Results 11 to 20 of about 11,054 (137)

Non-ischemic myocardial preconditioning

Molecular and Cellular Biochemistry, 1998
The reduction of infarct size produced by brief ischemic episodes prior to a sustained occlusion of a coronary artery, called ischemic preconditioning, is a well known phenomenon that occurs in several species, but its mechanism is still under investigation.
Domenech Lira, Raúl, Macho Fisher, Pilar   +1 more
openaire   +3 more sources

Effects of naloxone on myocardial ischemic preconditioning in humans

Journal of the American College of Cardiology, 1999
We attempted to establish whether naloxone, an opioid receptor antagonist, abolishes the adaptation to ischemia observed in humans during coronary angioplasty after repeated balloon inflations.Experimental studies indicate that myocardial opioid receptors are involved in ischemic preconditioning.Twenty patients undergoing angioplasty for an isolated ...
Tomai F, Crea F, Gaspardone A, Versaci F, Ghini AS, FERRI, CLAUDIO, DESIDERI, GIOVAMBATTISTA, Chiariello L, Gioffré PA   +8 more
openaire   +3 more sources

The tole of ischemic preconditioning in acute myocardial infarction

Medicinski pregled, 2005
Introduction Ischemic preconditioning is a phenomenon in which brief episodes of ischemia and reperfusion increase myocardial tolerance and substantially reduce the infarction size. Case report Two patients with acute left anterior descending artery occlusion received fibrinolytic therapy within 6 hours of symptom onset, but nevertheless developed ...
Andelka, Ristić, Milorad, Damjanović, Branislav, Baskot, Sasa, Rafaelovski   +3 more
openaire   +3 more sources

Impact of hypoglycemic agents on myocardial ischemic preconditioning

World Journal of Diabetes, 2014
Murry et al in 1986 discovered the intrinsic mechanism of profound protection called ischemic preconditioning. The complex cellular signaling cascades underlying this phenomenon remain controversial and are only partially understood. However, evidence suggests that adenosine, released during the initial ischemic insult, activates a variety of G protein-
Rosa Maria, Rahmi Garcia, Paulo Cury, Rezende, Whady, Hueb   +2 more
openaire   +2 more sources

Role of microtubules in ischemic preconditioning against myocardial infarction [PDF]

Cardiovascular Research, 2004
The role of microtubules in ischemic preconditioning (PC) was investigated in isolated perfused rabbit hearts.Myocardial infarction was induced by 30-min global ischemia and 2-h reperfusion, and infarct size was expressed as a percentage of the left ventricle (%IS/LV).
Yuichi, Nakamura, Tetsuji, Miura, Atsushi, Nakano, Yoshihiko, Ichikawa, Toshiyuki, Yano, Hironori, Kobayashi, Yoshihiro, Ikeda, Takayuki, Miki, Kazuaki, Shimamoto   +8 more
openaire   +2 more sources

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Unveiling the Microvasculature: The Index of Microcirculatory Resistance and Its Expanding Role in Cardiovascular Care

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Index of microcirculatory resistance (IMR) is a cutting‐edge, wire‐based tool that advances the capability assessment of coronary microvascular function. By utilizing distal coronary pressure and mean transit time under maximal hyperemia, IMR delivers consistent, reproducible insights into the microvasculature's dynamic health.
Joanna Sohn, Matthew A. Soderstrom, Ariana Ramirez, John‐Henry Dean, Raj Shah, Debanshu Roy, Kenneth Stone, Ariel Vinas, Bryan Ramsey, Charles Lin, Robert Chilton   +10 more
wiley   +1 more source

A practical approach to remote ischemic preconditioning and ischemic preconditioning against myocardial ischemia/reperfusion injury

Journal of Biological Methods, 2016
Although urgently needed in clinical practice, a cardioprotective therapeutic approach against myocardial ischemia/reperfusion injury remains to be established. Remote ischemic preconditioning (rIPC) and ischemic preconditioning (IPC) represent promising tools comprising three entities: the generation of a protective signal, the transfer of the signal ...
Totzeck, Matthias, Hendgen-Cotta, Ulrike B., French, Brent A., Rassaf, Tienush   +3 more
openaire   +3 more sources

Cardiac surveillance in immune checkpoint inhibitor therapy: Insights from the Essen Cardio‐oncology Registry

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, offering improvements in survival across various malignancies. However, their toxicities pose a major challenge for cardio‐oncology units. Despite their growing importance, data on effectiveness of such specialized units in mitigating ICI‐associated ...
Elias Haj‐Yehia, Lisa Zimmer, Lena Lampe, Dimitra Vlachopoulou, Matthias Totzeck, Tienush Rassaf, Raluca I. Mincu   +6 more
wiley   +1 more source