Results 81 to 90 of about 42,902 (229)

Myocardial apoptosis and ischemic preconditioning [PDF]

Cardiovascular Research, 2002
Necrosis and apoptosis are two forms of cell death in the myocardium that have been associated with ischemia and reperfusion. Although it has been well documented that necrosis, as a major form of myocyte cell death, rapidly leads to a destruction of a large group of cells after myocardial ischemia and reperfusion, the induction of apoptosis in ...
Zhi-Qing, Zhao, Jakob, Vinten-Johansen
openaire   +2 more sources

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Improved resistance to ischemia and reperfusion, but impaired protection by ischemic preconditioning in patients with type 1 diabetes mellitus: a pilot study

Cardiovascular Diabetology, 2012
Background In patients with type 1 diabetes mellitus (T1DM), cardiovascular events are more common, and the outcome following a myocardial infarction is worse than in nondiabetic subjects.
Engbersen Richard, Riksen Niels P, Mol Marc J, Bravenboer Bert, Boerman Otto C, Meijer Patrick, Oyen Wim JG, Tack Cees, Rongen Gerard A, Smits Paul   +9 more
doaj   +1 more source

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection [PDF]

, 2004
Background - Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial reactive oxygen species (ROS) signaling.
Duchen, M, Hausenloy, D, Wynne, A, Yellon, D   +3 more
core   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Cardiac surveillance in immune checkpoint inhibitor therapy: Insights from the Essen Cardio‐oncology Registry

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, offering improvements in survival across various malignancies. However, their toxicities pose a major challenge for cardio‐oncology units. Despite their growing importance, data on effectiveness of such specialized units in mitigating ICI‐associated ...
Elias Haj‐Yehia, Lisa Zimmer, Lena Lampe, Dimitra Vlachopoulou, Matthias Totzeck, Tienush Rassaf, Raluca I. Mincu   +6 more
wiley   +1 more source

Sequential Wnt Agonist then Antagonist Treatment Accelerates Tissue Repair and Minimizes Fibrosis [PDF]

, 2019
Tissue fibrosis compromises organ function and occurs as a potential long-term outcome in response to acute tissue injuries. Currently, lack of mechanistic understanding prevents effective prevention and treatment of the progression from acute injury to ...
Fu, Haiyan, Huang, Sui, Liu, Youhua, Tian, Xiao-Jun, Wang, Xiaojie, Xing, Jianhua, Zhang, Rong, Zhou, Dong   +7 more
core   +2 more sources

Mesenchymal stem cell-based therapy for ischemic stroke [PDF]

, 2016
Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available.
Anderson, JD, Bardini, RL, Bauer, G, Bramlett, CS, Chedin, F, Contreras, Z, Dunbar, GL, El-Andaloussi, S, Fiehn, O, Fink, KD, Fury, B, Hendrix, KJ, Hoon, M, Hwang, B, Johansson, HJ, Lehtiö, J, Mulligan, MS, Nolta, JA, Pham, MT, Rossignol, J, Showalter, M   +20 more
core   +2 more sources

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, EarlyView.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Alternation of gene expression in brain-derived exosomes after cerebral ischemic preconditioning in mice

Heliyon
Aims: Cerebral ischemic preconditioning is a neuroprotective therapy against cerebral ischemia and ischemia-reperfusion injury. This study aims to demonstrate the alternation of gene expression in exosomes from brain tissue of mice after ischemic ...
He Li, Xiaoxi Zhang, Hongye Xu, Hanchen Liu, Yongxin Zhang, Lei Zhang, Yu Zhou, Yongwei Zhang, Jianmin Liu, Mei Jing, Ping Zhang, Pengfei Yang   +11 more
doaj   +1 more source