Results 141 to 150 of about 20,996 (256)
Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. [PDF]
, 2019 Amyloid-β (Aβ) harbors numerous posttranslational modifications (PTMs) that may affect Alzheimer's disease (AD) pathogenesis. Here we present the 1.1 Å resolution MicroED structure of an Aβ 20-34 fibril with and without the disease-associated PTM, L ...
Boyer, David R +8 more
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Islet amyloid polypeptide in pancreatic islets from type 2 diabetic subjects [PDF]
Islets, 2012 Islet amyloid polypeptide (IAPP) is a chief constituent of amyloid deposits in pancreatic islets, characteristic histopathology for type 2 diabetes. The goal of this study was to analyze islet cell composition in diabetic islets for the process of transforming water-soluble IAPP in β-cells to water-insoluble amyloid deposits by Immunocytochemical ...
openaire +2 more sources
A Novel Pentapeptide Inhibitor Reduces Amyloid Deposit Formation by Direct Interaction with hIAPP
International Journal of Endocrinology, 2019 Backgrounds. The presence of amyloid deposits of human islet amyloid polypeptide (hIAPP) in islet β-cells has been associated with type 2 diabetes occurrence and islet graft failure.
Yue Shi +4 more
doaj +1 more source
Upsala Journal of Medical Sciences, 2017 Background: Enhanced IAPP production may contribute to islet amyloid formation in type 2 diabetes. The objective of this study was to determine the effects of the saturated fatty acid palmitate on IAPP levels in human β-cells.
Camilla Krizhanovskii +4 more
doaj +1 more source
Human insulinoma: Clinical, cellular, and molecular aspects [PDF]
, 2018 Insulinoma is the most frequently encountered functioning endocrine pancreatic tumor in humans. In this overview we summarize morphological and clinical features of insulinomas, report about the proinsulin-insulin conversion in normal and neoplastic B ...
Heitz, Philipp +2 more
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Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21st Century [PDF]
, 2015 The amyloid precursor protein (APP) is mainly known for being the precursor of the ß-amyloid peptide, which accumulates in plaques found in the brain of Alzheimer's disease patients.
Franco Fernández, Rafael +3 more
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A small molecule improves diabetes in mice expressing human islet amyloid polypeptide. [PDF]
Islets, 2023 Bhagat V, Verchere CB.
europepmc +1 more source
In silico studies on potential binding sites of amyloid inhibitor compounds on amyloid beta peptide [PDF]
, 2012 The formation of structurally similar insoluble fibrillar protein aggregates, called amyloids, is known to cause several neuronal and non-neuronal degenerative diseases such as Alzheimer‟s disease, Parkinson‟s disease, Huntington‟s disease and Diabetes ...
Rudra, Sumon
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Clinical Interventions in Aging, 2015 Hye Rin Jeong, Seong Soo A AnDepartment of Bionano Technology, Gachon Medical Research Institute, Gachon University, Gyeonggi-do, Republic of KoreaAbstract: Human islet amyloid polypeptide (h-IAPP) is a peptide hormone that is synthesized and cosecreted ...
Jeong HR, An SSA
doaj