Results 181 to 190 of about 7,252 (218)

Isatin Derivatives with Potential Antitubercular Activities

Journal of Heterocyclic Chemistry, 2018
Tuberculosis is a life‐threatening chronic infectious disease, which primarily affects the lungs but can spread to other vital organs. The re‐emergence and wide spread of new virulent forms of Mycobacterium tuberculosis that are resistant to some or all first and second line antitubercular agents has reached an alarming level in recent decades.
Dan Jiang, Gang‐Qiang Wang, Xiaofeng Liu, Zhenbin Zhang, Lian‐Shun Feng, Ming‐Liang Liu   +5 more
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VASODILATORY ACTIVITY OF NOVEL CARBAMATE DERIVATIVES OF ISATIN

Clinical and Experimental Pharmacology and Physiology, 2008
SUMMARY Isatin (1H‐indole‐2,3 dione) is an endogenous compound that may act as a physiological regulator of muscle contraction by reducing cGMP production by inhibition of guanylyl cyclase (GC) activity. Intracellular cGMP levels can regulate the contractile response of smooth muscle.
Patricia A, Maroñas, Roberto T, Sudo, Marilza B, Corrêa, Angelo C, Pinto, Simon J, Garden, Margarete M, Trachez, Gisele, Zapata-Sudo   +6 more
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Microwave‐Assisted Synthesis of Quinoline Derivatives from Isatin

Synthetic Communications, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
E. Sayed H. El Ashry, El Sayed Ramadan, Hamida Abdel Hamid, Mohamed Hagar   +3 more
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Organocatalytic Enantioselective Peroxidation of Ketimines Derived from Isatins

Organic Letters, 2015
The first catalytic enantioselective addition of hydroperoxides to ketimines derived from isatins has been developed. Excellent yields and enantioselectivities were observed for the reaction of various ketimines with peroxides using a cinchona alkaloid sulfonamide catalyst.
Shuichi, Nakamura, Shun, Takahashi
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Synthesis, Fluorescence, and Bioactivity of Novel Isatin Derivatives

The Journal of Physical Chemistry B
The isatin group is widespread in nature and is considered to be a privileged building block for drug discovery. In order to develop novel SHP1 inhibitors with fluorescent properties as tools for SHP1 biology research, this work designed and synthesized a series of isatin derivatives.
Yi-Xin Dong, Li-Xin Gao, Qing Cao, Zi-Tong Cao, Su-Ya Gan, Jia Li, Yun-Long Zhu, Yu-Bo Zhou, Chun Zhang, Wen-Long Wang   +9 more
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Synthesis of Isatin and 5-Bromoisatin Derivatives

Russian Journal of Organic Chemistry, 2001
New N-derivatives of isatin were synthesized by treating ethyl chloroacetate, N-(2-chloroethyl)morpholine, and 1,4-di(chloromethyl)benzene with isatin sodium salt. N-Derivatives of isatin and 5-bromoisatin were also prepared by Mannich reaction.
E. G. Mesropyan, G. B. Ambartsumyan, A. A. Avetisyan, M. G. Sarkisyan, G. S. Amazaspyan   +4 more
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Michael Addition between Isatin and Acrylate Derivatives

Letters in Organic Chemistry, 2011
A simple and efficient Michael addition of isatin to acrylate in the presence of KOH was described. Methyl beta-(2,3-dioxoindolin-1-yl) propanoate was synthesized firstly by the addition of isatin to methyl acrylate in a feasible approach using 10% KOH as catalyst in DMF with the highest yield of 72.5% under the optimized conditions.
Gang Chen, Ying Tang, Jie Zhang, Ya Wu, Xiao-Jiang Hao, Shu-Zhen Mu   +5 more
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In vitro cytotoxicity evaluation of some substituted isatin derivatives

Bioorganic & Medicinal Chemistry, 2007
A range of substituted 1H-indole-2,3-diones (isatins) were synthesized using standard procedures and their cytotoxicity evaluated against the human monocyte-like histiocytic lymphoma (U937) cell line in vitro. SAR studies identified C(5), C(6), and C(7) substitution greatly enhanced activity with some di- and tri-halogenated isatins giving IC(50 ...
Benkendorff, Kirsten, Vine, Kara L, Locke, Julie M, Ranson, Marie, Pyne, Stephen G, Bremner, John B   +5 more
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Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors

Bioorganic & Medicinal Chemistry Letters, 2009
The isatin core structure was found to be a novel chemical scaffold in transthyretin (TTR) fibrillogenesis inhibitor design. Among the series of isatin analogues prepared and tested, the nitro compound 1,3-dihydro-3-[(4-nitrophenyl)imino]-2H-indol-2-one (2r) is as potent as triiodophenol, which is one of the most active known TTR inhibitors.
Asensio, González, Josefina, Quirante, Joan, Nieto, Maria Rosário, Almeida, Maria Joao, Saraiva, Antoni, Planas, Gemma, Arsequell, Gregorio, Valencia   +7 more
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Synthesis, anti‐HIV and Antitubercular Activities of Isatin Derivatives.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
D, Sriram, P, Yogeeswari, K, Meena
openaire   +2 more sources