Results 11 to 20 of about 493 (138)

Transcriptome-wide dynamics of m6A methylation in ISKNV and Siniperca chuatsi cells infected with ISKNV [PDF]

BMC Genomics
Infectious spleen and kidney necrosis virus (ISKNV) is a highly virulent and rapidly transmissible fish virus that poses threats to the aquaculture of a wide variety of freshwater and marine fish.
Qijin Miao, Jing Jiang, Siyou Huang, Jie Gao, Qingqing Liu, Rui Zheng, Yiling Kang, Changjun Guo, Jianguo He, Junfeng Xie   +9 more
doaj   +4 more sources

Hypermethylated genome of a fish vertebrate iridovirus ISKNV plays important roles in viral infection [PDF]

Communications Biology
Iridoviruses are nucleocytoplasmic large dsDNA viruses that infect invertebrates and ectothermic vertebrates. The hypermethylated genome of vertebrate iridoviruses is unique among animal viruses.
Mincong Liang, Weiqiang Pan, Yanlin You, Xiaowei Qin, Hualong Su, Zhipeng Zhan, Shaoping Weng, Changjun Guo, Jianguo He   +8 more
doaj   +4 more sources

High-throughput virtual screening of marine algae metabolites as high-affinity inhibitors of ISKNV major capsid protein: An analysis of in-silico models and DFT calculation to find novel drug molecules for fighting infectious spleen and kidney necrosis virus (ISKNV)

Heliyon, 2023
Infectious Spleen and Kidney Necrosis Virus (ISKNV) is linked to severe infections that cause significant financial losses in global aquaculture. ISKNV enters the host cell through its major capsid protein (MCP), and the resulting infection can lead to ...
Moslema Jahan Mou, Saloa Sanjida, Nasim Habib   +2 more
exaly   +5 more sources

Development of a Double-Antibody Sandwich ELISA for Rapid Detection of the MCP Antigen Concentration in Inactivated ISKNV Vaccines [PDF]

Vaccines, 2021
Infectious spleen and kidney necrosis virus (ISKNV) resulted in severe systemic diseases with high morbidity and mortality in Siniperca chuatsi. Vaccination is the primary method for effective prevention and control of these diseases.
Hongru Liang, Lixi Zhang, Xiaozhe Fu, Qiang Lin, Lihui Liu, Yinjie Niu, Xia Luo, Zhibin Huang, Ningqiu Li   +8 more
doaj   +3 more sources

Development of a gene-deleted live attenuated candidate vaccine against fish virus (ISKNV) with low pathogenicity and high protection [PDF]

iScience, 2021
Summary: Aquaculture provides important food, nutrition, and income sources for humans. However, aquaculture industry is seriously threatened by viral diseases.
Ruoyun Zeng, Weiqiang Pan, Yifan Lin, Jian He, Zhiyong Luo, Zhimin Li, Shaoping Weng, Jianguo He, Changjun Guo   +8 more
doaj   +3 more sources

Molecular mechanism of infectious spleen and kidney necrosis virus in manipulating the hypoxia-inducible factor pathway to augment virus replication [PDF]

Virulence
Infectious spleen and kidney necrosis virus (ISKNV), a member of the genus Megalocytivirus in the family Iridoviridae, can infect over 50 fish species and cause significant economic losses in Asia.
Jian He, Yang Yu, Wenhui Liu, Zhimin Li, Zhang Qi, Shaoping Weng, Changjun Guo, Jianguo He   +7 more
doaj   +2 more sources

Development of Duplex Loop-Mediated Isothermal Amplification with Hydroxynaphthol Blue for Detection of Infectious Spleen and Kidney Necrosis Virus and Aeromonas hydrophila in Chinese Perch (Siniperca chuatsi) [PDF]

Microorganisms
Bacterial sepsis caused by Aeromonas hydrophila (A. hydrophila) and infectious spleen and kidney necrosis virus disease (ISKNVD) caused by infectious spleen and kidney necrosis virus (ISKNV) frequently result in significant mortality among Chinese perch (
Xiao He, Jingyi Wu, Xu Tan, Sunan Xu, Weiguang Kong, Xiaodan Liu   +5 more
doaj   +2 more sources

Non-Targeted UHPLC-Q-TOF/MS-Based Metabolomics Reveals a Metabolic Shift from Glucose to Glutamine in CPB Cells during ISKNV Infection Cycle

Metabolites, 2019
Infectious spleen and kidney necrosis virus (ISKNV) has caused serious economic losses in the cultured mandarin fish (Siniperca chuatsi) industry in China.
Qiang Lin, Yinjie Niu, Ningqiu Li
exaly   +3 more sources

Rapid, sensitive, and visual detection of mandarin fish ranavirus and infectious spleen and kidney necrosis virus using an RPA-CRISPR/Cas12a system [PDF]

Frontiers in Microbiology
Iridoviruses are large cytoplasmic icosahedral viruses that contain dsDNA. Among them, mandarin fish ranavirus (MRV) and infectious spleen and kidney necrosis virus (ISKNV) are particularly notable due to their high contagiousness and pathogenicity ...
Zhoutao Lu, Mincong Liang, Chuanrui Li, Yichun Xu, Shaoping Weng, Jianguo He, Changjun Guo   +6 more
doaj   +2 more sources

scTRIM44 Positively Regulated Siniperca Chuatsi Rhabdovirus Through RIG-I- and MDA5-Mediated Interferon Signaling [PDF]

Viruses
Tripartite Motif-Containing 44 (TRIM44) is responsible for cancers, neurodegenerative diseases, and viral infections. However, the role of Siniperca chuatsi TRIM44 (scTRIM44) during viral infection remains unclear.
Yinjie Niu, Xinmei Yang, Hongru Liang, Xia Luo, Baofu Ma, Qiang Lin, Xiaozhe Fu, Ningqiu Li   +7 more
doaj   +2 more sources