Results 31 to 40 of about 11,601 (142)

Improved resistance to ischemia and reperfusion, but impaired protection by ischemic preconditioning in patients with type 1 diabetes mellitus: a pilot study

Cardiovascular Diabetology, 2012
Background In patients with type 1 diabetes mellitus (T1DM), cardiovascular events are more common, and the outcome following a myocardial infarction is worse than in nondiabetic subjects.
Engbersen Richard, Riksen Niels P, Mol Marc J, Bravenboer Bert, Boerman Otto C, Meijer Patrick, Oyen Wim JG, Tack Cees, Rongen Gerard A, Smits Paul   +9 more
doaj   +1 more source

S14G‐humanin attenuates renal ischaemia–reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats

Experimental Physiology, EarlyView.
Abstract Renal ischaemia–reperfusion (I/R) injury leads to acute tubular necrosis and renal failure, triggering pathological mechanisms including inflammation, reactive oxygen species generation, apoptosis and mitochondrial dysfunction. The mitochondrial peptide humanin (HN), known to possess anti‐apoptotic and anti‐inflammatory properties, has been ...
Leyla Abueid, Ahmet Faruk Torun, Ezgi Golal, Nuray Acar, Filiz Basrali   +4 more
wiley   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source

A Comparative Study: Cardioprotective Effects of High-Intensity Interval Training Versus Ischaemic Preconditioning in Rat Myocardial Ischaemia–Reperfusion

Life
(1) Background: Years of research have identified ischemic preconditioning (IPC) as a crucial endogenous protective mechanism against myocardial ischemia–reperfusion injury, enhancing the myocardial cell’s tolerance to subsequent ischemic damage.
Jia-Yuan Zhang, Szu-Kai Fu, Hsia-Ling Tai, Kuo-Wei Tseng, Chia-Yu Tang, Chia-Hsien Yu, Chang-Chi Lai   +6 more
doaj   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

Pharmacological preconditioning of resveratrol in ischemic / reherfusion injury: the role of nitric oxide

Кубанский научный медицинский вестник, 2015
The article presents the results of studies of the effect of distant preconditioning by creating short-term limb ischemia and pharmacologic preconditioning of resveratrol on the size of myocardial necrosis and the level of troponin I in serum after ...
L. M. Danilenko, M. V. Pokrovsky, I. A. Tatarenkova, V. V. Elagin, O. I. Bratchikov   +4 more
doaj  

Connexins and Nitric Oxide Inside and Outside Mitochondria: Significance for Cardiac Protection and Adaptation

Frontiers in Physiology, 2018
Irreversible myocardial damage happens in the presence of prolonged and severe ischemia. Several phenomena protect the heart against myocardial infarction and other adverse outcomes of ischemia and reperfusion (IR), namely: hibernation related to stunned
Maria Shvedova, Yana Anfinogenova, Yana Anfinogenova, Sergey V. Popov, Dmitriy N. Atochin, Dmitriy N. Atochin   +5 more
doaj   +1 more source

Remote and Anesthetic-Induced Myocardial Preconditioning Is Preserved in Atherosclerotic LDL Receptor-/- Mice In Vivo

Cardiovascular Therapeutics, 2021
Introduction. In the animal model, preconditioning is a powerful weapon against ischemic damage. The reason why the human heart cannot be protected from ischemic damage by preconditioning remains unclear.
Walter Petermichl, Kathrin Eglmeier, Henriette Hesse, Michael Gruber, Bernhard Graf, Andre Bredthauer, Andreas Redel   +6 more
doaj   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

O pré-condicionamento isquêmico influencia a contratilidade ventricular na cirurgia sem extracorpórea Ischemic preconditioning influence ventricular function in off-pump revascularization surgery

Arquivos Brasileiros de Cardiologia, 2010
FUNDAMENTO: O pré-condicionamento isquêmico é um método que prepara e protege a célula para suportar um período de isquemia prolongada com menor dano celular possível.
José Ernesto Succi, Luís Roberto Gerola, Guilherme Menezes Succi, Renata A.C.F. de Almeida, Leonardo Sérgio Rocha Novais, Bruno Rocha   +5 more
doaj   +1 more source