A pancreatic player in dementia: pathological role for islet amyloid polypeptide accumulation in the brain. [PDF]
Neural Regen Res, 2023 Type 2 diabetes mellitus patients have a markedly higher risk of developing dementia. While multiple factors contribute to this predisposition, one of these involves the increased secretion of amylin, or islet amyloid polypeptide, that accompanies the ...
Bortoletto AS, Parchem RJ.
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Islet amyloid polypeptide does not suppress pancreatic cancer [PDF]
Molecular Metabolism, 2023 Objectives: Pancreatic cancer risk is elevated approximately two-fold in type 1 and type 2 diabetes. Islet amyloid polypeptide (IAPP) is an abundant beta-cell peptide hormone that declines with diabetes progression.
Austin J. Taylor +7 more
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The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer's diseases. [PDF]
Diabetol Metab Syndr, 2023 Human Islet amyloid polypeptide (hIAPP) from pancreatic β cells in the islet of Langerhans has different physiological functions including inhibiting the release of insulin and glucagon.
Alrouji M +6 more
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General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. [PDF]
PLoS ONE, 2014 Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to contribute to the progression of type 2 diabetes and to the failure of islet transplants.
Hui Wang, Daniel P Raleigh
doaj +10 more sources
Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease. [PDF]
Mol Neurodegener, 2022 Background The pathologic accumulation and aggregation of tau is a hallmark of tauopathies including Alzheimer’s disease (AD). However, the molecular mechanisms mediating tau aggregation in AD remain elusive.
Zhang G +6 more
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Chemical Reviews, 2021 The possible link between hIAPP accumulation and β-cell death in diabetic patients has inspired numerous studies focusing on amyloid structures and aggregation pathways of this hormone.
Danilo Milardi +2 more
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Studies on alpha-synuclein and islet amyloid polypeptide interaction [PDF]
Frontiers in Molecular Biosciences, 2023 Introduction: Parkinson’s disease and type 2 diabetes have both elements of local amyloid depositions in their pathogenesis. In Parkinson’s disease, alpha-synuclein (aSyn) forms insoluble Lewy bodies and Lewy neurites in brain neurons, and in type 2 ...
Ye Wang +5 more
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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers [PDF]
Molecular Neurodegeneration, 2007 Background Amyloid-related degenerative diseases are associated with the accumulation of misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid accumulates in several distinct types of insoluble plaque deposits, intracellular
Rasool Suhail +13 more
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Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics [PDF]
eLife, 2016 Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and biological measurements, we define the toxic species produced during IAPP ...
Andisheh Abedini +15 more
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The Effect of Cholesterol on Membrane-Bound Islet Amyloid Polypeptide [PDF]
Frontiers in Molecular Biosciences, 2021 Islet amyloid polypeptide (IAPP) is a proposed cause of the decreased beta-cell mass in patients with type-II diabetes. The molecular composition of the cell-membrane is important for regulating IAPP cytotoxicity and aggregation.
Mikkel Christensen +5 more
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