Results 41 to 50 of about 10,945 (163)
The Journal of Physiology, EarlyView.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti +2 more
wiley +1 more source
Arquivos Brasileiros de Cardiologia, 2010 FUNDAMENTO: O pré-condicionamento isquêmico é um método que prepara e protege a célula para suportar um período de isquemia prolongada com menor dano celular possível.
José Ernesto Succi +5 more
doaj +1 more source
Hyperbaric Oxygen Preconditioning Alleviates Myocardial Ischemic Injury in Rats
Experimental Biology and Medicine, 2008 It has been shown that after ischemia-reperfusion, application of hyperbaric oxygen (HBO) reduces cardiac injury. In this study we tested the hypothesis that HBO preconditioning reduces injury to the ischemic myocardium. One hundred and eight adult male Sprague-Dawley rats (250–280 g) were randomly divided into four groups: normoxia + sham surgery (CS)
Cuihong, Han +8 more
openaire +2 more sources
Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury
The Journal of Physiology, EarlyView.Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich +5 more
wiley +1 more source
Life(1) Background: Years of research have identified ischemic preconditioning (IPC) as a crucial endogenous protective mechanism against myocardial ischemia–reperfusion injury, enhancing the myocardial cell’s tolerance to subsequent ischemic damage.
Jia-Yuan Zhang +6 more
doaj +1 more source
Frontiers in Physiology, 2018 Irreversible myocardial damage happens in the presence of prolonged and severe ischemia. Several phenomena protect the heart against myocardial infarction and other adverse outcomes of ischemia and reperfusion (IR), namely: hibernation related to stunned
Maria Shvedova +5 more
doaj +1 more source
Effects of naloxone on myocardial ischemic preconditioning in humans
Journal of the American College of Cardiology, 1999 We attempted to establish whether naloxone, an opioid receptor antagonist, abolishes the adaptation to ischemia observed in humans during coronary angioplasty after repeated balloon inflations.Experimental studies indicate that myocardial opioid receptors are involved in ischemic preconditioning.Twenty patients undergoing angioplasty for an isolated ...
Tomai F +8 more
openaire +3 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev +7 more
wiley +1 more source
Кубанский научный медицинский вестник, 2015 The article presents the results of studies of the effect of distant preconditioning by creating short-term limb ischemia and pharmacologic preconditioning of resveratrol on the size of myocardial necrosis and the level of troponin I in serum after ...
L. M. Danilenko +4 more
doaj