Results 251 to 260 of about 469,171 (282)

Trimetazidine in the Prevention of Tissue Ischemic Conditions

Angiology, 2018
Trimetazidine (TMZ) is a metabolic agent with significant anti-ischemic properties. By inhibiting the terminal enzyme in the β-oxidation pathway, it shifts the energy substrate metabolism, enhancing glucose metabolism. Thus, it maintains the required energy production with less oxygen consumption, an effect necessary in cases of myocardi. Trimetazidine
Manolis S. Kallistratos, Leonidas E. Poulimenos, Sofia Giannitsi, Pavlos Tsinivizov, Athanasios J. Manolis   +4 more
openaire   +2 more sources

Pre-Emptive Conditioning of the Ischemic Heart

Cardiovascular & Hematological Agents in Medicinal Chemistry, 2008
Ischemic heart disease remains one of the most frequent causes of morbidity and mortality worldwide. Although the prognosis of myocardial ischemia has been dramatically improved by the techniques of early reperfusion, the prevention of irreversible ischemic damage remains a critical aspect of the treatment. An appealing novel therapeutic avenue for the
Joseph M, Vitale, Hongyu, Qiu, Christophe, Depre   +2 more
openaire   +2 more sources

Ischemic Conditioning: Implications for Emergency Medicine

Annals of Emergency Medicine, 2016
Ischemic conditioning refers to the ability of brief episodes of controlled hypoperfusion around the time of an acute ischemic event to protect the target organ from reperfusion injury. A considerable body of literature suggests that interventions as simple and safe as repetitively inflating a blood pressure cuff could reduce the size and long-term ...
Kenneth, Frumkin, Adam S, Bloom
openaire   +2 more sources

The therapeutic potential of ischemic conditioning: an update

Nature Reviews Cardiology, 2011
Novel approaches are required to improve clinical outcomes in patients with coronary heart disease (CHD). Ischemic conditioning--the practice of applying brief episodes of nonlethal ischemia and reperfusion to confer protection against a sustained episode of lethal ischemia and reperfusion injury--is one potential therapeutic strategy. Importantly, the
Derek J, Hausenloy, Derek M, Yellon
openaire   +2 more sources

Remote Ischemic Conditioning in Stroke Recovery

Physical Medicine and Rehabilitation Clinics of North America
Remote ischemic conditioning (RIC) is a therapeutic strategy to protect a vital organ like the brain from ischemic injury through brief and repeat cycles of ischemia and reperfusion in remote body parts such as arm or leg. RIC has been applied in different aspects of the stroke field and has shown promise. This narrative review will provide an overview
Chih-Hao, Chen, Aravind, Ganesh
openaire   +2 more sources

Remote Ischemic Conditioning

JAMA, 2022
David C, Hess, Rolf A, Blauenfeldt, Grethe, Andersen   +2 more
openaire   +2 more sources

Clinical Trials of Ischemic Conditioning

2012
Stroke is one of the leading causes of mortality and the leading cause of disability in the United States and is a prevalent and devastating pathological entity worldwide. Alongside primary prevention, acute pharmacological or mechanical intercessions, maximization of collateral blood flow, and neuroprotection, the innovative idea of inducing an ...
Michael Katsnelson, Sebastian Koch
openaire   +1 more source

Remote ischemic conditioning — The unknown

International Journal of Cardiology, 2011
Ronit, Lavi, Shahar, Lavi
openaire   +2 more sources

Autophagy and post-ischemic conditioning in retinal ischemia

Autophagy, 2021
Leslie Aldrich, Biji Mathew
exaly  

Quantitative Proteomic Analysis of Plasma after Remote Ischemic Conditioning in a Rhesus Monkey Ischemic Stroke Model

Biomolecules, 2021
Yuchuan Ding, Xunming Ji, Ran Meng
exaly