Results 11 to 20 of about 11,601 (142)

Clinical Application of Ischemic Preconditioning in the Elderly

Dose-Response, 2010
A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning).
Pasquale Abete, Francesco Cacciatore, Gianluca Testa, David Della-Morte, Gianluigi Galizia, Nicola Ferrara, Franco Rengo   +6 more
doaj   +1 more source

Myocardial ischemic preconditioning in a porcine model leads to rapid changes in cardiac extracellular vesicle messenger RNA content

International Journal of Cardiology: Heart & Vasculature, 2015
Background: Extracellular vesicles (EVs) are thought to exert protective effects after ischemic and remote ischemic preconditioning. It is not well understood which EV content factors are most relevant for protective effects. We hypothesize that ischemic
Kristina Svennerholm, Pouria Rodsand, Urban Hellman, Marie Lundholm, Anders Waldenström, Björn Biber, Gunnar Ronquist, Michael Haney   +7 more
doaj   +1 more source

DNA Content in Extracellular Vesicles Isolated from Porcine Coronary Venous Blood Directly after Myocardial Ischemic Preconditioning. [PDF]

PLoS ONE, 2016
BACKGROUND:Extracellular vesicles (EV) are nano-sized membranous structures released from most cells. They have the capacity to carry bioactive molecules and gene expression signals between cells, thus mediating intercellular communication.
Kristina Svennerholm, Pouria Rodsand, Urban Hellman, Anders Waldenström, Marie Lundholm, Dag Ahrén, Björn Biber, Gunnar Ronquist, Michael Haney   +8 more
doaj   +1 more source

Effects of ischemia and omeprazole preconditioning on functional recovery of isolated rat heart

Brazilian Journal of Cardiovascular Surgery, 2015
Objective:The aim of this study was to compare protective effects of ischemic and potential protective effects of pharmacological preconditioning with omeprazole on isolated rat heart subjected to ischemia/reperfusion.Methods:The hearts of male Wistar ...
Nevena Jeremic, Anica Petkovic, Ivan Srejovic, Vladimir Zivkovic, Dragan Djuric, Vladimir Jakovljevic   +5 more
doaj   +1 more source

Is Local Nitric Oxide Availability Responsible for Myocardial Salvage after Remote Preconditioning?

Arquivos Brasileiros de Cardiologia, 2016
Background: Remote ischemic preconditioning (RIPC) represents an attractive therapy for myocardial protection, particularly when ischemic events can be anticipated. Although several hypothetic mechanisms have been proposed, no definite molecular pathways
Esbeidira Aranet Arroyo-Martínez, Alejandra Meaney, Gabriela Gutiérrez-Salmeán, Juan Miguel Rivera-Capello, Vidal González-Coronado, Alejandro Alcocer-Chauvet, Genaro Castillo, Nayelli Nájera, Guillermo Ceballos, Eduardo Meaney   +9 more
doaj   +1 more source

The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention

Advances in Interventional Cardiology, 2017
Introduction : Myocardial injury after percutaneous coronary intervention (PCI) occurs in approximately 30% of procedures, and is related to worse prognosis.
Mustafa A. Yılmaztepe, Gökay Taylan, Meryem Aktoz, Hanefi Y. Gürlertop, Yüksel Aksoy, Fatih Özçelik, Kenan Yalta, Galip Ekuklu   +7 more
doaj   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Cardiac Remote Conditioning and Clinical Relevance: All Together Now!

Engineering, 2015
Acute myocardial infarction (AMI) is the leading cause of death and disability worldwide. Timely reperfusion is the standard of care and results in decreased infarct size, improving patient survival and prognosis.
Kristin Luther, Yang Song, Yang Wang, Xiaoping Ren, W. Keith Jones   +4 more
doaj   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source