Results 31 to 40 of about 692 (163)

Zinc ions attenuates iridovirus infection through regulation of ferroptosis pathways [PDF]

Cell Death Discovery
Zinc is widely acknowledged as an inducer of ferroptosis, a type of regulated cell death process. Generally, ferroptosis is known to facilitate viral replication.
Yanlin You, Mincong Liang, Xueqian Cao, Weiqiang Pan, Jian He, Kun Wu, Shaoping Weng, Jianguo He, Changjun Guo   +8 more
doaj   +2 more sources

Multiplex polymerase chain reaction (PCR) with Nanopore sequencing for sequence-based detection of four tilapia pathogens [PDF]

PeerJ
Background Tilapia aquaculture faces significant threats posed by four prominent pathogens: tilapia lake virus (TiLV), infectious spleen and kidney necrosis virus (ISKNV), Francisella orientalis, and Streptococcus agalactiae.
Jérôme Delamare-Deboutteville, Watcharachai Meemetta, Khaettareeya Pimsannil, Han Ming Gan, Laura Khor, Mohan Chadag, Ha Thanh Dong, Saengchan Senapin   +7 more
doaj   +3 more sources

The viral TRAF protein (ORF111L) from infectious spleen and kidney necrosis virus interacts with TRADD and induces caspase 8-mediated apoptosis.

PLoS ONE, 2012
Infectious spleen and kidney necrosis virus (ISKNV) is the type species of the Megalocytivirus genus of the Iridoviridae family. It causes a serious and potentially pandemic disease in wild and cultured fishes.
Bai-Liang He, Ji-Min Yuan, Lu-Yun Yang, Jun-Feng Xie, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He   +6 more
doaj   +2 more sources

The Stability and Efficency of CPB Cells Were Acclimated for Virus Proliferation [PDF]

Vaccines
Background: Vaccinations are still the most effective means of preventing and controlling fish viral diseases, and cells are an important substrate for the production of a viral vaccine.
Yinjie Niu, Saiya Ma, Hongru Liang, Xiaozhe Fu, Baofu Ma, Qiang Lin, Xia Luo, Ningqiu Li   +7 more
doaj   +2 more sources

Mandarin fish tankyrase 1-like protein regulates the Wnt/β-catenin pathway and facilitates the infectious spleen and kidney necrosis virus replication [PDF]

Comparative Immunology Reports
Tankyrase (TNKS), a poly (ADP-ribose) polymerase (PARP) protein, mediates the PARylation of substrates, ultimately guiding them towards proteasome-dependent degradation or altering their localization.
Zhimin Li, Yashan Wu, Jian He, Kun Wu, Shaoping Weng, Changjun Guo, Jianguo He   +6 more
doaj   +2 more sources

Experimental Infection and the Effects of Temperature on the Pathogenicity of the Infectious Spleen and Kidney Necrosis Virus in Juvenile Nile Tilapia (Oreochromis niloticus) [PDF]

Animals
The infectious spleen and kidney necrosis virus (ISKNV) is one of the most important emerging viral pathogens for Nile tilapia (Oreochromis niloticus) farming. While prevalent worldwide, it has recently been detected in Brazil.
Tarcísio Martins França e Silva, Guilherme Alves de Queiróz, Carlos Augusto Gomes Leal   +2 more
doaj   +2 more sources

Microbiome and Pathobiome Characterization in Farmed Barramundi (Lates calcarifer) During and Post Scale Drop Disease Outbreaks. [PDF]

J Fish Dis
ABSTRACT Large‐scale double‐digest RAD sequencing (ddRADseq) datasets generated for genotyping are increasingly available in aquaculture, yet their unmapped reads remain largely unexplored for pathogen surveillance. Here, we evaluated the utility and limitations of repurposing unmapped ddRADseq reads to examine pathogen‐associated and disease ...
Vu NT, Shen X, Gibson-Kueh S, Carrai M, Terence C, Poon ZWJ, Nelson SP, Senapin S, Dong HT, Loh JY, Jerry DR, Domingos JA.   +11 more
europepmc   +2 more sources

Risk of Spread of Megalocytivirus pagrus1 (Infectious Spleen and Kidney Necrosis Virus) From Frozen Fillets. [PDF]

J Fish Dis
ABSTRACT Infectious spleen and kidney necrosis virus (ISKNV) is a significant threat to global aquatic food security by causing large‐scale mortality in the aquaculture of tilapia (Oreochromis niloticus) and mandarin fish (Siniperca chuatsi). ISKNV is a genogroup of Megalocytivirus pagrus1, along with RSIV and TRBIV, and their recent listing as WOAH ...
Becker JA, Hick PM, Megarani D, Siler H, Pierezan F, Gray SN, Subramaniam K.   +6 more
europepmc   +2 more sources

The Inactivated ISKNV-I Vaccine Confers Highly Effective Cross-Protection against Epidemic RSIV-I and RSIV-II from Cultured Spotted Sea Bass Lateolabrax maculatus

Microbiology Spectrum, 2023
The genus Megalocytivirus of the family Iridoviridae is composed of two distinct species, namely, infectious spleen and kidney necrosis virus (ISKNV) and scale drop disease virus (SDDV), and both are important causative agents in a variety of bony fish ...
Weixuan Fu, Yong Li, Yuting Fu, Wenfeng Zhang, Panpan Luo, Qianqian Sun, Fangzhao Yu, Shaoping Weng, Wangdong Li, Jianguo He, Chuanfu Dong   +10 more
doaj   +1 more source

Mandarin Fish (Siniperca chuatsi) p53 Regulates Glutaminolysis Induced by Virus via the p53/miR145-5p/c-Myc Pathway in Chinese Perch Brain Cells

Microbiology Spectrum, 2022
p53, as an important tumor suppressor protein, has recently been implicated in host antiviral defense. The present study found that the expression of mandarin fish (Siniperca chuatsi) p53 (Sc-p53) was negatively associated with infectious spleen and ...
Caimei Ye, Shangui Liu, Ningqiu Li, Shaozhi Zuo, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Xiaozhe Fu   +8 more
doaj   +1 more source