Results 71 to 80 of about 121,748 (297)

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

Advanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang   +9 more
wiley   +1 more source

A Human Immuno‐Lung Organoid Model to Study Macrophage‐Mediated Lung Cell Senescence Upon SARS‐CoV‐2 Infection

Advanced Science, EarlyView.
Immuno‐lung organoids are developed and used spatial transcriptomics to uncover how proinflammatory macrophages drive lung cell senescence via the THBS1–(ITGA3+ITGB1) axis in COVID‐19. To ensure broad accessibility, LungSpatialDB is created, an AI‐powered data portal, enabling intuitive exploration of spatial data and biological insights through ...
Yuling Han, Dongliang Leng, Tuo Zhang, Jian Ge, Yinshan Fang, Tiankun Lu, Xue Dong, Manoj S Nair, Neranjan de Silva, Zhaowei Han, Tiancheng Jiao, Yuanhao Huang, Meiqi Zhao, Anjali Saqi, Hanina Hibshoosh, Zihe Meng, Jenny Z Xiang, Chendong Pan, Yanjie Sun, David D. Ho, Todd Evans, Jie Liu, Liuliu Yang, Jianwen Que, Shuibing Chen   +24 more
wiley   +1 more source

Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site

Clinical and Developmental Immunology, 2013
Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment ...
Andrew R. Pepper, Boris Gala-Lopez, Oliver Ziff, A. M. James Shapiro   +3 more
doaj   +1 more source

ECD for Islet Transplantation [PDF]

, 2014
Pancreatic islet transplantation has the potential to become the most physiologically advantageous and minimally invasive procedure for the treatment of type 1 diabetes mellitus. Since the first clinical islet transplantation was performed at the University of Minnesota in 1974 [1], the results have been far from ideal for more than two decades in ...
Naotake Akutsu, Taihei Ito, Takashi Kenmochi, Takehide Asano   +3 more
openaire   +2 more sources

Theranostic Toolbox for Neutrophil Functionalization

Advanced Science, EarlyView.
Here, neutrophil‐specific fluorine nanoparticles additionally equipped with either activating or inhibiting peptides for a background‐free 19F MRI‐based nanotheranostic approach are engineered. It is demonstrated that this approach is suitable to visualize and concomitantly direct neutrophil functionality depending on the specific requirements to ...
Pascal Bouvain, Kay‐Matthias Thomy, Anika Maria Prinz, Bodo Steckel, Shiwa Kadir, Alexandra Röhs, Jonas Schmitz, Claudia Dohle, Matthias Karg, Maria Grandoch, Ulrich Flögel, Sebastian Temme   +11 more
wiley   +1 more source

Evolution of Danubian islets from Balta Ialomitei hydrographic system (Km 345-241) between 1908-2016

Scientific Annals of the Danube Delta Institute, 2018
The studied area is part of the Balta Ialomiţei hydrographical system and belongs to the lower sector of the Danube, being characterized by the many branches, secondary branches with islets between them, indicating a state of hydro morphological ...
IORDACHE Gabriel, BONDAR Constantin, ANGHEL Sorin , MALAGEANU Marian   +3 more
doaj   +1 more source

Polymer‐Driven Co‐Assembly of Achiral and Chiral Nanoparticles into Plasmonic Nanoclusters with Quantitatively Modulated Optical Chirality

Advanced Science, EarlyView.
This work describes the polymer‐mediated co‐assembly of chiral gold nanoarrows and achiral nanospheres into ABn plasmonic clusters enabling precise control over coordination number (n = 2–7) via pH modulation. Experimental and simulation results reveal a linear enhancement of optical chirality (g‐factor) with increasing n, attributed to electric field ...
Chongyang Yao, Huibin He, Weijia Kong, Liangyu Hu, Xiaoxue Shen, Jing Tao, Yutao Sang, Zhihong Nie   +7 more
wiley   +1 more source

Polymeric Approaches to Reduce Tissue Responses Against Devices Applied for Islet-Cell Encapsulation

Frontiers in Bioengineering and Biotechnology, 2019
Immunoisolation of pancreatic islets is a technology in which islets are encapsulated in semipermeable but immunoprotective polymeric membranes.
Shuixan Hu, Paul de Vos
doaj   +1 more source

Subgenome Partitioning and Polyploid Genome Evolution in the Loach Family Botiidae (Order Cypriniformes)

Advanced Science, EarlyView.
This study investigates subgenome evolution and polyploidy in Cypriniformes fish, revealing complex phylogenetic relationships and genomic dynamics. By applying advanced subgenome partitioning methods, it uncovers novel insights into transposon activity and gene fractionation.
Yunyun Lv, Jia Li, Yanping Li, Yu Huang, Qiang Lai, Zhengyong Wen, Jun Wang, Yang He, Jinrong Shi, Zejin Huang, Ying Jiang, Yves Van de Peer, Qiong Shi, Biwen Xie, Yongming Wang   +14 more
wiley   +1 more source