Results 61 to 70 of about 20,996 (256)

Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation [PDF]

, 2016
Human Amylin, or islet amyloid polypeptide (hIAPP), is a small hormone secreted by pancreatic-cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus.
Carrodeguas Villar, José Alberto, López Rodríguez, Laura Catalina, Navarro, Susanna, Sancho Sanz, Javier, Sánchez de Groot, Natalia, Varea, Olga, Ventura, Salvador   +6 more
core   +3 more sources

Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide

Frontiers in Molecular Biosciences, 2023
Insulin resistance is the major risk factor for Type 2 diabetes (T2D). In vulnerable individuals, insulin resistance induces a progressive loss of insulin secretion with islet pathology revealing a partial deficit of beta cells and islet amyloid derived ...
Tatyana Gurlo, Thazha P. Prakash, Zhongying Wang, Maani Archang, Lina Pei, Madeline Rosenberger, Elaine Pirie, Richard G. Lee, Peter C. Butler   +8 more
doaj   +1 more source

Role of the fast kinetics of pyroglutamate-modified amyloid-β oligomers in membrane binding and membrane permeability. [PDF]

, 2014
Membrane permeability to ions and small molecules is believed to be a critical step in the pathology of Alzheimer's disease (AD). Interactions of oligomers formed by amyloid-β (Aβ) peptides with the plasma cell membrane are believed to play a fundamental
Gillman, Alan L, Jang, Hyunbum, Kagan, Bruce L, Lee, Joon, Nussinov, Ruth, Ramachandran, Srinivasan, Teran Arce, Fernando   +6 more
core   +1 more source

Membrane interaction of islet amyloid polypeptide

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
Increasing evidence suggests that the misfolding and deposition of IAPP plays an important role in the pathogenesis of type II, or non-insulin-dependent diabetes mellitus (T2DM). Membranes have been implicated in IAPP-dependent toxicity in several ways: Lipid membranes have been shown to promote the misfolding and aggregation of IAPP. Thus, potentially
Jayasinghe, Sajith A., Langen, Ralf
openaire   +2 more sources

Amyloid-Mediated Mechanisms of Membrane Disruption

Biophysica, 2021
Protein aggregation and amyloid formation are pathogenic events underlying the development of an increasingly large number of human diseases named “proteinopathies”.
Michele F. M. Sciacca, Carmelo La Rosa, Danilo Milardi   +2 more
doaj   +1 more source

Insulin secretory granules labelled with phogrin-fluorescent proteins show alterations in size, mobility and responsiveness to glucose stimulation in living β-cells [PDF]

, 2019
The intracellular life of insulin secretory granules (ISGs) from biogenesis to secretion depends on their structural (e.g. size) and dynamic (e.g. diffusivity, mode of motion) properties.
Bugliani, Marco, Cappello, Valentina, Caracciolo, Giulio, Cardarelli, Francesco, Digiacomo, Luca, Ferri, Gianmarco, Lavagnino, Zeno, Marchetti, Piero, Occhipinti, Margherita, Piston, David W.   +9 more
core   +3 more sources

Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation [PDF]

Proceedings of the National Academy of Sciences, 2017
SignificanceProtein assembly into amyloid fibers underlies such neurodegenerative disorders as Alzheimer’s disease and Parkinson’s disease. Type 2 diabetes (T2D) also involves amyloid formation, although in the pancreas. Because there are no cures for amyloid diseases and T2D is on the rise due to an increasing prevalence of obesity, identifying ...
Diana Ribeiro, Istvan Horvath, Nikki Heath, Ryan Hicks, Anna Forslöw, Pernilla Wittung-Stafshede   +5 more
openaire   +3 more sources

Nucleation of β-rich oligomers and β-barrels in the early aggregation of human islet amyloid polypeptide.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2019
The self-assembly of human islet amyloid polypeptide (hIAPP) into β-sheet rich amyloid aggregates is associated with pancreatic β-cell death in type 2 diabetes (T2D).
Yunxiang Sun, Aleksandr Kakinen, Yanting Xing, Emily H. Pilkington, T. P. Davis, P. Ke, Feng Ding   +6 more
semanticscholar   +1 more source

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. [PDF]

, 2008
Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (Abeta) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 ...
Bosman, F., Darbinian-Sarlissian, N., Khalili, K., Kis, A., Làszló, F., Martins, R.N., McGeer, P.L., Miklossy, J., Miller, L., Mooser, V., Qing, H., Radenovic, A., Vileno, B., Waeber, G.   +13 more
core   +2 more sources

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source