Results 91 to 100 of about 20,996 (256)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Molecular Mechanisms of Amylin Turnover, Misfolding and Toxicity in the Pancreas

Molecules, 2022
Amyloidosis is a common pathological event in which proteins self-assemble into misfolded soluble and insoluble molecular forms, oligomers and fibrils that are often toxic to cells.
Diti Chatterjee Bhowmick, Zhanar Kudaibergenova, Lydia Burnett, Aleksandar M. Jeremic   +3 more
doaj   +1 more source

Identification of a hinge residue controlling islet amyloid polypeptide self-assembly and cytotoxicity

Journal of Biological Chemistry, 2019
The islet amyloid polypeptide (IAPP) is a 37-residue peptide hormone whose deposition as amyloid fibrils in the pancreatic islets is associated with type 2 diabetes.
Elizabeth Godin, P. T. Nguyen, Ximena Zottig, Steve Bourgault   +3 more
semanticscholar   +1 more source

Autoantibodies to Islet Amyloid Polypeptide in Diabetes

Diabetic Medicine, 1991
Islet amyloid polypeptide (IAPP) is the constituent peptide of amyloid in pancreatic islets of Type 2 diabetic patients and in insulinomas. Amyloid formation in Type 2 diabetes is associated with islet cell destruction which may promote formation of autoantibodies to IAPP.
Clark, A, Yon, S, de Koning, E, Holman, R   +3 more
openaire   +3 more sources

Mechanistic Role of Disulfidptosis in Type 2 Diabetes Mellitus

Molecular Nutrition &Food Research, Volume 70, Issue 4, 26 February 2026.
This study elucidates the potential link between disulfidptosis and type 2 diabetes mellitus (T2DM). We propose that high SLC7A11 expression combined with glucose starvation triggers rapid NADPH depletion and severe disulfide stress. This leads to aberrant disulfide cross‐linking of actin cytoskeletal proteins and F‐actin network collapse, inducing ...
Danqi Zou, Yanping Zou, Yujie Jin, Shilin Liu, Minghao Lin, Ruixue Deng, Zheng Nan   +6 more
wiley   +1 more source

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang   +12 more
wiley   +1 more source

The role of copper(II) in the aggregation of human amylin [PDF]

, 2014
Amylin is the 37-residue peptide hormone produced by the islet β-cells in the pancreas and the formation of amylin aggregates is strongly associated with β-cells degeneration in type 2 diabetes, as demonstrated by more than 95% of patients exhibiting ...
Alessandro Sinopoli, Alexandrescu, Angela Flagiello, Antonio Magrì, Aston-Mourney, Bellia, Bellia, Bennett, Brender, Cao, Cao, Cheng, Cheng, Chien, Ciaccio, Danilo Milardi, De Toma, Dupuis, Fu, Giuffrida, Giuseppe Caruso, Giuseppe Grasso, Giuseppe Pappalardo, Grasso, Grasso, Grasso, Grasso, Grasso, Guan, Guo, House, Jeremy J. Titman, Jha, Kamihira-Ishijima, Kim, Konarkowska, Kállay, Lemaire, Madine, Masad, Matteo Pappalardo, Mirhashemi, Pannuzzo, Pappalardo, Phillips, Pietro Pucci, Ralat, Sciacca, Sedman, Shen, Tu, Vincenzo Giuseppe Nicoletti, Ward, Westermark, Westermark, Williams, Yu, Yu   +57 more
core   +2 more sources

Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review

BioFactors, Volume 52, Issue 1, January/February 2026.
Resveratrol induces the expressions of TP53, NRF2, and JDP2 axis in cancer cells to control ROS balance in mitochondria. The antioxidation responses were induced through SRIT1/3, HDAC, STAT3, TGFβ, and so on, to trigger the inflammation, and NFkB response to lead to the cell death of cancers or neuro‐damaged cells.
Kenly Wuputra, Chia‐Che Ku, Ying‐Chu Lin, Yi‐Chun Tsai, Deng‐Chyang Wu, Yukio Mitsui, Maki Satou, Yuuki Tanaka, Shigeo Saito, Kazunari K. Yokoyama   +9 more
wiley   +1 more source

Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate. [PDF]

PLoS ONE, 2016
Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose homeostasis.
Ingrid C Rulifson, Ping Cao, Li Miao, David Kopecky, Linda Huang, Ryan D White, Kim Samayoa, Jonitha Gardner, Xiaosu Wu, Kui Chen, Trace Tsuruda, Oliver Homann, Helene Baribault, Harvey Yamane, Tim Carlson, Jed Wiltzius, Yang Li   +16 more
doaj   +1 more source

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes. [PDF]

, 2019
BackgroundMyriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) - a condition referred to as "ER stress" - activate intracellular signaling pathways termed the unfolded ...
Colon-Negron, Kevin, Ghosh, Rajarshi, Papa, Feroz R   +2 more
core   +1 more source