Results 21 to 30 of about 10,945 (163)
Advances in Interventional Cardiology, 2017 Introduction : Myocardial injury after percutaneous coronary intervention (PCI) occurs in approximately 30% of procedures, and is related to worse prognosis.
Mustafa A. Yılmaztepe +7 more
doaj +1 more source
Impact of hypoglycemic agents on myocardial ischemic preconditioning
World Journal of Diabetes, 2014 Murry et al in 1986 discovered the intrinsic mechanism of profound protection called ischemic preconditioning. The complex cellular signaling cascades underlying this phenomenon remain controversial and are only partially understood. However, evidence suggests that adenosine, released during the initial ischemic insult, activates a variety of G protein-
Rosa Maria, Rahmi Garcia +2 more
openaire +2 more sources
Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism
Advanced Science, EarlyView.Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards +8 more
wiley +1 more source
Cardiac Remote Conditioning and Clinical Relevance: All Together Now!
Engineering, 2015 Acute myocardial infarction (AMI) is the leading cause of death and disability worldwide. Timely reperfusion is the standard of care and results in decreased infarct size, improving patient survival and prognosis.
Kristin Luther +4 more
doaj +1 more source
Extracellular Adenosine Formation by Ecto-5'-Nucleotidase (CD73) Is No Essential Trigger for Early Phase Ischemic Preconditioning. [PDF]
PLoS ONE, 2015 Adenosine is a powerful trigger for ischemic preconditioning (IPC). Myocardial ischemia induces intracellular and extracellular ATP degradation to adenosine, which then activates adenosine receptors and elicits cardioprotection.
Georg Wolff +2 more
doaj +1 more source
Advanced Science, EarlyView.Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng +15 more
wiley +1 more source
Ischemic preconditioning and myocardial infarction: An update and perspective [PDF]
Drug Discovery Today: Disease Mechanisms, 2007 Myocardial infarction is the leading cause of mortality in Western societies with annual expenditures of $431.8 billion spent on coronary artery disease in man. Therapeutics to combat infarction from myocardial injury, based on studies of ischemic preconditioning (IPC), are currently in progress.
Eric R, Gross, Garrett J, Gross
openaire +2 more sources
Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury
Med Research, EarlyView.ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang +13 more
wiley +1 more source
The ischemic preconditioning effect of adenosine in patients with ischemic heart disease
Cardiovascular Ultrasound, 2009 Introduction In vivo and in vitro evidence suggests that adenosine and its agonists play key roles in the process of ischemic preconditioning. The effects of low-dose adenosine infusion on ischemic preconditioning have not been thoroughly studied in ...
Berglund Margareta +4 more
doaj +1 more source
Med Research, EarlyView.ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source