Results 231 to 240 of about 121,748 (297)

Efficacy and safety of anifrolumab across organ domains of systemic lupus erythematosus: A systematic review and meta‐analysis

Rheumatology &Autoimmunity, EarlyView.
A systematic review and meta‐analysis were conducted to review all clinical trial results of anifrolumab for treating systemic lupus erythematosus. Fourteen studies were included comprising 1322 patients and five studies were meta‐analyzed. It was found that anifrolumab 300 mg IV led to clinical improvement across composite lupus scores, cutaneous ...
Yomna W. Mahmoud, Mohamed Ramadan S., Doaa Radwan G., Mariam S. Abdulhafiz, Yassin M. El‐Shnawy, Alaa Alaa H., Sara Naser Sebie, Maryam A. Elashmawi, Husni Zahi M., Mohammad T. Abuawwad, Mohammad J. Taha, Abdulqadir J. Nashwan   +11 more
wiley   +1 more source

Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment. [PDF]

Bioengineering (Basel)
Gabriel Silvério Scholl V, Todeschini Justus L, Girotto OS, Karine Pasqual K, Garcia MHH, da Silva Petronio FG, de Moraes AF, Maria Barbalho S, Araújo AC, Fornari Laurindo L, Camargo CP, Miglino MA.   +11 more
europepmc   +1 more source

Plasma Functionalization Enables Diffusion Control of Reactive Oxygen Species

Small, EarlyView.
Plasma surface functionalization of thin films enables controlled delivery of reactive oxygen species (ROS) generated by catalytic coatings. This approach ensures efficacy driven by radical activity rather than direct redox reactions or leaching. The selective release of radicals with distinct lifetimes is linked to both antimicrobial and antiviral ...
Paula Navascués, Flaela Kalemi, Flavia Zuber, Philipp Meier, Ludovica M. Epasto, Michał Góra, Barbara Hanselmann, Svetlana Kucher, Enrica Bordignon, Qun Ren, Giacomo Reina, Dirk Hegemann   +11 more
wiley   +1 more source

Polyfunctional T follicular helper cells drive checkpoint-inhibitor diabetes and are targeted by JAK inhibitor therapy. [PDF]

JCI Insight
Huang NL, Ortega JG, Kimbrell K, Lee J, Scott LN, Peluso EM, Wang SJ, Kao EY, Kim K, Olay J, Nguyen JN, Quandt Z, Angell TE, Su MA, Lechner MG.   +14 more
europepmc   +1 more source

Surface‐Engineering of Pancreatic Islets with Chitosan Microparticles to Inhibit IBMIR in Islet Xenotransplantation

Small, EarlyView.
A novel surface engineering approach using chitosan microparticles (CSMP) is developed to enable stable islet conjugation and high‐capacity heparin (HEP) loading. The resulting HEP/CSMP‐islets maintain viability and function and significantly suppress IBMIR after intraportal transplantation in diabetic mice. This strategy offers a simple, biocompatible
Manju Shrestha, Tiep Tien Nguyen, Junhyeung Park, Dinesh Chaudhary, Rabyya Kausar, Yu Seok Youn, Ji Hoon Jeong, Jung Heon Lee, Sei Won Lee, Hye Yun Park, Simmyung Yook, Jee‐Heon Jeong   +11 more
wiley   +1 more source

Proinflammatory cytokine-induced alpha cell impairment in human islet microtissues is partially restored by dual incretin receptor agonism. [PDF]

Diabetologia
Henriksen K, Rufer C, Title AC, Jawurek S, Hartmann B, Holst JJ, Knop FK, Yesildag B, Størling J.   +8 more
europepmc   +1 more source

Cryomicroneedle Arrays for Biotherapeutics Delivery

Small Science, EarlyView.
CryoMNs for biotherapeutic delivery to treat various diseases. CryoMNs: cryomicroneedles. Biotherapy offers a promising approach for treating a variety of diseases. However, the lack of advanced delivery systems remains a significant barrier to improve the efficacy, safety, and cost‐effectiveness of biotherapeutics.
Chunli Yang, Li Zhang, Angxi Zhou, Siyi Wang, Ya Ren, Maya Xiang, Run Tian, Yang Yu, Rong Li, Maling Gou   +9 more
wiley   +1 more source

Effect of Maternal Hyperglycemia on Fetal Pancreatic Islet Development. [PDF]

Biology (Basel)
Dias CP, Teixeira Paiva de Moraes MR, Correia Barrence FA, Balbino da Silva CS, Smuckzec B, Ortis F, Zorn TMT.   +6 more
europepmc   +1 more source

Spatiotemporal Interrogation of Single Spheroids Using Multiplexed Nanoplasmonic‐Fluorescence Imaging

Small Methods, EarlyView.
This work introduces a multiplexed imaging platform that integrates nanoplasmonic sensing with fluorescence microscopy for concomitant monitoring of extraspheroid secretions and intraspheroid features over extended periods with spatiotemporal resolution.
Saeid Ansaryan, Yung‐Cheng Chiang, Yen‐Cheng Liu, Jiayi Tan, Luis Francisco Lorenzo‐Martín, Matthias P. Lutolf, Genrich Tolstonog, Hatice Altug   +7 more
wiley   +1 more source

Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors. [PDF]

Diabetologia
Swensen AC, Piehowski PD, Chen J, Chan XY, Kelly SS, Petyuk VA, Moore RJ, Nasif L, Butterworth EA, Atkinson MA, Kulkarni RN, Campbell-Thompson M, Mathews CE, Qian WJ.   +13 more
europepmc   +1 more source