Results 71 to 80 of about 167,453,715 (202)

In Vivo Imaging of Transplanted Pancreatic Islets

open access: yesFrontiers in Endocrinology, 2018
The beta-cells in the islets of Langerhans in the pancreas secrete insulin and play an important role in glucose homeostasis. Diabetes, characterized by hyperglycemia, results from an absolute or a relative deficiency of the pancreatic beta-cell mass ...
Donghee Kim   +3 more
doaj   +1 more source

A Stepwise Method to Derive Functional Pancreatic Islet‐like Clusters from Human Pluripotent Stem Cells

open access: yesCurrent Protocols, Volume 6, Issue 9, September 2026.
Abstract The most common treatment for people with people with type 1 diabetes (T1D) requires injections of exogenous insulin to regulate blood glucose homeostasis. A longer‐term therapeutic solution for T1D has emerged whereby patients may regain insulin independence through transplantation of donated human pancreatic islets, which contain insulin ...
Manuj Bandral   +2 more
wiley   +1 more source

Advancing Type 1 Diabetes Treatment: 3 PM‐Oriented Innovations in Islet Transplantation and Biomaterial Engineering

open access: yesDiabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani   +4 more
wiley   +1 more source

Studi Mikroanatomi Pankreas Kodok Lembu Menggunakan Metode Pewarnaan Baku dan Immunohistokimia (MICROSCOPICAL STUDY OF PANCREAS OF BULLFROG USING CONVENTIONAL AND IMMUNOSTAINING METHODS)

open access: yesJurnal Veteriner, 2012
Morphology, distribution and relative frequency of endocrine cells in the pancreas Bullfrog (Ranacatesbeiana) were studied using conventional and immunohistochemical methods.
I Ketut Mudite Adnyane   +3 more
doaj  

Potential Involvement of Redox and Inflammatory Signalling in the Antihyperglycemic and Antioxidant Effects of Harmaline in Male Mice With Type 2 Diabetes

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
HAR may improve T2DM by enhancing antioxidant defences through Nrf2 activation while suppressing inflammation and RAS activity, supporting its capability to treat diabetes. ABSTRACT Introduction Type 2 diabetes mellitus (T2DM) is strongly associated with oxidative stress and inflammation.
Farima Malekinia   +5 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

open access: yesiNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little   +12 more
wiley   +1 more source

Conformational determinants of glucagon stability and aggregation kinetics in aqueous and commercial formulations

open access: yesProtein Science, Volume 35, Issue 9, September 2026.
Abstract Glucagon is a well‐established therapeutic peptide, widely used to treat hypoglycemia. Like many peptide drugs, it offers advantages such as specificity, biocompatibility, and high affinity for receptor targets, but suffers from limited physical and chemical stability.
Angelo Santoro   +4 more
wiley   +1 more source

VARIATION IN THE AREA OF ISLETS OF LANGERHANS IN SODIUM CYCLAMATE TREATED RATS

open access: yesPakistan Armed Forces Medical Journal, 2015
Objective: To observe the effects of sodium cyclamate on islets of langerhans in rats pancreas. Study Design: Laboratory based randomized control trial. Duration of study:  Anatomy Department, Army Medical College Rawalpindi, in collaboration with
Hina Kundi   +2 more
doaj   +2 more sources

The Endothelial Cells in Islets of Langerhans [PDF]

open access: yesUpsala Journal of Medical Sciences, 2005
The blood vessels of the pancreatic islets are of crucial importance for oxygen and metabolite supply, and dispersal of secreted hormones. In addition to this, endothelial cells have an important role in the revascularization process after islet transplantation.
openaire   +2 more sources

Antidiabetic effect of honey feeding in noise induced hyperglycemic rat: involvement of oxidative stress [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2015
Objective(s):In this study the effect of oral administration of honey on serum glucose, lipids, stress oxidative markers, and morphology of langerhans islets in noise induced hyperglycemic rats was investigated.
Saiedeh Arabmoazzen   +3 more
doaj  

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