Results 71 to 80 of about 235,553 (209)

The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

eLife
The gain-of-function mutation in the TALK-1 K+ channel (p.L114P) is associated with maturity-onset diabetes of the young (MODY). TALK-1 is a key regulator of β-cell electrical activity and glucose-stimulated insulin secretion.
Arya Y Nakhe, Prasanna K Dadi, Jinsun Kim, Matthew T Dickerson, Soma Behera, Jordyn R Dobson, Shristi Shrestha, Jean-Philippe Cartailler, Leesa Sampson, Mark A Magnuson, David A Jacobson   +10 more
doaj   +1 more source

Antibodies to the Mr 64,000 (64K) protein in islet cell antibody positive non-diabetic individuals indicate high risk for impaired Beta-cell function [PDF]

, 1992
A prospective study of a normal childhood population identified 44 islet cell antibody positive individuals. These subjects were typed for HLA DR and DQ alleles and investigated for the presence of antibodies to the Mr 64,000 (64K) islet cell antigen ...
AC Tarn, AG Ziegler, BO Boehm, C Johnston, C Ricordi, GJ Bruining, H Bärmeier, JA Todd, JK Karjalainen, KM Spencer, M Bergua, M Landin-Olsson, M Trucco, MA Atkinson, MR Christie, P Vardi, S Baekkeskov, S Baekkeskov, S Srikanta, UK Laemmli, WA Scherbaum, WA Scherbaum, WJ Riley   +22 more
core   +1 more source

The physiological role of β-cell heterogeneity in pancreatic islet function

, 2021
Richard K.P. Benninger, Vira Kravets
openalex   +2 more sources

Human islet isolation and allotransplantation in 22 consecutive cases [PDF]

, 1992
This report provides our initial experience in islet isolation and intrahepatic allotransplantation in 21 patients. In group 1, 10 patients underwent combined liver-islet allotransplantation following upper-abdominal exenteration for cancer.
Alejandro, R, Carroll, PB, Demetris, AJ, Fung, JJ, Mintz, DH, Ricordi, C, Rodriguez Rilo, HL, Shapiro, R, Starzl, TE, Tzakis, AG, Zeng, Y   +10 more
core   +1 more source

Evolution of Danubian islets from Balta Ialomitei hydrographic system (Km 345-241) between 1908-2016

Scientific Annals of the Danube Delta Institute, 2018
The studied area is part of the Balta Ialomiţei hydrographical system and belongs to the lower sector of the Danube, being characterized by the many branches, secondary branches with islets between them, indicating a state of hydro morphological ...
IORDACHE Gabriel, BONDAR Constantin, ANGHEL Sorin , MALAGEANU Marian   +3 more
doaj   +1 more source

Improved Vascularization of Planar Membrane Diffusion Devices following Continuous Infusion of Vascular Endothelial Growth Factor

Cell Transplantation, 2000
Improving blood vessel formation around an immunobarrier device should improve the survival of the encapsulated tissue. In the present study we investigated the formation of new blood vessels around a planar membrane diffusion device (the Baxter ...
N. Trivedi, G. M. Steil, C. K. Colton, S. Bonner-Weir, G. C. Weir M.D.   +4 more
doaj   +1 more source

Preemptive Tolerogenic Delivery of Donor Antigens for Permanent Allogeneic Islet Graft Protection [PDF]

, 2014
Shusen Wang, Xiaomin Zhang, Lei Zhang, Jane Bryant, Taba Kheradmand, Bernhard J. Hering, Stephen D. Miller, Xunrong Luo   +7 more
openalex   +1 more source

Car@PLGA-NPs target gut microbiota-ER stress axis to combat diabetes

Frontiers in Cellular and Infection Microbiology
BackgroundPrevious studies have demonstrated that carvacrol (Car) ameliorates vascular and hepatic injury in db/db mice, but its low bioavailability limits clinical translation.MethodsTo address this, this study constructed carvacrol-loaded polymeric ...
Wei Zhao, Li Chen, Jing Qing, Zhujia Zhao, Lijuan Xiong, Pingzhen Tong, Ziruo Huang, Yunzhi Chen   +7 more
doaj   +1 more source

Polymeric Approaches to Reduce Tissue Responses Against Devices Applied for Islet-Cell Encapsulation

Frontiers in Bioengineering and Biotechnology, 2019
Immunoisolation of pancreatic islets is a technology in which islets are encapsulated in semipermeable but immunoprotective polymeric membranes.
Shuixan Hu, Paul de Vos
doaj   +1 more source

Possible role of endogenous prostaglandins in glucagon secretion by isolated guinea-pig islets [PDF]

, 1978
A Luyckx, Pierre J. Lefèbvre
openalex   +1 more source