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ChemInform Abstract: New Isatin Derivatives
ChemInform, 2010AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
E. G. Mesropyan, A. A. Avetisyan
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Synthesis of Isatin and 5-Bromoisatin Derivatives
Russian Journal of Organic Chemistry, 2001New N-derivatives of isatin were synthesized by treating ethyl chloroacetate, N-(2-chloroethyl)morpholine, and 1,4-di(chloromethyl)benzene with isatin sodium salt. N-Derivatives of isatin and 5-bromoisatin were also prepared by Mannich reaction.
E. G. Mesropyan +4 more
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Synthesis, Fluorescence, and Bioactivity of Novel Isatin Derivatives
The Journal of Physical Chemistry BThe isatin group is widespread in nature and is considered to be a privileged building block for drug discovery. In order to develop novel SHP1 inhibitors with fluorescent properties as tools for SHP1 biology research, this work designed and synthesized a series of isatin derivatives.
Yi-Xin Dong +9 more
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Isatin Derivatives with Potential Antitubercular Activities
Journal of Heterocyclic Chemistry, 2018Tuberculosis is a life‐threatening chronic infectious disease, which primarily affects the lungs but can spread to other vital organs. The re‐emergence and wide spread of new virulent forms of Mycobacterium tuberculosis that are resistant to some or all first and second line antitubercular agents has reached an alarming level in recent decades.
Dan Jiang +5 more
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Isatin Derivatives: A Frontier in Antimicrobial Agents
Letters in Organic ChemistryAbstract: Microbial infection is one of the major concerns for human health in the modern era. Condition is further worsening due to the development of resistance by the microbe against the available drugs. This problem can be overcome by synthesizing novel antimicrobial agents. Isatin is a promising moiety possessing antimicrobial activity.
Shareef Shaik +4 more
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In vitro cytotoxicity evaluation of some substituted isatin derivatives
Bioorganic & Medicinal Chemistry, 2007A range of substituted 1H-indole-2,3-diones (isatins) were synthesized using standard procedures and their cytotoxicity evaluated against the human monocyte-like histiocytic lymphoma (U937) cell line in vitro. SAR studies identified C(5), C(6), and C(7) substitution greatly enhanced activity with some di- and tri-halogenated isatins giving IC(50 ...
Benkendorff, Kirsten +5 more
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Ylide mediated carbonyl homologations for the preparation of isatin derivatives
Org. Biomol. Chem., 2014An exceptionally mild method for the preparation of isatin derivatives has been developed using a sulfur ylide mediated carbonyl homologation sequence starting from anthranilic acid precursors. This method proceeds at ambient temperature via a sulfur ylide intermediate without the need for protection of the amine or chromatographic isolation of the ...
Christina T, Lollar +3 more
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