Results 51 to 60 of about 20,996 (256)
Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation
Biomolecules, 2021 Amyloid-formation by the islet amyloid polypeptide (IAPP), produced by the β-cells in the human pancreas, has been associated with the development of type II diabetes mellitus (T2DM).
Sanduni Wasana Jayaweera +7 more
doaj +1 more source
Decreased islet amyloid polypeptide staining in the islets of insulinoma patients. [PDF]
IsletsIslet amyloid polypeptide (IAPP) is a factor that regulates food intake and is secreted from both pancreatic islets and insulinoma cells. Here, we aimed to evaluate IAPP immunohistochemically in islets or insulinoma cells in association with clinical characteristics.
Ishibashi C +10 more
europepmc +3 more sources
Data in Brief, 2016 Protein misfolding and aggregation are responsible for a large number of diseases called protein conformational diseases or disorders that include Alzheimer׳s disease, Huntington׳s diseases, Prion related encephalopathies and type-II diabetes (http://dx ...
Mohammed Inayathullah, Jayakumar Rajadas
doaj +1 more source
Prediction of "hot spots" of aggregation in disease-linked polypeptides [PDF]
, 2005 Background: The polypeptides involved in amyloidogenesis may be globular proteins with a defined 3D-structure or natively unfolded proteins. The first class includes polypeptides such as β2-microglobulin, lysozyme, transthyretin or the prion protein ...
Sánchez de Groot, Natalia +4 more
core +1 more source
Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses
Frontiers in Immunology, 2020 Amyloid deposition is a histological hallmark of common human disorders including Alzheimer's disease (AD) and type 2 diabetes. Although some reports highlight that amyloid fibrils might activate the innate immunity system via pattern recognition ...
Yan-Mei Huang +14 more
doaj +1 more source
Neural Regeneration Research, 2021 Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent ...
Sofia Ferreira +3 more
doaj +1 more source
Pancreatic cancer-associated diabetes mellitus: an open field for proteomic applications. [PDF]
, 2005 Background: Diabetes mellitus is associated with pancreatic cancer in more than 80% of the cases. Clinical, epidemiological, and experimental data indicate that pancreatic cancer causes diabetes mellitus by releasing soluble mediators which interfere ...
BALDO G +11 more
core +1 more source
Islet amyloid polypeptide toxicity and membrane interactions [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance Amyloid formation is a hallmark of a range of human diseases. The polypeptide hormone amylin forms amyloid deposits in type 2 diabetes, and amyloid formation is thought to be a contributor to the decline in β-cell mass in the disease, however the basis of amylin-induced cytotoxicity is not fully understood.
Cao, Ping +6 more
openaire +4 more sources
Molecular Metabolism, 2017 Objectives: β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis of type 2 diabetes (T2D). Growing evidence suggests that islet amyloid, formed by aggregation of human islet amyloid polypeptide (hIAPP ...
Queenie Hui +6 more
doaj +1 more source
Scientific Reports, 2021 Amyloid deposits in pancreatic islets, mainly formed by human islet amyloid polypeptide (hIAPP) aggregation, have been associated with loss of β-cell mass and function, and are a pathological hallmark of type 2 diabetes (T2D).
Sara de Pablo +9 more
doaj +1 more source