Results 121 to 130 of about 20,996 (256)

Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations

MedComm, Volume 6, Issue 12, December 2025.
Along with organismal aging or pathogenic processes especially tumor, multiple immune cell types exhibit those well‐established hallmarks of cellular senescent phenotype, mainly characterized by irreversible cell cycle arrest, metabolic disorder, and over production of SASP.
Ninghan Gong, Xiting Pan, Yusi Deng, Jiajia Che, Junhao Bao, Mengqi Wang, Chuan Xu, Xiaowei Liu, Ying Shi   +8 more
wiley   +1 more source

Simvastatin Rapidly and Reversibly Inhibits Insulin Secretion in Intact Single-Islet Cultures [PDF]

, 2016
open10Epidemiological studies suggest that statins may promote the development or exacerbation of diabetes, but whether this occurs through inhibition of insulin secretion is unclear.
Alessandro Zambon, Angelo Avogaro, Camilla Luni, Catalin Dacian Ciubotaru, Fabio Mammano, Gian Paolo Fadini, Nicola Elvassore, Onelia Gagliano, Silvia Galvanin, Valentina Scattolini   +9 more
core   +2 more sources

Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

Diabetes, 2008
OBJECTIVE—Islet amyloid, formed by aggregation of the β-cell peptide islet amyloid polypeptide (IAPP; amylin), is a pathological characteristic of pancreatic islets in type 2 diabetes.
L. Marzban, Alejandra Tomas, T. Becker, L. Rosenberg, J. Oberholzer, P. Fraser, P. Halban, C. Verchere   +7 more
semanticscholar   +1 more source

Characterization of Cytokine Treatment on Human Pancreatic Islets by Top‐Down Proteomics

PROTEOMICS, Volume 25, Issue 24, Page 55-66, December 2025.
ABSTRACT Type 1 diabetes (T1D) results from autoimmune‐mediated destruction of insulin‐producing β cells in the pancreatic islet. This process is modulated by pro‐inflammatory cytokine signaling, which has been previously shown to alter protein expression in ex vivo islets.
Ashley N. Ives, Tyler J. Sagendorf, Lorenz Nierves, Tai‐Tu Lin, Ercument Dirice, Rohit N. Kulkarni, Ljiljana Paša‐Tolić, Wei‐Jun Qian, James M. Fulcher   +8 more
wiley   +1 more source

Electrochemical Assay of Human Islet Amyloid Polypeptide and Its Aggregation

Sensors, 2008
Square wave voltammetry is used in this work to detect human islet amyloid polypeptide (hIAPP) by using the oxidized signal of the tyrosine residue in hIAPP. A detection limit of 1×10-6 M for hIAPP has been obtained. A kinetic study of the aggregation
Genxi Li, Dongmei Zhang, Zhenyu Chen, Nandi Zhou   +3 more
doaj   +1 more source

Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity [PDF]

, 2015
The nuclear factor κB (NF-κB) pathway is a master regulator of inflammatory processes and is implicated in insulin resistance and pancreatic β cell dysfunction in the metabolic syndrome.
Brink, Robert, Cantley, James, Grey, Shane T., Hesselson, Daniel, Koay, Yen Chin, Loudovaris, Tom, Malle, Elisabeth K., McAlpine, Shelli R., Tan, Bernice M., Villanueva, Jeanette E., Walters, Stacey N., Wu, Jianmin, Zammit, Nathan W.   +12 more
core   +4 more sources

Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein.

Biochimica et Biophysica Acta - Biomembranes, 2018
Protein aggregation is a ubiquitous phenomenon underpinning the origins of a range of human diseases. The amyloid aggregation of human islet amyloid polypeptide (IAPP) and alpha synuclein (αS), specifically, is a hallmark of type 2 diabetes (T2D) and ...
Aleksandr Kakinen, I. Javed, Ava Faridi, T. P. Davis, P. Ke   +4 more
semanticscholar   +1 more source

Amylin Revisited: A 5-Year Perspective on Its Emerging Role in the Treatment of Diabesity

Journal of Obesity & Metabolic Syndrome
Amylin is a pancreatic peptide hormone that regulates blood glucose levels and appetite. This review outlines the physiological role of amylin and highlights recent clinical studies exploring its therapeutic potential in diabetes and obesity.
Chae Won Chung, Jaetaek Kim
doaj   +1 more source

Histological insights into the pathogenesis of post‐Roux‐en‐Y hyperinsulinaemic hypoglycaemia [PDF]

, 2014
Background β‐cell hyperplasia has been implicated in the aetiology of post Roux‐en‐Y gastric bypass hyperinsulinaemic hypoglycaemia, but the pathogenesis of this condition is still unclear. Case report We report a case of a 52‐year‐old man with post‐
Giordano, T. J., Hodish, I., Lash, R. W., Moraitis, A. G.   +3 more
core   +1 more source

Star Polymers Reduce Islet Amyloid Polypeptide Toxicity via Accelerated Amyloid Aggregation

Biomacromolecules, 2017
Protein aggregation into amyloid fibrils is a ubiquitous phenomenon across the spectrum of neurodegenerative disorders and type 2 diabetes. A common strategy against amyloidogenesis is to minimize the populations of toxic oligomers and protofibrils by ...
Emily H. Pilkington, M. Lai, Xinwei Ge, William J. Stanley, Bo Wang, Miaoyi Wang, Aleksandr Kakinen, M. Sani, M. Whittaker, E. N. Gurzov, Feng Ding, J. Quinn, T. P. Davis, P. Ke   +13 more
semanticscholar   +1 more source