Results 91 to 100 of about 865,811 (229)

ACE inhibitor quinapril in the treatment of chronic cardiac failure

Терапевтический архив, 2003
Aim. To assess effectiveness of A CE inhibitor quinapril in patients with moderate cardiac failure of ischemic etiology. Material and methods. 20 patients received quinapril in a daily dose 20 mgfor 6 months.
A N Gadzhiev
doaj  

Rational modulation of the innate immune system for neuroprotection in ischemic stroke

Frontiers in Neuroscience, 2015
The innate immune system plays a dualistic role in the evolution of ischemic brain damage and has also been implicated in ischemic tolerance produced by different conditioning stimuli.
Diana eAmantea, Giuseppe eMicieli, Cristina eTassorelli, Cristina eTassorelli, Maria I Cuartero, Ivan eBallesteros, Michelangelo eCerto, Maria A Moro, Ignacio eLizasoain, Giacinto eBagetta, Giacinto eBagetta   +10 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Peculiarities of Ischemic Heart Disease Course and Treatment in Patients with Glucose Metabolism Impairment and Diabetes Mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2015
Combination of ischemic heart disease and diabetes mellitus is characterized by certain features of clinical picture and insufficient effectiveness of treatment of ischemic heart disease.
O.M. Radchenko, O.Ya. Кoroliuk
doaj   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Ischemic tolerance of the brain from bench to bedside [PDF]

, 2006
Neurons can be preconditioned by various procedures to resist ischemic events. The preconditioning mechanism induced is characterized by a brief episode of ischemia that renders the brain more resistant against subsequent longer ischemic events.
Buchfelder, M., Schaller, B. J.
core   +1 more source

Global SUMOylation is a Molecular Mechanism Underlying Hypothermia-induced Ischemic Tolerance

Frontiers in Cellular Neuroscience, 2014
The molecular mechanisms underlying hypothermic neuroprotection have yet to be fully elucidated. Herein we demonstrate that global SUMOylation, a form of post-translational modification with the Small Ubiquitin-like MOdifer, participates in the ...
Yang-ja eLee, Yongshan eMou, Dace eKlimanis, Joshua D Bernstock, John M. Hallenbeck   +4 more
doaj   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Synergistic effects of low-level stress and a Western diet on metabolic homeostasis, mood, and myocardial ischemic tolerance

, 2020
How low-level psychological stress and overnutrition interact in influencing cardiometabolic disease is unclear. Mechanistic overlaps suggest potential synergies; however, findings are contradictory. We test whether low-level stress and Western diet (WD)
Headrick, John P, Peart, Jason N., Griffith, Tia A, Tai, Wei Shan, Cox, Amanda, Helman, Tessa, Du Toit, Eugene F., Griffith, Tia A., Wendt, Lauren, O'Connor, Dylan, Stapelberg, Nicolas J. C., Du Toit, Eugene F, Tai, Fiona, Peart, Jason N, Stapelberg, Nicolas JC, Headrick, John P.   +15 more
core   +1 more source

The relation between BMI with exercise test in individuals with cardiac ischemic pains

Journal of Mazandaran University of Medical Sciences, 2009
(Received 19 Nov, 2008; Accepted 28 Jan, 2009)AbstractBackground and purpose: Prevalence of over weight and obesity is increasing in the world. Those over weight are more susceptible to cardiovascular diseases than other individual's.
Ravanbakhsh Esmaeili1, Najibeh Rastgarnia4, Reza Ali Mohammadpour5, Ali Ghaemian3, Vida Shafipour2, Hedayat Jafari, Ebrahim Nasiri   +6 more
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