Results 101 to 110 of about 10,923 (183)

Fatty acids alter to the toxicity of islet amyloid polypeptide aggregates in a length and saturation dependent manner. [PDF]

iScience
Sitton J, Pickett D, Hung A, Elsaigh R, Kurouski D.   +4 more
europepmc   +1 more source

Contribution of the 12-17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity. [PDF]

Front Mol Biosci, 2022
Fortier M, Côté-Cyr M, Nguyen V, Babych M, Nguyen PT, Gaudreault R, Bourgault S.   +6 more
europepmc   +1 more source

Experimental and computational analysis of the basis for accelerated amyloid formation by a disease linked mutant of human islet amyloid polypeptide. [PDF]

Protein Sci
Manathunga L, Akter R, Zou J, Simmerling C, Raleigh DP.   +4 more
europepmc   +1 more source

Molecular Mechanisms of Islet Amyloid Polypeptide Aggregation: Towards Chemical Strategies to Prevent Amyloid Formation and to Design Non-Aggregating Peptide Therapeutics. [PDF]

Int J Mol Sci
Bousch C, Bérubé F, Babych M, Ongeri S, Bourgault S.   +4 more
europepmc   +1 more source

On the plasticity of amyloid formation: The impact of destabilizing small to large substitutions on islet amyloid polypeptide amyloid formation. [PDF]

Protein Sci, 2023
Manathunga L, Akter R, Zhyvoloup A, Simmerling C, Raleigh DP.   +4 more
europepmc   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co-Oligomerized with β-Amyloid 1-42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids. [PDF]

Adv Sci (Weinh)
Yan J, Tang Z, Luo Y, Liu B, Huang X, Wei J, Yue F.   +6 more
europepmc   +1 more source

Fibril elongation by human islet amyloid polypeptide is the main event linking aggregation to membrane damage. [PDF]

BBA Adv, 2023
Elenbaas BOW, Kremsreiter SM, Khemtemourian L, Killian JA, Sinnige T.   +4 more
europepmc   +1 more source

Chemical synthesis uncovers the significant impact of natural glycosylation on islet amyloid polypeptide aggregation. [PDF]

Sci Adv
Li Y, Liu W, Wang R, Liu D, Li X, Zhang C, Gong J, Song Z, Zhang Y, Tan Z.   +9 more
europepmc   +1 more source

Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding. [PDF]

J Am Soc Mass Spectrom, 2023
Sanders HM, Chalyavi F, Fields CR, Kostelic MM, Li MH, Raleigh DP, Zanni MT, Marty MT.   +7 more
europepmc   +1 more source

Human Islet Amyloid Polypeptide (hIAPP) Protofibril-Specific Antibodies for Detection and Treatment of Type 2 Diabetes. [PDF]

Adv Sci (Weinh), 2022
Bortoletto AS, Graham WV, Trout G, Bonito-Oliva A, Kazmi MA, Gong J, Weyburne E, Houser BL, Sakmar TP, Parchem RJ.   +9 more
europepmc   +1 more source