Results 41 to 50 of about 11,601 (142)

The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease

British Journal of Pharmacology, Volume 183, Issue 19, Page 5732-5751, October 2026.
Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam, James Harris, Jürgen Bernhagen, Antony Vinh, Katrina M. Mirabito Colafella   +4 more
wiley   +1 more source

Pré-condicionamento isquémico remoto do miocárdio: dos mecanismos fisiopatológicos à aplicação na prática clínica

Revista Portuguesa de Cardiologia, 2013
Resumo: Curtos períodos de isquemia do miocárdio seguida de reperfusão induzem um mecanismo de cardioproteção quando este é depois submetido a um período de isquemia prolongada, um fenómeno designado pré-condicionamento isquémico.Além da sua aplicação ...
José F. Costa, Ricardo Fontes-Carvalho, Adelino F. Leite-Moreira   +2 more
doaj   +1 more source

Engineering CAR‐Macrophages With Advanced Delivery Systems for Tissue Repair

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This review highlights how engineered macrophages equipped with chimeric antigen receptors (CAR) guide tissue repair by recognizing disease‐related targets, clearing harmful cells, and reshaping local immune environments. It summarizes macrophage biology, CAR design, delivery platforms, and functionalization strategies, and discusses emerging ...
Yixin Zhang, Jintian Yu, Liang Yuan, Ziliang Fu, Yiming Yao, Lingna Chen, Shixiong Chen, Aikemu Ainiwaer, Xiaolin Cui   +8 more
wiley   +1 more source

myocardial responses to ischemia

Терапевтический архив, 2010
The paper details the types of a myocardial response to impaired blood flow, such as myocardial stunning, hibernation, ischemic preconditioning, warm-up phenomenon, ischemic postconditoning, remodeling, and infarction.
Viktor Gennad'evich Borisenko, Elena Aleksandrovna Gubareva, Azamat Khalidovich Kade, V G Borisenko, E A Gubareva, A Kh Kade   +5 more
doaj  

Plasma exosomal miR‐339‐3p promotes myocardial remodeling in chronic heart failure by regulating USP25‐mediated DDX58 deubiquitination

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
In the patients of chronic heart failure (HF), miR‐339‐3p derived from plasma exosomes can target ubiquitin‐specific protease 25, inhibiting its K48‐linked deubiquitination modification of DDX58, leading to increased ubiquitination and degradation of DDX58.
Guoqiang Jing, Ting Xu, Yuhong Ma
wiley   +1 more source

Exercise‐Induced Myonectin Protects Against Cerebral Ischemia–Reperfusion Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Exercise‐induced myonectin protects against cerebral ischemia–reperfusion injury. Myonectin knockout abolishes exercise benefits, whereas recombinant administration reduces cerebral infarct size. Mechanistically, myonectin activates PI3K/AKT/mTOR signaling, thereby suppressing excessive neuronal autophagy and microglial‐driven neuroinflammation ...
Jing Zhang, Shengle Chen, Jingyu Liu, Xin Qi, Xiaoming Zhang, Peng Lin, Dezhang Huang, Jing Li   +7 more
wiley   +1 more source

Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation

iNew Medicine, Volume 2, Issue 3, September 2026.
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng, Wenhui Zhao, Min Wang, Xianwen Wang   +3 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Adenosine Preconditioning versus Ischemic Preconditioning in Patients undergoing Off-Pump Coronary Artery Bypass (OPCAB)

Journal of Tehran University Heart Center, 2015
Background: During off-pump coronary artery bypass (OPCAB), the heart is subjected to ischemic and reperfusion injury. Preconditioning is a mechanism that permits the heart to tolerate myocardial ischemia. The aim of this study was to compare the effects
SeyedKhalil Forouzannia, MohammadHassan Abdollahi, SeyedJalil Mirhosseini, Mehdi Hadadzadeh, Rouholla Zarepur, Ehsan Zarepur, Omid Beiki, Mohammadtaghi Sarebanhassanabadi   +7 more
doaj  

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source