Results 21 to 30 of about 692 (163)

Evaluation of a Low-Temperature Immersion Immunization Strategy for the Infectious Spleen and Kidney Necrosis Virus orf037l Gene-Deleted Attenuated Vaccine [PDF]

Vaccines
Background: Infectious spleen and kidney necrosis virus (ISKNV) poses a significant threat to aquaculture sustainability, particularly affecting mandarin fish (Siniperca chuatsi) and causing significant economic losses. Methods: To address this challenge,
Weiqiang Pan, Jiajie Fu, Ruoyun Zeng, Mingcong Liang, Yanlin You, Zhipeng Zhan, Zhoutao Lu, Shaoping Weng, Changjun Guo, Jianguo He   +9 more
doaj   +3 more sources

First report of Iridovirus (ISKNV) infection in Israeli mariculture gilthead sea bream (Sparus aurata) at the Mediterranean Sea [PDF]

Israeli Journal of Aquaculture - Bamidgeh, 2021
Megalocytiviruses have caused mass mortalities in various farmed fish species, both edible and ornamental. Infectious spleen and kidney necrosis virus (ISKNV) belongs to this family of viruses and induces lethal diseases in cultured fish.
Hanna Hershko, Tamir Ofek, Margarita Smirnov, Tetsuzan B. Ron, Ofek, Tamir, Smirnov, Margarita, Ron, Tetsuzan B., Hershko, Hanna   +7 more
core   +4 more sources

Development of a gene-deleted live attenuated candidate vaccine against fish virus (ISKNV) with low pathogenicity and high protection [PDF]

iScience, 2021
Summary: Aquaculture provides important food, nutrition, and income sources for humans. However, aquaculture industry is seriously threatened by viral diseases.
Ruoyun Zeng, Weiqiang Pan, Yifan Lin, Jian He, Zhiyong Luo, Zhimin Li, Shaoping Weng, Jianguo He, Changjun Guo   +8 more
doaj   +3 more sources

A New Cell Line Derived from the Caudal Fin of the Dwarf Gourami (Trichogaster lalius) and Its Susceptibility to Fish Viruses

Biology, 2023
The detection of megalocytiviruses, especially the infectious spleen and kidney necrosis virus (ISKNV), in ornamental fish has increased with the rapid growth of the ornamental fish industry.
Ye-Jin Jeong, Kwang-Il Kim
doaj   +2 more sources

Accelerated Metabolite Levels of Aerobic Glycolysis and the Pentose Phosphate Pathway Are Required for Efficient Replication of Infectious Spleen and Kidney Necrosis Virus in Chinese Perch Brain Cells

Biomolecules, 2019
Glucose is a main carbon and energy source for virus proliferation and is usually involved in the glycolysis, pentose phosphate pathway (PPP), and tricarboxylic acid cycle (TCA cycle) pathways.
Xixi Guo, Shiwei Wu, Ningqiu Li, Qiang Lin, Lihui Liu, Hongru Liang, Yinjie Niu, Zhibin Huang, Xiaozhe Fu   +8 more
doaj   +2 more sources

The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells

Microbiology Spectrum, 2022
Under oxidative stress, viruses prefer glycolysis as an ATP source, and glutamine is required as an anaplerotic substrate to replenish the TCA cycle. Infectious spleen and kidney necrosis virus (ISKNV) induces reductive glutamine metabolism in the host ...
Xiaozhe Fu, Kejin Li, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Lihui Liu, Ningqiu Li   +7 more
doaj   +3 more sources

Infectious Spleen and Kidney Necrosis Virus (ISKNV) Triggers Mitochondria-Mediated Dynamic Interaction Signals via an Imbalance of Bax/Bak over Bcl-2/Bcl-xL in Fish Cells

Viruses, 2022
The molecular pathogenesis of infectious spleen and kidney necrosis virus (ISKNV) infections is important but has rarely been studied in connection to host organelle behavior.
Pin-Han Chen, Tsai-Ching Hsueh, Jen-Leih Wu, Jiann-Ruey Hong   +3 more
doaj   +2 more sources

A novel viral SOCS from infectious spleen and kidney necrosis virus: interacts with Jak1 and inhibits IFN-α induced Stat1/3 activation. [PDF]

PLoS ONE, 2012
Interferon (IFN)-induced Janus kinase (Jak)/signal transducer and activator of transcription (Stat) pathway is important in controlling immune responses and is negatively response-regulated by the suppressor of cytokine signaling (SOCS) proteins. However,
Chang-Jun Guo, Li-Shi Yang, Ying-Fen Zhang, Yan-Yan Wu, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He   +6 more
doaj   +2 more sources

Rapid, sensitive, and visual detection of mandarin fish ranavirus and infectious spleen and kidney necrosis virus using an RPA-CRISPR/Cas12a system [PDF]

Frontiers in Microbiology
Iridoviruses are large cytoplasmic icosahedral viruses that contain dsDNA. Among them, mandarin fish ranavirus (MRV) and infectious spleen and kidney necrosis virus (ISKNV) are particularly notable due to their high contagiousness and pathogenicity ...
Zhoutao Lu, Mincong Liang, Chuanrui Li, Yichun Xu, Shaoping Weng, Jianguo He, Changjun Guo   +6 more
doaj   +2 more sources

scTRIM44 Positively Regulated Siniperca Chuatsi Rhabdovirus Through RIG-I- and MDA5-Mediated Interferon Signaling [PDF]

Viruses
Tripartite Motif-Containing 44 (TRIM44) is responsible for cancers, neurodegenerative diseases, and viral infections. However, the role of Siniperca chuatsi TRIM44 (scTRIM44) during viral infection remains unclear.
Yinjie Niu, Xinmei Yang, Hongru Liang, Xia Luo, Baofu Ma, Qiang Lin, Xiaozhe Fu, Ningqiu Li   +7 more
doaj   +2 more sources