Results 51 to 60 of about 167,453,715 (202)

Intravenous Oxytocin Does Not Affect Glucose‐Regulating Hormones or Markers of Bone Turnover During Graded Glucose Infusion in Healthy Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Oxytocin has been proposed to exert glucose‐stabilising effects via modulation of pancreatic hormone secretion and to play a role in bone homeostasis. However, human data under controlled conditions are limited. We investigated the effects of intravenously infused oxytocin during a graded glucose infusion on glucose‐regulating hormones and
Vivian Kliim‐Hansen, Ida M. Gether, Aliya M. Thomas, Anne‐Marie Ellegaard, Miriam G. Pedersen, Jens J. Holst, Bolette Hartmann, Filip K. Knop, Lærke S. Gasbjerg, Asger B. Lund   +9 more
wiley   +1 more source

Langerhans Islets: cell composition and the importance of pancreatic hormones for the body [PDF]

, 2022
Introducere. Insulele Langerhans reprezintă grupuri concentrice de celule endocrine care sunt dispersate în parenchimul pancreasului. Componenta endocrină a pancreasului are un rol primordial în reglarea proceselor metabolice, de aceea în ultimii ani tot
Calașnicov, Mădălina
core   +1 more source

The types of endocrine cells in the pancreas of Sunda porcupine (Hystrix javanica) [PDF]

Veterinary World, 2016
Aim: To identify the types of endocrine cells in the pancreas of the Sunda porcupine (Hystrix javanica) and its immunolocalization. Materials and Methods: Five adult H. javanica were used without sexual distinction.
Teguh Budipitojo, Yuda Heru Fibrianto, Guntari Titik Mulyani   +2 more
doaj   +1 more source

A DPP6‐Targeted PET Tracer for Non‐Invasive Imaging of Transplanted Human Islets

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Dipeptidyl peptidase‐like protein 6 (DPP6) is a potential molecular imaging biomarker for pancreatic and transplanted islets of Langerhans. 4hD29 is a single‐domain antibody with nanomolar affinity for DPP6. Here, we demonstrate the generation and validation of [68Ga]Ga‐NOTA‐4hD29 for Positron Emission Tomography (PET) imaging of ...
Amina Khalil, Arturo Roca‐Rivada, Svitlana Vasylovska, Lorenzo J. I. Balestri, Irina Velikyan, Sayro Jawurek, Alexandra C. Title, Burcak Yesildag, Luke R. Odell, Joey Lau, Decio L. Eizirik, Olof Eriksson   +11 more
wiley   +1 more source

Nephroprotective Effects of the Dual GCGR/GLP‐1R Agonist Survodutide in Hypertension‐Accelerated Diabetic Kidney Disease

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Survodutide is a novel long‐acting dual glucagon (GCGR)/glucagon‐like peptide‐1 (GLP‐1R) receptor agonist currently in phase‐3 clinical development for the treatment of people living with obesity and metabolic dysfunction‐associated steatohepatitis.
Alexander Hamilton, Louise Thisted, Maria Ougaard, Max Hahn, Kasper Andersen, Johanna Perens, Robert Augustin, Besnik Bajrami, Wolfgang Rist, Michael Christensen, Henrik H. Hansen, Thomas Klein   +11 more
wiley   +1 more source

Expression of vitamin D receptor, CYP24A1, and CYP27B1 in normal and inflamed canine pancreases

Frontiers in Veterinary Science, 2023
Vitamin D plays a role in anti-inflammatory processes, and the alteration of its metabolism is associated with the inflammatory processes of pancreatitis.
Dohee Lee, Sanggu Kim, Yoonhoi Koo, Yeon Chae, Juwon Wang, Soochong Kim, Taesik Yun, Mhan-Pyo Yang, Byeong-Teck Kang, Hakhyun Kim   +9 more
doaj   +1 more source

A holistic approach to type 1 diabetes: From advances in science and technology to equity in diabetes care

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Over the past century, the discovery of insulin transformed type 1 diabetes from a fatal disease into a manageable chronic condition, and the subsequent recognition of its autoimmune basis laid the foundation for screening and intervention before clinical onset.
Noriko Kodani
wiley   +1 more source

Moderate Intensity of Physical Exercise increased Β (Beta) Cell and Size of Langerhans Islets in Streptozotocin Induced Diabetes Mellitus Rats

Surabaya Physical Medicine and Rehabilitation Journal, 2019
Background: The death of β cells Langerhans islets in Diabetes Mellitus (DM) can cause loss of Langerhans islet function and worsen the progression of DM. Physical exercise plays a major part in DM treatment.
Sarah M Nurdin, Sri Mardjiati Mei Wulan, Nuniek Nugraheni   +2 more
doaj  

The Effects Of Simvastatin On Islets Of Langerhans In The Pancreas Of Rats: A Histological And Biochemical Study

Journal of Rawalpindi Medical College
Objective: This study explored the effect of simvastatin on the histomorphology of islets of Langerhans, glucose and insulin levels in rats. Study Design: The study was a one-year laboratory-based experimental control trial.
Abdullah Qamar, Hammad Gul Khan, Hina Kundi, Ayesha Ali, Sumyyia Bashir, Tooba Khurshid   +5 more
doaj   +1 more source

Metabolic Stress Shifts the Function of KCa3.1 Channels in Pancreatic Beta Cells From a Regulator of Membrane Potential to a Proapoptotic Factor

Archiv der Pharmazie, Volume 359, Issue 10, October 2026.
KATP and KCa3.1 channels are the main components of the regulatory K+ current “Kslow” of pancreatic beta cells. In a diabetogenic environment, the KCa3.1 component of Kslow decreases, and the channel is dysregulated. A targeted pharmacological approach reveals that KCa3.1 channels are functional in mitochondria.
Jurek Hense, Lena Beuke, Christina Kick, Bernhard Wünsch, Martina Düfer   +4 more
wiley   +1 more source