 1,2-indanedione-zinc (Ind-Zn) and 1,8-diazafluoren-9-one (DFO) when reacted with amino acids or latent fingermarks on paper substrates are focused on ...
Lennard, C, Roux, C, Shimmon, R, Spindler, X   +3 more
core   +1 more source

Room Temperature, Open-Flask C–P Bond-Formation on Water under Catalyst-Free Conditions

SynOpen, 2018
A catalyst-free C–P bond-formation in an open flask at room temperature between isatin derivatives and phosphorus surrogates on water is described. Isatin derivatives possessing different substitutes underwent C–P coupling reaction with a variety of ...
Rakhee Choudhary, Rekha Bai, Pratibha Singh, Mahesh C. Sharma, Satpal Singh Badsara   +4 more
doaj   +1 more source

Synthesis and evaluation of anticonvulsant activity of (Z)-4-(2-oxoindolin-3-ylideneamino)-N-phenylbenzamide derivatives in mice

Research in Pharmaceutical Sciences, 2018
Due to resistance of some epileptic patients to the current medications and the general incidence of severe side effects of these drugs, development and discovery of novel antiepileptic drugs is crucial.
Marzieh Rahmani Khajouei, Ahmad Mohammadi-Farani, Aref Moradi, Alireza Aliabadi   +3 more
doaj   +1 more source

Synthesis of 4-Amino-4,5-dihydro-1H-1,2,4-triazole-5-ones and their Isatin-3-imine Derivatives

Molecules, 2005
Iminoester hydrochlorides 1 have been synthesized. These compounds werethen converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new seriesof substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared.Finally a set ...
Bahittin Kahveci
doaj   +1 more source