Results 91 to 100 of about 39,685 (253)

Classification of microscopy images of Langerhans islets [PDF]

, 2014
Evaluation of images of Langerhans islets is a crucial procedure for planning an islet transplantation, which is a promising diabetes treatment. This paper deals with segmentation of microscopy images of Langerhans islets and evaluation of islet ...
Berková, Zuzana, Girman, Peter, Habart, David, Kybic, Jan, Kříž, Jan, Zacharovová, Klára, Švihlík, Jan   +6 more
core   +1 more source

The Endothelial Cells in Islets of Langerhans [PDF]

Upsala Journal of Medical Sciences, 2005
The blood vessels of the pancreatic islets are of crucial importance for oxygen and metabolite supply, and dispersal of secreted hormones. In addition to this, endothelial cells have an important role in the revascularization process after islet transplantation.
openaire   +3 more sources

Characterization of the Pancreatic Neuroendocrine Neoplasm Immune Microenvironment

Cancer Medicine, Volume 14, Issue 7, April 2025.
Enhancements in the creation of animal models that most accurately represent the aggressive types of pancreatic neuroendocrine neoplasms are necessary to create therapeutic protocols that combine immunotherapies with other medication classes to help patients with metastatic disease recover or respond to treatment more durably. Tumor microenvironment is
Filipe Reis Neves, Ana Luís Martins, Rui Caetano Oliveira, Rui Martins   +3 more
wiley   +1 more source

Immunological characterization of chromogranins A and B and secretogranin II in the bovine pancreatic islet [PDF]

, 1987
Antisera against chromogranin A and B and secretogranin II were used for analysing the bovine pancreas by immunoblotting and immunohistochemistry. All three antigens were found in extracts of fetal pancreas by one dimensional immunoblotting. A comparison
A Iacangelo, AD Smith, BS Wilson, C Hagn, D Grube, D Grube, D Grube, DT O'Connor, DT O'Connor, DV Cohn, E El-Nady, FU Reiffen, FU Reiffen, G Falkensammer, G Falkensammer, G Rindi, H Blaschko, H Lassmann, H Winkler, HD Mayor, IM Varndell, JA Nolan, JC Hutton, K Tatemoto, KB Helle, KB Helle, L Kilpatrick, LA Sternberger, LE Eiden, M Ehrhart, M Ravazzola, P Rosa, PH O'Farell, R Fischer-Colbrie, R Fischer-Colbrie, R Fischer-Colbrie, R Fischer-Colbrie, RV Floyd, S Bonner-Weir, S Lenzen, UK Laemmli, UM Benedum, WB Huttner, WJ Smith, WN Burnette   +44 more
core   +1 more source

Membrane permeabilization by Islet Amyloid Polypeptide

, 2009
Membrane permeabilization by Islet Amyloid Polypeptide (IAPP) is suggested to be the main mechanism for IAPP-induced cytotoxicity and death of insulin-producing -cells in type 2 diabetes mellitus (T2DM).
Engel, Maarten F.M.
core   +1 more source

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
DJ Garry, GF Bottazzo, GF Bottazzo, GS Eisenbarth, J Satoh, MA Atkinson, MR Christie, P Casali, PG Colman, R Gianani, RC Nayak, RJ Tuson, RL Sorenson, S Baekkeskov, S Baekkeskov, S Genovese, W Richter, W Richter, W Richter, WA Scherbaum   +19 more
core   +1 more source

Adventures with Insulin in the Islets of Langerhans [PDF]

Journal of Biological Chemistry, 2011
Insulin is a small but beautifully organized protein with a unique two-chain structure, the first protein to be sequenced. The mechanism of its biosynthesis invited much initial speculation but was finally clarified by the discovery of proinsulin, its single-chain precursor.
openaire   +3 more sources

Simvastatin Rapidly and Reversibly Inhibits Insulin Secretion in Intact Single-Islet Cultures [PDF]

, 2016
open10Epidemiological studies suggest that statins may promote the development or exacerbation of diabetes, but whether this occurs through inhibition of insulin secretion is unclear.
Alessandro Zambon, Angelo Avogaro, Camilla Luni, Catalin Dacian Ciubotaru, Fabio Mammano, Gian Paolo Fadini, Nicola Elvassore, Onelia Gagliano, Silvia Galvanin, Valentina Scattolini   +9 more
core   +2 more sources

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]

, 2016
Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez, Achenbach, Adelstein, Akashi, Batista, Bodansky, Cooke, Crotty, Dean, Emil R. Unanue, Ferris, Gagnerault, Garside, Gitlin, Glazier, Goodnow, Greeley, Gretz, Harbers, Henry, Henry, Henry-Bonami, Hoppu, Hu, Hulbert, Höglund, James W. Thomas, Kendall, Kendall, Kenefeck, Levisetti, Linterman, Mariño, Mohan, Mohan, Mohan, Nakayama, Noorchashm, Okada, Pape, Rasio, Reinhardt, Rojas, Roozendaal, Serreze, Silva, Takahashi, Ueno, Unanue, Victora, Victora, Vinuesa, Vomund, Williams, Xiaoxiao Wan, Yang, Zhang, Zhang, Zikherman, Zotos   +59 more
core   +2 more sources

Glucemia, insulinemia y secreción de insulina en ratas prepúberes hiperandrogenizadas e hiperestrogenizadas Glycemia, insulinemia and insulin secretion in prepubescent rats receiving high doses of androgens and strogens

Revista Cubana de Endocrinología, 2001
Se estudió el efecto de una sobredosis de enantato de testosterona y de benzoato de estradiol en ratas machos prepúberes, sobre el comportamiento de la glucemia y la insulinemia in vivo, durante una prueba de tolerancia a la glucosa.
Aimée Álvarez Álvarez, Eulises Díaz Díaz, Elisa María Castells Martínez, Beatríz Huguéz Hernandorena, Roberto M. González Suárez   +4 more
doaj