Results 71 to 80 of about 10,923 (183)

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun, Linqing Wen, Shiyun Tang, Lu Liu, Nianzhi Chen   +4 more
wiley   +1 more source

Polyphenol Interactions with Amyloid Fibrils: A Molecular Docking Study

East European Journal of Physics
Polyphenols, a versatile group of naturally occurring compounds with many favorable biological properties currently attract increasing research interest in the context of their ability to inhibit the formation and to destabilize special protein ...
Uliana Malovytsia, Valeriya Trusova, Mette Thomsen, Kateryna Vus, Olga Zhytniakivska, Galyna Gorbenko   +5 more
doaj   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

Membrane-mediated amyloid deposition of human islet amyloid polypeptide [PDF]

Biophysical Reviews, 2017
Amyloid deposition of human islet amyloid polypeptide (hIAPP) within the islet of Langerhans is closely associated with type II diabetes mellitus. Accumulating evidence indicates that the membrane-mediated aggregation and subsequent deposition of hIAPP are linked to the dysfunction and death of insulin-producing pancreatic β-cells, but the molecular ...
openaire   +2 more sources

Porcine islet amyloid polypeptide fragments are refractory to amyloid formation

FEBS Letters, 2010
Of 10 variation sites between sequences of amyloid-resistant porcine islet amyloid polypeptide (pIAPP) and amyloid-prone human IAPP (hIAPP), seven locate within residues 17-29, the most amyloidogenic fragment within hIAPP. To investigate how these variations affect amyloidogenicity, 26 IAPP(17-29) or IAPP(20-29) variants were synthesized and their ...
Zhang, Xin, Cheng, Biao, Gong, Hao, Li, Chuanzhou, Chen, Hong, Zheng, Ling, Huang, Kun   +6 more
openaire   +4 more sources

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

Molecular Neurodegeneration, 2007
Background Amyloid-related degenerative diseases are associated with the accumulation of misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid accumulates in several distinct types of insoluble plaque deposits, intracellular
Rasool Suhail, Thompson Jennifer L, Breydo Leonid, Wu Jessica, Margol Lawrence, Necula Mihaela, Cotman Carl W, Saing Tommy, Sarsoza Floyd, Head Elizabeth, Kayed Rakez, Gurlo Tatyana, Butler Peter, Glabe Charles G   +13 more
doaj   +1 more source

Pancreatic β cell–selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis

JCI Insight, 2021
GWAS have shown that the common R325W variant of SLC30A8 (ZnT8) increases the risk of type 2 diabetes (T2D). However, ZnT8 haploinsufficiency is protective against T2D in humans, counterintuitive to earlier work in humans and mouse models.
Jie Xu, Nadeeja Wijesekara, Romario Regeenes, Dana Al Rijjal, Anthony L. Piro, Youchen Song, Anne Wu, Alpana Bhattacharjee, Ying Liu, Lucy Marzban, Jonathan V. Rocheleau, Paul E. Fraser, Feihan F. Dai, Cheng Hu, Michael B. Wheeler   +14 more
doaj   +1 more source

Treatment of T2DM-related inflammation and vascular injury by regulating cellular crosstalk in the islet microenvironment

Frontiers in Endocrinology
Type 2 diabetes mellitus (T2DM), a complex systemic metabolic disorder caused by multiple factors, has been linked to numerous acute and chronic complications.
Aru Sun, Aru Sun, Haoyu Yang, Jun Sun, Jinli Luo, Ling Zhou, Tingting Bao, Xiaolin Tong, Yiqun Lin, Lin Han   +9 more
doaj   +1 more source

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

eLife, 2016
Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and biological measurements, we define the toxic species produced during IAPP ...
Andisheh Abedini, Annette Plesner, Ping Cao, Zachary Ridgway, Jinghua Zhang, Ling-Hsien Tu, Chris T Middleton, Brian Chao, Daniel J Sartori, Fanling Meng, Hui Wang, Amy G Wong, Martin T Zanni, C Bruce Verchere, Daniel P Raleigh, Ann Marie Schmidt   +15 more
doaj   +1 more source