Results 181 to 190 of about 1,535,483 (232)

Synthesis, molecular docking, and biological evaluation of novel 1,2,4‐triazole‐isatin derivatives as potential Mycobacterium tuberculosis shikimate kinase inhibitors

Chemical Biology and Drug Design, 2022
The issue of emerging resistance to antitubercular drugs has created a formidable barrier in the effective prevention and cure of tuberculosis globally. In an effort to search for new antimycobacterial agents, possibly comprising new pharmacophore, novel
Vedika Dadlani, Heta Chhabhaiya, R. Somani, P. Tripathi   +3 more
semanticscholar   +1 more source

Synthesis and Phytotoxic Evaluation of Isatin Derivatives Supported by 3D-QSAR Study.

Journal of Agricultural and Food Chemistry, 2022
Concerned about weed infestation, a major threat to food production and herbicide resistance that interferes in the mechanism of action of the main herbicides, we have synthesized eight isatin derivatives using the "Click Chemistry" approach through ...
Pedro Alves Bezerra Morais, K. Britto, Evandro Messias, Peterson de Andrade, E. Werner, A. Costa, Valdemar Lacerda, C. J. Pinheiro, Heberth de Paula, W. Borges   +9 more
semanticscholar   +1 more source

New isatin derivatives

Russian Journal of Organic Chemistry, 2009
The review compiles published data on the synthesis and biological action of new isatin derivatives containing in their composition additional oxygen, nitrogen, or sulfur heterocycles.
E. G. Mesropyan, A. A. Avetisyan
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Electrochemical characterization of isatin-thiosemicarbazone derivatives

Journal of Chemical Sciences, 2021
Herein, we have notably described the electrochemical behavior of four isatin-thiosemicarbazone derivatives. In this regard, cyclic voltammograms of isatin-3-thiosemicarbazone (ITSC), isatin-3-(N4-benzylthiosemicarbazone) (ITSC-Ph), 1-(5-nitro-2-oxoindolin-3-ylidene)thiosemicarbazide (NO2-ITSC) and 1-(5-nitro-2-oxoindolin-3-ylidene)-4 ...
Juliano da Rosa Justim, Lucas Martins Correa Bohs, Bianca Barreto Martins, Katlen Christian Tribuzy Bandeira, Ana Paula Lopes de Melo, Vanessa Carratu Gervini, Leandro Bresolin, Marcelo Godoi, Carlos Roberto de Menezes Peixoto   +8 more
openaire   +1 more source

New isatin derivatives with antioxidant activity

European Journal of Medicinal Chemistry, 2010
The reaction between isatin and 2,5-dimethoxyaniline is described. The main product was identified as 3,3-bis(4-amino-2,5-dimethoxyphenyl)-1,3-dihydroindol-2-one. The antioxidant activity of the compounds isolated was evaluated with two methods. Three published antitumor E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones entered the same tests to
ANDREANI, ALDO, BURNELLI, SILVIA, GRANAIOLA, MASSIMILIANO, LEONI, ALBERTO, LOCATELLI, ALESSANDRA, MORIGI, RITA, RAMBALDI, MIRELLA, VAROLI, LUCILLA, CREMONINI, MAURO ANDREA, PLACUCCI, GIUSEPPE, CERVELLATI, RINALDO, GRECO, EMANUELA   +11 more
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Synthesis of New Aromatic Isatin Derivatives

Russian Journal of Organic Chemistry, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
E. G. Mesropyan, G. B. Ambartsumyan, A. A. Avetisyan, M. G. Sargsyan, A. S. Galstyan   +4 more
openaire   +1 more source

VASODILATORY ACTIVITY OF NOVEL CARBAMATE DERIVATIVES OF ISATIN

Clinical and Experimental Pharmacology and Physiology, 2008
SUMMARY Isatin (1H‐indole‐2,3 dione) is an endogenous compound that may act as a physiological regulator of muscle contraction by reducing cGMP production by inhibition of guanylyl cyclase (GC) activity. Intracellular cGMP levels can regulate the contractile response of smooth muscle.
Patricia A, Maroñas, Roberto T, Sudo, Marilza B, Corrêa, Angelo C, Pinto, Simon J, Garden, Margarete M, Trachez, Gisele, Zapata-Sudo   +6 more
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Structural improvement of new thiazolyl-isatin derivatives produces potent and selective trypanocidal and leishmanicidal compounds.

Chemico-Biological Interactions, 2021
Neglected diseases are a group of transmissible diseases that occur mostly in countries in tropical climates. Among this group, Chagas disease and leishmaniasis stand out, considered threats to global health.
Luiz Alberto Barros Freitas, Aline Caroline da Silva Santos, Gedália de Cássia Silva, Franciely Nayara do Nascimento Albuquerque, E. Silva, Carlos Alberto de Simone, Valeria R Alves Pereira, L. Alves, F. Brayner, A. Lima Leite, Paulo André Teixeira de Moraes Gomes   +10 more
semanticscholar   +1 more source

New isatin derivatives: synthesis and reactions

Synthetic Metals, 1990
Abstract The synthesis of new 5-substituted isatins with 2-thienyl, 3-thienyl, 2,2′-bithien-5-yl and phenyl substituents is described. The compounds were prepared via the palladium-catalysed cross-coupling reaction of 5-bromoisatin with 2-thiophene, 3-thiophene, 2,2′-bithien-5-yl and benzene boronic acids, respectively.
Francisco Martinez, Herbert Naarmann
openaire   +1 more source

Synthesis of Isatin and 5-Bromoisatin Derivatives

Russian Journal of Organic Chemistry, 2001
New N-derivatives of isatin were synthesized by treating ethyl chloroacetate, N-(2-chloroethyl)morpholine, and 1,4-di(chloromethyl)benzene with isatin sodium salt. N-Derivatives of isatin and 5-bromoisatin were also prepared by Mannich reaction.
E. G. Mesropyan, G. B. Ambartsumyan, A. A. Avetisyan, M. G. Sarkisyan, G. S. Amazaspyan   +4 more
openaire   +1 more source