Results 31 to 40 of about 20,996 (256)

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. [PDF]

, 2010
ObjectiveThe islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP).
Butler, Alexandra E, Butler, Peter C, Costes, Safia, Daval, Marie, Gurlo, Tatyana, Huang, Chang-jiang, Matveyenko, Aleksey V, Rizza, Robert A   +7 more
core   +2 more sources

The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities. [PDF]

, 2020
Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2 diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue and liver inflammation have been particularly well studied; however ...
Fu, Wenxian, Lee, Yun Sok, Olefsky, Jerrold M, Ying, Wei   +3 more
core   +2 more sources

Islet Amyloid Polypeptide: A Partner in Crime With Aβ in the Pathology of Alzheimer's Disease

Frontiers in Molecular Neuroscience, 2020
Diabetes affects hundreds of millions of patients worldwide. Despite the advances in understanding the disease and therapeutic options, it remains a leading cause of death and of comorbidities globally.
A. Raimundo, Sofia Ferreira, I. C. Martins, Regina Menezes   +3 more
semanticscholar   +1 more source

High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus. [PDF]

PLoS ONE, 2014
Aims/hypothesisIslet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid ...
Johan F Paulsson, Johnny Ludvigsson, Annelie Carlsson, Rosaura Casas, Gun Forsander, Sten A Ivarsson, Ingrid Kockum, Åke Lernmark, Claude Marcus, Bengt Lindblad, Gunilla T Westermark   +10 more
doaj   +1 more source

Inhibition of human islet amyloid polypeptide aggregation and cellular toxicity by oleuropein and derivatives from olive oil.

International Journal of Biological Macromolecules, 2020
Loss of β-cell function and β-cell death is the key feature of type 2 diabetes mellitus (T2DM). One hypothesis for the mechanism of this feature is amyloid formation by the human islet amyloid polypeptide (hIAPP).
Ali Chaari
semanticscholar   +1 more source

Type 2 diabetes mellitus as a prion disease (literature review)

Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2022
Type 2 diabetes mellitus (T2DM) is the most common endocrine disease characterized by impaired insulin, hyperglycemia and chronic insulin resistance due to dysfunction and loss of β-cells of the islets of Largenhans.
A.S. Filimonova, D.S. Mar'evskaya, T.V. Ulanova, L.N. Komarova   +3 more
doaj   +1 more source

Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding. [PDF]

J Am Soc Mass Spectrom, 2023
The aggregation of islet amyloid polypeptide (IAPP) is associated with β-cell dysfunction in type 2 diabetes (T2D) in humans. One possible mechanism of toxicity is the interaction of IAPP oligomers with lipid membranes to disrupt the bilayer integrity and/or homeostasis of the cell.
Sanders HM, Chalyavi F, Fields CR, Kostelic MM, Li MH, Raleigh DP, Zanni MT, Marty MT.   +7 more
europepmc   +3 more sources

β-Cell failure in type 2 diabetes: a case of asking too much of too few? [PDF]

, 2013
The islet in type 2 diabetes (T2DM) is characterized by a deficit in β-cells, increased β-cell apoptosis, and extracellular amyloid deposits derived from islet amyloid polypeptide (IAPP). In the absence of longitudinal studies, it is unknown if the low β-
Butler, Peter C, Costes, Safia, Gurlo, Tatyana, Langen, Ralf, Matveyenko, Aleksey V   +4 more
core   +1 more source

Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide [PDF]

, 2016
Many chronic degenerative diseases result from aggregation of misfolded polypeptides to form amyloids. Many amyloidogenic polypeptides are surfactants and their assembly can be catalysed by hydrophobic-hydrophilic interfaces (an air-water interface in ...
Hawkins, N, Hodder, P, Jean, L, Lee, CF, Vaux, DJ   +4 more
core   +1 more source

IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

Nature Communications, 2019
Type 2 diabetes is associated with islet amyloid deposits derived from islet amyloid polypeptide (IAPP) expressed by β-cells. Here the authors show that IAPP misfolded protein stress induces the hypoxia inducible factor 1 alpha injury repair pathway and ...
Chiara Montemurro, Hiroshi Nomoto, Lina Pei, Vishal S. Parekh, Kenny E. Vongbunyong, Suryakiran Vadrevu, Tatyana Gurlo, Alexandra E. Butler, Rohan Subramaniam, Eleni Ritou, Orian S. Shirihai, Leslie S. Satin, Peter C. Butler, Slavica Tudzarova   +13 more
doaj   +1 more source